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A relatively low level of ribosome depurination by mutant forms of ricin toxin A chain can trigger protein synthesis inhibition, cell signaling and apoptosis in mammalian cells.

Jetzt AE, Cheng JS, Li XP, Tumer NE, Cohick WS.

Int J Biochem Cell Biol. 2012 Dec;44(12):2204-11. doi: 10.1016/j.biocel.2012.09.004. Epub 2012 Sep 12.


Ricin A-chain requires c-Jun N-terminal kinase to induce apoptosis in nontransformed epithelial cells.

Jetzt AE, Cheng JS, Tumer NE, Cohick WS.

Int J Biochem Cell Biol. 2009 Dec;41(12):2503-10. doi: 10.1016/j.biocel.2009.08.007. Epub 2009 Aug 18.


Ribosome depurination is not sufficient for ricin-mediated cell death in Saccharomyces cerevisiae.

Li XP, Baricevic M, Saidasan H, Tumer NE.

Infect Immun. 2007 Jan;75(1):417-28. Epub 2006 Nov 13.


The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells.

May KL, Li XP, Martínez-Azorín F, Ballesta JP, Grela P, Tchórzewski M, Tumer NE.

FEBS J. 2012 Oct;279(20):3925-36. doi: 10.1111/j.1742-4658.2012.08752.x. Epub 2012 Sep 11.


Ricin inhibits activation of the unfolded protein response by preventing splicing of the HAC1 mRNA.

Parikh BA, Tortora A, Li XP, Tumer NE.

J Biol Chem. 2008 Mar 7;283(10):6145-53. doi: 10.1074/jbc.M707981200. Epub 2008 Jan 7.


Identification of small molecules that suppress ricin-induced stress-activated signaling pathways.

Wahome PG, Ahlawat S, Mantis NJ.

PLoS One. 2012;7(11):e49075. doi: 10.1371/journal.pone.0049075. Epub 2012 Nov 1.


Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome.

Jetzt AE, Li XP, Tumer NE, Cohick WS.

Toxicol Appl Pharmacol. 2016 Sep 15;310:120-128. doi: 10.1016/j.taap.2016.09.004. [Epub ahead of print]


Targeting ricin to the ribosome.

May KL, Yan Q, Tumer NE.

Toxicon. 2013 Jul;69:143-51. doi: 10.1016/j.toxicon.2013.02.001. Epub 2013 Feb 20. Review.


Wild type RTA and less toxic variants have distinct requirements for Png1 for their depurination activity and toxicity in Saccharomyces cerevisiae.

Yan Q, Li XP, Tumer NE.

PLoS One. 2014 Dec 1;9(12):e113719. doi: 10.1371/journal.pone.0113719. eCollection 2014.


Alteration of an amino acid residue outside the active site of the ricin A chain reduces its toxicity towards yeast ribosomes.

Gould JH, Hartley MR, Welsh PC, Hoshizaki DK, Frankel A, Roberts LM, Lord JM.

Mol Gen Genet. 1991 Nov;230(1-2):81-90.


Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk.

Li XP, Kahn PC, Kahn JN, Grela P, Tumer NE.

J Biol Chem. 2013 Oct 18;288(42):30270-84. doi: 10.1074/jbc.M113.510966. Epub 2013 Sep 3.


Ribosome inactivation by ricin A chain: a sensitive method to assess the activity of wild-type and mutant polypeptides.

May MJ, Hartley MR, Roberts LM, Krieg PA, Osborn RW, Lord JM.

EMBO J. 1989 Jan;8(1):301-8.


Ribosome inactivating protein saporin induces apoptosis through mitochondrial cascade, independent of translation inhibition.

Sikriwal D, Ghosh P, Batra JK.

Int J Biochem Cell Biol. 2008;40(12):2880-8. doi: 10.1016/j.biocel.2008.06.004. Epub 2008 Jun 20.


Adapting yeast as model to study ricin toxin a uptake and trafficking.

Becker B, Schmitt MJ.

Toxins (Basel). 2011 Jul;3(7):834-47. doi: 10.3390/toxins3070834. Epub 2011 Jul 5.


The ribosomal stalk is required for ribosome binding, depurination of the rRNA and cytotoxicity of ricin A chain in Saccharomyces cerevisiae.

Chiou JC, Li XP, Remacha M, Ballesta JP, Tumer NE.

Mol Microbiol. 2008 Dec;70(6):1441-52. doi: 10.1111/j.1365-2958.2008.06492.x. Epub 2008 Oct 30.


Expression of pokeweed antiviral protein in mammalian cells activates c-Jun NH2-terminal kinase without causing apoptosis.

Chan Tung KW, Mansouri S, Hudak KA.

Int J Biochem Cell Biol. 2008;40(11):2452-61. doi: 10.1016/j.biocel.2008.04.021. Epub 2008 May 21.

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