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Items: 1 to 20 of 118


Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans.

Adelman K, Lis JT.

Nat Rev Genet. 2012 Oct;13(10):720-31. doi: 10.1038/nrg3293. Review.


Promoter proximal pausing on genes in metazoans.

Gilmour DS.

Chromosoma. 2009 Feb;118(1):1-10. doi: 10.1007/s00412-008-0182-4. Epub 2008 Oct 2. Review.


Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide.

Chen F, Gao X, Shilatifard A.

Genes Dev. 2015 Jan 1;29(1):39-47. doi: 10.1101/gad.246173.114.


PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II.

Chen FX, Woodfin AR, Gardini A, Rickels RA, Marshall SA, Smith ER, Shiekhattar R, Shilatifard A.

Cell. 2015 Aug 27;162(5):1003-15. doi: 10.1016/j.cell.2015.07.042. Epub 2015 Aug 13.


Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex.

Missra A, Gilmour DS.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11301-6. doi: 10.1073/pnas.1000681107. Epub 2010 Jun 4.


Promoter-proximal Pol II: when stalling speeds things up.

Nechaev S, Adelman K.

Cell Cycle. 2008 Jun 1;7(11):1539-44. Epub 2008 Mar 27. Review.


Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways.

Liu X, Kraus WL, Bai X.

Trends Biochem Sci. 2015 Sep;40(9):516-25. doi: 10.1016/j.tibs.2015.07.003. Epub 2015 Aug 4. Review.


SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation.

Kapoor-Vazirani P, Kagey JD, Vertino PM.

Mol Cell Biol. 2011 Apr;31(8):1594-609. doi: 10.1128/MCB.00524-10. Epub 2011 Feb 14.


Regulation of c-myc and immunoglobulin kappa gene transcription by promoter-proximal pausing of RNA polymerase II.

Schneider EE, Albert T, Wolf DA, Eick D.

Curr Top Microbiol Immunol. 1999;246:225-31. Review.


Kinetics of promoter Pol II on Hsp70 reveal stable pausing and key insights into its regulation.

Buckley MS, Kwak H, Zipfel WR, Lis JT.

Genes Dev. 2014 Jan 1;28(1):14-9. doi: 10.1101/gad.231886.113.


Distinct mechanisms of transcriptional pausing orchestrated by GAGA factor and M1BP, a novel transcription factor.

Li J, Gilmour DS.

EMBO J. 2013 Jul 3;32(13):1829-41. doi: 10.1038/emboj.2013.111. Epub 2013 May 24.


RNA polymerase II pausing during development.

Gaertner B, Zeitlinger J.

Development. 2014 Mar;141(6):1179-83. doi: 10.1242/dev.088492. Review.


Coupling polymerase pausing and chromatin landscapes for precise regulation of transcription.

Gilchrist DA, Adelman K.

Biochim Biophys Acta. 2012 Jul;1819(7):700-6. doi: 10.1016/j.bbagrm.2012.02.015. Epub 2012 Mar 2. Review.


Stable pausing by RNA polymerase II provides an opportunity to target and integrate regulatory signals.

Henriques T, Gilchrist DA, Nechaev S, Bern M, Muse GW, Burkholder A, Fargo DC, Adelman K.

Mol Cell. 2013 Nov 21;52(4):517-28. doi: 10.1016/j.molcel.2013.10.001. Epub 2013 Oct 31.


NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila.

Lee C, Li X, Hechmer A, Eisen M, Biggin MD, Venters BJ, Jiang C, Li J, Pugh BF, Gilmour DS.

Mol Cell Biol. 2008 May;28(10):3290-300. doi: 10.1128/MCB.02224-07. Epub 2008 Mar 10.


Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation.

Nechaev S, Adelman K.

Biochim Biophys Acta. 2011 Jan;1809(1):34-45. doi: 10.1016/j.bbagrm.2010.11.001. Epub 2010 Nov 13. Review.


Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networks.

Gilchrist DA, Fromm G, dos Santos G, Pham LN, McDaniel IE, Burkholder A, Fargo DC, Adelman K.

Genes Dev. 2012 May 1;26(9):933-44. doi: 10.1101/gad.187781.112.

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