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Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium.

Kirman CR, Hays SM, Aylward LL, Suh M, Harris MA, Thompson CM, Haws LC, Proctor DM.

Chem Biol Interact. 2012 Oct 25;200(1):45-64. doi: 10.1016/j.cbi.2012.08.016. Epub 2012 Sep 6. Erratum in: Chem Biol Interact. 2013 Aug 25;204(3):201-6.


Physiologically based pharmacokinetic model for humans orally exposed to chromium.

Kirman CR, Aylward LL, Suh M, Harris MA, Thompson CM, Haws LC, Proctor DM, Lin SS, Parker W, Hays SM.

Chem Biol Interact. 2013 Jun 25;204(1):13-27. doi: 10.1016/j.cbi.2013.04.003. Epub 2013 Apr 17.


Hexavalent chromium reduction kinetics in rodent stomach contents.

Proctor DM, Suh M, Aylward LL, Kirman CR, Harris MA, Thompson CM, Gürleyük H, Gerads R, Haws LC, Hays SM.

Chemosphere. 2012 Oct;89(5):487-93. doi: 10.1016/j.chemosphere.2012.04.065. Epub 2012 Jun 8.


Ingestion of chromium(VI) in drinking water by human volunteers: absorption, distribution, and excretion of single and repeated doses.

Kerger BD, Finley BL, Corbett GE, Dodge DG, Paustenbach DJ.

J Toxicol Environ Health. 1997 Jan;50(1):67-95.


Human health risk and exposure assessment of chromium (VI) in tap water.

Paustenbach DJ, Finley BL, Mowat FS, Kerger BD.

J Toxicol Environ Health A. 2003 Jul 25;66(14):1295-339.


A chronic oral reference dose for hexavalent chromium-induced intestinal cancer.

Thompson CM, Kirman CR, Proctor DM, Haws LC, Suh M, Hays SM, Hixon JG, Harris MA.

J Appl Toxicol. 2014 May;34(5):525-36. doi: 10.1002/jat.2907. Epub 2013 Aug 14.


A physiologically based model for the ingestion of chromium(III) and chromium(VI) by humans.

O'Flaherty EJ, Kerger BD, Hays SM, Paustenbach DJ.

Toxicol Sci. 2001 Apr;60(2):196-213.


Human ingestion of chromium (VI) in drinking water: pharmacokinetics following repeated exposure.

Finley BL, Kerger BD, Katona MW, Gargas ML, Corbett GC, Paustenbach DJ.

Toxicol Appl Pharmacol. 1997 Jan;142(1):151-9.


Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: implications for carcinogenic modes of action.

Thompson CM, Proctor DM, Suh M, Haws LC, Hébert CD, Mann JF, Shertzer HG, Hixon JG, Harris MA.

Toxicol Sci. 2012 Jan;125(1):79-90. doi: 10.1093/toxsci/kfr280. Epub 2011 Oct 19.


Mechanistic insights from the NTP studies of chromium.

Witt KL, Stout MD, Herbert RA, Travlos GS, Kissling GE, Collins BJ, Hooth MJ.

Toxicol Pathol. 2013 Feb;41(2):326-42. doi: 10.1177/0192623312469856. Epub 2013 Jan 18.


An evaluation of in vivo models for toxicokinetics of hexavalent chromium in the stomach.

Sasso AF, Schlosser PM.

Toxicol Appl Pharmacol. 2015 Sep 15;287(3):293-8. doi: 10.1016/j.taap.2015.06.016. Epub 2015 Jun 27.


Is hexavalent chromium carcinogenic via ingestion? A weight-of-evidence review.

Proctor DM, Otani JM, Finley BL, Paustenbach DJ, Bland JA, Speizer N, Sargent EV.

J Toxicol Environ Health A. 2002 May 24;65(10):701-46. Review.


Improved physiologically based pharmacokinetic model for oral exposures to chromium in mice, rats, and humans to address temporal variation and sensitive populations.

Kirman CR, Suh M, Proctor DM, Hays SM.

Toxicol Appl Pharmacol. 2017 Jun 15;325:9-17. doi: 10.1016/j.taap.2017.03.023. Epub 2017 Apr 5.


High concentrations of hexavalent chromium in drinking water alter iron homeostasis in F344 rats and B6C3F1 mice.

Suh M, Thompson CM, Kirman CR, Carakostas MC, Haws LC, Harris MA, Proctor DM.

Food Chem Toxicol. 2014 Mar;65:381-8. doi: 10.1016/j.fct.2014.01.009. Epub 2014 Jan 10.


Synchrotron-based imaging of chromium and γ-H2AX immunostaining in the duodenum following repeated exposure to Cr(VI) in drinking water.

Thompson CM, Seiter J, Chappell MA, Tappero RV, Proctor DM, Suh M, Wolf JC, Haws LC, Vitale R, Mittal L, Kirman CR, Hays SM, Harris MA.

Toxicol Sci. 2015 Jan;143(1):16-25. doi: 10.1093/toxsci/kfu206. Epub 2014 Oct 28.


A revised model of ex-vivo reduction of hexavalent chromium in human and rodent gastric juices.

Schlosser PM, Sasso AF.

Toxicol Appl Pharmacol. 2014 Oct 15;280(2):352-61. doi: 10.1016/j.taap.2014.08.010. Epub 2014 Aug 20.


Exposure to hexavalent chromium resulted in significantly higher tissue chromium burden compared with trivalent chromium following similar oral doses to male F344/N rats and female B6C3F1 mice.

Collins BJ, Stout MD, Levine KE, Kissling GE, Melnick RL, Fennell TR, Walden R, Abdo K, Pritchard JB, Fernando RA, Burka LT, Hooth MJ.

Toxicol Sci. 2010 Dec;118(2):368-79. doi: 10.1093/toxsci/kfq263. Epub 2010 Sep 15.


Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium.

Thompson CM, Proctor DM, Haws LC, Hébert CD, Grimes SD, Shertzer HG, Kopec AK, Hixon JG, Zacharewski TR, Harris MA.

Toxicol Sci. 2011 Sep;123(1):58-70. doi: 10.1093/toxsci/kfr164. Epub 2011 Jun 28.

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