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Items: 1 to 20 of 113

1.

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury.

Monshi MM, Faulkner L, Gibson A, Jenkins RE, Farrell J, Earnshaw CJ, Alfirevic A, Cederbrant K, Daly AK, French N, Pirmohamed M, Park BK, Naisbitt DJ.

Hepatology. 2013 Feb;57(2):727-39. doi: 10.1002/hep.26077.

PMID:
22987284
2.

Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury.

Kim SH, Saide K, Farrell J, Faulkner L, Tailor A, Ogese M, Daly AK, Pirmohamed M, Park BK, Naisbitt DJ.

Hepatology. 2015 Sep;62(3):887-99. doi: 10.1002/hep.27912. Epub 2015 Jul 23.

PMID:
25998949
3.

T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms.

Bell CC, Faulkner L, Martinsson K, Farrell J, Alfirevic A, Tugwood J, Pirmohamed M, Naisbitt DJ, Park BK.

Chem Res Toxicol. 2013 May 20;26(5):759-66. doi: 10.1021/tx400060p. Epub 2013 Apr 12.

PMID:
23541086
4.

HLA haplotype determines hapten or p-i T cell reactivity to flucloxacillin.

Wuillemin N, Adam J, Fontana S, Krähenbühl S, Pichler WJ, Yerly D.

J Immunol. 2013 May 15;190(10):4956-64. doi: 10.4049/jimmunol.1202949. Epub 2013 Apr 17.

5.

T cells infiltrate the liver and kill hepatocytes in HLA-B(∗)57:01-associated floxacillin-induced liver injury.

Wuillemin N, Terracciano L, Beltraminelli H, Schlapbach C, Fontana S, Krähenbühl S, Pichler WJ, Yerly D.

Am J Pathol. 2014 Jun;184(6):1677-82. doi: 10.1016/j.ajpath.2014.02.018. Epub 2014 Apr 13.

PMID:
24731753
6.

Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model.

Nattrass R, Faulkner L, Vocanson M, Antoine DJ, Kipar A, Kenna G, Nicolas JF, Park BK, Naisbitt DJ.

Toxicol Sci. 2015 Jul;146(1):146-56. doi: 10.1093/toxsci/kfv077. Epub 2015 Apr 14.

PMID:
25877613
7.

The safety of flucloxacillin in HIV-infected patients with positive HLA-B*5701 genotype.

Vera JH, Naous N, Mackie N, Winston A, Cooke G.

AIDS. 2013 Jan 28;27(3):484-5. doi: 10.1097/QAD.0b013e32835a9a0d.

PMID:
23032409
8.

Negative regulation by PD-L1 during drug-specific priming of IL-22-secreting T cells and the influence of PD-1 on effector T cell function.

Gibson A, Ogese M, Sullivan A, Wang E, Saide K, Whitaker P, Peckham D, Faulkner L, Park BK, Naisbitt DJ.

J Immunol. 2014 Mar 15;192(6):2611-2621. doi: 10.4049/jimmunol.1302720. Epub 2014 Feb 7.

9.

Promiscuous T-cell responses to drugs and drug-haptens.

Yaseen FS, Saide K, Kim SH, Monshi M, Tailor A, Wood S, Meng X, Jenkins R, Faulkner L, Daly AK, Pirmohamed M, Park BK, Naisbitt DJ.

J Allergy Clin Immunol. 2015 Aug;136(2):474-6.e8. doi: 10.1016/j.jaci.2015.02.036. Epub 2015 Apr 22. No abstract available.

PMID:
25910715
10.

T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reaction.

Schnyder B, Frutig K, Mauri-Hellweg D, Limat A, Yawalkar N, Pichler WJ.

Clin Exp Allergy. 1998 Nov;28(11):1412-7.

PMID:
9824415
11.

Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity.

Wu Y, Farrell J, Pirmohamed M, Park BK, Naisbitt DJ.

J Allergy Clin Immunol. 2007 Apr;119(4):973-81. Epub 2007 Feb 22.

PMID:
17320939
12.

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.

Daly AK, Donaldson PT, Bhatnagar P, Shen Y, Pe'er I, Floratos A, Daly MJ, Goldstein DB, John S, Nelson MR, Graham J, Park BK, Dillon JF, Bernal W, Cordell HJ, Pirmohamed M, Aithal GP, Day CP; DILIGEN Study; International SAE Consortium.

Nat Genet. 2009 Jul;41(7):816-9. doi: 10.1038/ng.379. Epub 2009 May 31.

PMID:
19483685
14.

Characterization of the antigen specificity of T-cell clones from piperacillin-hypersensitive patients with cystic fibrosis.

El-Ghaiesh S, Monshi MM, Whitaker P, Jenkins R, Meng X, Farrell J, Elsheikh A, Peckham D, French N, Pirmohamed M, Park BK, Naisbitt DJ.

J Pharmacol Exp Ther. 2012 Jun;341(3):597-610. doi: 10.1124/jpet.111.190900. Epub 2012 Feb 27.

15.

HLA-B*5701 and flucloxacillin associated drug-induced liver disease.

Phillips EJ, Mallal SA.

AIDS. 2013 Jan 28;27(3):491-2. doi: 10.1097/QAD.0b013e32835ca9d5. No abstract available.

PMID:
23291545
17.

Abacavir induced T cell reactivity from drug naïve individuals shares features of allo-immune responses.

Adam J, Wuillemin N, Watkins S, Jamin H, Eriksson KK, Villiger P, Fontana S, Pichler WJ, Yerly D.

PLoS One. 2014 Apr 21;9(4):e95339. doi: 10.1371/journal.pone.0095339. eCollection 2014.

18.

Human leukocyte antigen and idiosyncratic adverse drug reactions.

Usui T, Naisbitt DJ.

Drug Metab Pharmacokinet. 2017 Feb;32(1):21-30. doi: 10.1016/j.dmpk.2016.11.003. Epub 2016 Nov 18. Review.

PMID:
28017537
19.

Characterization of T lymphocyte clones derived from Porphyromonas gingivalis infected subjects.

Gemmell E, Woodford V, Seymour GJ.

J Periodontal Res. 1996 Jan;31(1):47-56.

PMID:
8636876
20.

Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine.

Mauri-Hellweg D, Bettens F, Mauri D, Brander C, Hunziker T, Pichler WJ.

J Immunol. 1995 Jul 1;155(1):462-72.

PMID:
7602118

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