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TAp73 depletion accelerates aging through metabolic dysregulation.

Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, Marino A, Federici M, Dinsdale D, Knight RA, Melino G, Mak TW.

Genes Dev. 2012 Sep 15;26(18):2009-14. doi: 10.1101/gad.197640.112.


The p53 family grows old.

Flores ER, Lozano G.

Genes Dev. 2012 Sep 15;26(18):1997-2000. doi: 10.1101/gad.202648.112.


Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats.

Ungvari Z, Labinskyy N, Gupte S, Chander PN, Edwards JG, Csiszar A.

Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2121-8. doi: 10.1152/ajpheart.00012.2008. Epub 2008 Mar 7.


p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation.

Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Ariyoshi M, Mita Y, Ikeda K, Okigaki M, Adachi S, Tanaka H, Takamatsu T, Matsubara H.

Circ Heart Fail. 2012 Jan;5(1):106-15. doi: 10.1161/CIRCHEARTFAILURE.111.961565. Epub 2011 Nov 9. Erratum in: Circ Heart Fail. 2014 Mar 1;7(2):383.


Metabolic pathways regulated by TAp73 in response to oxidative stress.

Agostini M, Annicchiarico-Petruzzelli M, Melino G, Rufini A.

Oncotarget. 2016 May 24;7(21):29881-900. doi: 10.18632/oncotarget.8935.


L-Lactate Protects Skin Fibroblasts against Aging-Associated Mitochondrial Dysfunction via Mitohormesis.

Zelenka J, Dvořák A, Alán L.

Oxid Med Cell Longev. 2015;2015:351698. doi: 10.1155/2015/351698. Epub 2015 Jun 10.


Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence.

Yao J, Hamilton RT, Cadenas E, Brinton RD.

Biochim Biophys Acta. 2010 Oct;1800(10):1121-6. doi: 10.1016/j.bbagen.2010.06.002. Epub 2010 Jun 9.


Comprehensive Mitochondrial Metabolic Shift during the Critical Node of Seed Ageing in Rice.

Yin G, Whelan J, Wu S, Zhou J, Chen B, Chen X, Zhang J, He J, Xin X, Lu X.

PLoS One. 2016 Apr 28;11(4):e0148013. doi: 10.1371/journal.pone.0148013. eCollection 2016.


Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture.

Rivera-Torres J, Acín-Perez R, Cabezas-Sánchez P, Osorio FG, Gonzalez-Gómez C, Megias D, Cámara C, López-Otín C, Enríquez JA, Luque-García JL, Andrés V.

J Proteomics. 2013 Oct 8;91:466-77. doi: 10.1016/j.jprot.2013.08.008. Epub 2013 Aug 20.


RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant Defense.

Ren C, Zhang J, Yan W, Zhang Y, Chen X.

J Biol Chem. 2016 Apr 29;291(18):9629-37. doi: 10.1074/jbc.M115.712125. Epub 2016 Feb 23.


Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation.

Kalfalah F, Sobek S, Bornholz B, Götz-Rösch C, Tigges J, Fritsche E, Krutmann J, Köhrer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F.

Exp Gerontol. 2014 Aug;56:59-68. doi: 10.1016/j.exger.2014.03.017. Epub 2014 Mar 31.


Upregulation of cytochrome c oxidase subunit 6b1 (Cox6b1) and formation of mitochondrial supercomplexes: implication of Cox6b1 in the effect of calorie restriction.

Kim SE, Mori R, Komatsu T, Chiba T, Hayashi H, Park S, Sugawa MD, Dencher NA, Shimokawa I.

Age (Dordr). 2015 Jun;37(3):9787. doi: 10.1007/s11357-015-9787-8. Epub 2015 May 1.


Decreased Integrity, Content, and Increased Transcript Level of Mitochondrial DNA Are Associated with Keratoconus.

Hao XD, Chen ZL, Qu ML, Zhao XW, Li SX, Chen P.

PLoS One. 2016 Oct 26;11(10):e0165580. doi: 10.1371/journal.pone.0165580. eCollection 2016.


Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F0-ATP synthase.

Bergeaud M, Mathieu L, Guillaume A, Moll UM, Mignotte B, Le Floch N, Vayssière JL, Rincheval V.

Cell Cycle. 2013 Sep 1;12(17):2781-93. doi: 10.4161/cc.25870. Epub 2013 Aug 6.


Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis.

Lebedeva MA, Eaton JS, Shadel GS.

Biochim Biophys Acta. 2009 May;1787(5):328-34. doi: 10.1016/j.bbabio.2009.01.004. Epub 2009 Jan 20.


Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function.

Wei YH, Lu CY, Lee HC, Pang CY, Ma YS.

Ann N Y Acad Sci. 1998 Nov 20;854:155-70. Review.


Loss of cytochrome c oxidase promotes RAS-dependent ROS production from the ER resident NADPH oxidase, Yno1p, in yeast.

Leadsham JE, Sanders G, Giannaki S, Bastow EL, Hutton R, Naeimi WR, Breitenbach M, Gourlay CW.

Cell Metab. 2013 Aug 6;18(2):279-86. doi: 10.1016/j.cmet.2013.07.005.


Effect of thyroid hormone on mitochondrial properties and oxidative stress in cells from patients with mtDNA defects.

Menzies KJ, Robinson BH, Hood DA.

Am J Physiol Cell Physiol. 2009 Feb;296(2):C355-62. doi: 10.1152/ajpcell.00415.2007. Epub 2008 Nov 26.

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