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Items: 1 to 20 of 87

1.

TOPORS modulates H2AX discriminating genotoxic stresses.

Seong KM, Nam SY, Kim JY, Yang KH, An S, Jin YW, Kim CS.

J Biochem Mol Toxicol. 2012 Nov;26(11):429-38. doi: 10.1002/jbt.21438. Epub 2012 Sep 12.

PMID:
22972498
2.

Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo.

Weger S, Hammer E, Heilbronn R.

FEBS Lett. 2005 Sep 12;579(22):5007-12.

PMID:
16122737
3.

TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.

Pungaliya P, Kulkarni D, Park HJ, Marshall H, Zheng H, Lackland H, Saleem A, Rubin EH.

J Proteome Res. 2007 Oct;6(10):3918-23. Epub 2007 Sep 6.

PMID:
17803295
4.

The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies.

Rasheed ZA, Saleem A, Ravee Y, Pandolfi PP, Rubin EH.

Exp Cell Res. 2002 Jul 15;277(2):152-60.

PMID:
12083797
5.

Monoubiquitination of H2AX protein regulates DNA damage response signaling.

Pan MR, Peng G, Hung WC, Lin SY.

J Biol Chem. 2011 Aug 12;286(32):28599-607. doi: 10.1074/jbc.M111.256297. Epub 2011 Jun 15.

PMID:
21676867
6.

Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation.

Neumayer G, Helfricht A, Shim SY, Le HT, Lundin C, Belzil C, Chansard M, Yu Y, Lees-Miller SP, Gruss OJ, van Attikum H, Helleday T, Nguyen MD.

J Biol Chem. 2012 Dec 7;287(50):42206-22. doi: 10.1074/jbc.M112.385674. Epub 2012 Oct 8.

PMID:
23045526
7.

Identification of phosphorylation sites of TOPORS and a role for serine 98 in the regulation of ubiquitin but not SUMO E3 ligase activity.

Park HJ, Zheng H, Kulkarni D, Kerrigan J, Pungaliya P, Saleem A, Rubin EH.

Biochemistry. 2008 Dec 30;47(52):13887-96. doi: 10.1021/bi801904q.

PMID:
19053840
8.

topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage.

Lin L, Ozaki T, Takada Y, Kageyama H, Nakamura Y, Hata A, Zhang JH, Simonds WF, Nakagawara A, Koseki H.

Oncogene. 2005 May 12;24(21):3385-96.

PMID:
15735665
9.

Targeting BRG1 chromatin remodeler via its bromodomain for enhanced tumor cell radiosensitivity in vitro and in vivo.

Kwon SJ, Lee SK, Na J, Lee SA, Lee HS, Park JH, Chung JK, Youn H, Kwon J.

Mol Cancer Ther. 2015 Feb;14(2):597-607. doi: 10.1158/1535-7163.MCT-14-0372. Epub 2014 Dec 12.

PMID:
25504753
10.

Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.

Rao VA, Fan AM, Meng L, Doe CF, North PS, Hickson ID, Pommier Y.

Mol Cell Biol. 2005 Oct;25(20):8925-37.

PMID:
16199871
11.

The E3 ligase Topors induces the accumulation of polysumoylated forms of DNA topoisomerase I in vitro and in vivo.

Hammer E, Heilbronn R, Weger S.

FEBS Lett. 2007 Nov 27;581(28):5418-24. Epub 2007 Oct 30.

PMID:
17976381
12.

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

Rajendra R, Malegaonkar D, Pungaliya P, Marshall H, Rasheed Z, Brownell J, Liu LF, Lutzker S, Saleem A, Rubin EH.

J Biol Chem. 2004 Aug 27;279(35):36440-4. Epub 2004 Jul 9.

PMID:
15247280
13.

Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1.

Guan B, Pungaliya P, Li X, Uquillas C, Mutton LN, Rubin EH, Bieberich CJ.

J Biol Chem. 2008 Feb 22;283(8):4834-40. Epub 2007 Dec 12.

PMID:
18077445
14.

Plk1 phosphorylation of Topors is involved in its degradation.

Yang X, Li H, Deng A, Liu X.

Mol Biol Rep. 2010 Jul;37(6):3023-8. doi: 10.1007/s11033-009-9871-1. Epub 2009 Oct 11.

PMID:
19821153
15.

TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.

Czub B, Shah AZ, Alfano G, Kruczek PM, Chakarova CF, Bhattacharya SS.

PLoS One. 2016 Feb 12;11(2):e0148678. doi: 10.1371/journal.pone.0148678. eCollection 2016.

PMID:
26872363
16.
17.

Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.

Moon SH, Lin L, Zhang X, Nguyen TA, Darlington Y, Waldman AS, Lu X, Donehower LA.

J Biol Chem. 2010 Apr 23;285(17):12935-47. doi: 10.1074/jbc.M109.071696. Epub 2010 Jan 29.

PMID:
20118229
18.

Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A.

Nazarov IB, Smirnova AN, Krutilina RI, Svetlova MP, Solovjeva LV, Nikiforov AA, Oei SL, Zalenskaya IA, Yau PM, Bradbury EM, Tomilin NV.

Radiat Res. 2003 Sep;160(3):309-17.

PMID:
12926989
19.

TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein.

Chakarova CF, Khanna H, Shah AZ, Patil SB, Sedmak T, Murga-Zamalloa CA, Papaioannou MG, Nagel-Wolfrum K, Lopez I, Munro P, Cheetham M, Koenekoop RK, Rios RM, Matter K, Wolfrum U, Swaroop A, Bhattacharya SS.

Hum Mol Genet. 2011 Mar 1;20(5):975-87. doi: 10.1093/hmg/ddq543. Epub 2010 Dec 15.

PMID:
21159800
20.

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y.

J Biol Chem. 2003 May 30;278(22):20303-12. Epub 2003 Mar 25.

PMID:
12660252

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