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Items: 1 to 20 of 131

1.

A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2.

Lucas-Hourani M, Lupan A, Desprès P, Thoret S, Pamlard O, Dubois J, Guillou C, Tangy F, Vidalain PO, Munier-Lehmann H.

J Biomol Screen. 2013 Feb;18(2):172-9. doi: 10.1177/1087057112460091. Epub 2012 Sep 14.

PMID:
22983165
2.

Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays.

Pohjala L, Utt A, Varjak M, Lulla A, Merits A, Ahola T, Tammela P.

PLoS One. 2011;6(12):e28923. doi: 10.1371/journal.pone.0028923. Epub 2011 Dec 19.

3.

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling.

Fros JJ, Liu WJ, Prow NA, Geertsema C, Ligtenberg M, Vanlandingham DL, Schnettler E, Vlak JM, Suhrbier A, Khromykh AA, Pijlman GP.

J Virol. 2010 Oct;84(20):10877-87. doi: 10.1128/JVI.00949-10. Epub 2010 Aug 4.

4.

Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection.

Ashbrook AW, Lentscher AJ, Zamora PF, Silva LA, May NA, Bauer JA, Morrison TE, Dermody TS.

MBio. 2016 May 24;7(3). pii: e00693-16. doi: 10.1128/mBio.00693-16.

5.

Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus.

Bassetto M, De Burghgraeve T, Delang L, Massarotti A, Coluccia A, Zonta N, Gatti V, Colombano G, Sorba G, Silvestri R, Tron GC, Neyts J, Leyssen P, Brancale A.

Antiviral Res. 2013 Apr;98(1):12-8. doi: 10.1016/j.antiviral.2013.01.002. Epub 2013 Feb 1.

PMID:
23380636
6.

Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection.

Das I, Basantray I, Mamidi P, Nayak TK, B M P, Chattopadhyay S, Chattopadhyay S.

PLoS One. 2014 Jun 24;9(6):e100531. doi: 10.1371/journal.pone.0100531. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0122906.

7.

Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression.

Kaur P, Thiruchelvan M, Lee RC, Chen H, Chen KC, Ng ML, Chu JJ.

Antimicrob Agents Chemother. 2013 Jan;57(1):155-67. doi: 10.1128/AAC.01467-12. Epub 2012 Oct 22.

8.

Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component.

Bouraï M, Lucas-Hourani M, Gad HH, Drosten C, Jacob Y, Tafforeau L, Cassonnet P, Jones LM, Judith D, Couderc T, Lecuit M, André P, Kümmerer BM, Lotteau V, Desprès P, Tangy F, Vidalain PO.

J Virol. 2012 Mar;86(6):3121-34. doi: 10.1128/JVI.06390-11. Epub 2012 Jan 18.

9.

Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2.

Utt A, Das PK, Varjak M, Lulla V, Lulla A, Merits A.

J Virol. 2015 Mar;89(6):3145-62. doi: 10.1128/JVI.03213-14. Epub 2014 Dec 31. Erratum in: J Virol. 2016 Sep 1;90(17):8030.

10.

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.

Delang L, Segura Guerrero N, Tas A, Quérat G, Pastorino B, Froeyen M, Dallmeier K, Jochmans D, Herdewijn P, Bello F, Snijder EJ, de Lamballerie X, Martina B, Neyts J, van Hemert MJ, Leyssen P.

J Antimicrob Chemother. 2014 Oct;69(10):2770-84. doi: 10.1093/jac/dku209. Epub 2014 Jun 20.

PMID:
24951535
11.

Discovery of a novel antiviral agent targeting the nonstructural protein 4 (nsP4) of chikungunya virus.

Wada Y, Orba Y, Sasaki M, Kobayashi S, Carr MJ, Nobori H, Sato A, Hall WW, Sawa H.

Virology. 2017 May;505:102-112. doi: 10.1016/j.virol.2017.02.014. Epub 2017 Feb 23.

PMID:
28236746
12.

Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication.

Di Mola A, Peduto A, La Gatta A, Delang L, Pastorino B, Neyts J, Leyssen P, de Rosa M, Filosa R.

Bioorg Med Chem. 2014 Nov 1;22(21):6014-25. doi: 10.1016/j.bmc.2014.09.013. Epub 2014 Sep 16.

PMID:
25282648
13.

Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication.

Scholte FE, Tas A, Albulescu IC, Žusinaite E, Merits A, Snijder EJ, van Hemert MJ.

J Virol. 2015 Apr;89(8):4457-69. doi: 10.1128/JVI.03612-14. Epub 2015 Feb 4.

14.

Development of a Real-Time Cell Analysing (RTCA) method as a fast and accurate screen for the selection of chikungunya virus replication inhibitors.

Marlina S, Shu MH, AbuBakar S, Zandi K.

Parasit Vectors. 2015 Nov 9;8:579. doi: 10.1186/s13071-015-1104-y.

15.

The green tea catechin, epigallocatechin gallate inhibits chikungunya virus infection.

Weber C, Sliva K, von Rhein C, Kümmerer BM, Schnierle BS.

Antiviral Res. 2015 Jan;113:1-3. doi: 10.1016/j.antiviral.2014.11.001. Epub 2014 Nov 11.

PMID:
25446334
16.

High throughput proteomic analysis and a comparative review identify the nuclear chaperone, Nucleophosmin among the common set of proteins modulated in Chikungunya virus infection.

Abraham R, Mudaliar P, Jaleel A, Srikanth J, Sreekumar E.

J Proteomics. 2015 Apr 29;120:126-41. doi: 10.1016/j.jprot.2015.03.007. Epub 2015 Mar 14. Review.

PMID:
25782748
17.

Identification of chikungunya virus nsP2 protease inhibitors using structure-base approaches.

Nguyen PT, Yu H, Keller PA.

J Mol Graph Model. 2015 Apr;57:1-8. doi: 10.1016/j.jmgm.2015.01.001. Epub 2015 Jan 12.

PMID:
25622129
18.

Antiviral activity of silymarin against chikungunya virus.

Lani R, Hassandarvish P, Chiam CW, Moghaddam E, Chu JJ, Rausalu K, Merits A, Higgs S, Vanlandingham D, Abu Bakar S, Zandi K.

Sci Rep. 2015 Jun 16;5:11421. doi: 10.1038/srep11421.

19.

Development and characterization of monoclonal antibody against non-structural protein-2 of Chikungunya virus and its application.

Chattopadhyay S, Kumar A, Mamidi P, Nayak TK, Das I, Chhatai J, Basantray I, Bramha U, Maiti PK, Singh S, Suryawanshi AR, Chattopadhyay S.

J Virol Methods. 2014 Apr;199:86-94. doi: 10.1016/j.jviromet.2014.01.008. Epub 2014 Jan 21.

PMID:
24462973
20.

Chikungunya virus: an update on antiviral development and challenges.

Kaur P, Chu JJ.

Drug Discov Today. 2013 Oct;18(19-20):969-83. doi: 10.1016/j.drudis.2013.05.002. Epub 2013 May 15. Review.

PMID:
23684571

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