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Items: 1 to 20 of 73

1.

Integrin-linked kinase (ILK) modulates wound healing through regulation of hepatocyte growth factor (HGF).

Serrano I, Díez-Marqués ML, Rodríguez-Puyol M, Herrero-Fresneda I, Raimundo García del M, Dedhar S, Ruiz-Torres MP, Rodríguez-Puyol D.

Exp Cell Res. 2012 Nov 15;318(19):2470-81. doi: 10.1016/j.yexcr.2012.08.001. Epub 2012 Aug 23.

PMID:
22971619
2.

HGF accelerates wound healing by promoting the dedifferentiation of epidermal cells through β1-integrin/ILK pathway.

Li JF, Duan HF, Wu CT, Zhang DJ, Deng Y, Yin HL, Han B, Gong HC, Wang HW, Wang YL.

Biomed Res Int. 2013;2013:470418. doi: 10.1155/2013/470418. Epub 2014 Jan 15.

3.

ILK-PI3K/AKT pathway participates in cutaneous wound contraction by regulating fibroblast migration and differentiation to myofibroblast.

Li G, Li YY, Sun JE, Lin WH, Zhou RX.

Lab Invest. 2016 Jul;96(7):741-51. doi: 10.1038/labinvest.2016.48. Epub 2016 Apr 25.

4.

ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling.

Qian Y, Zhong X, Flynn DC, Zheng JZ, Qiao M, Wu C, Dedhar S, Shi X, Jiang BH.

Oncogene. 2005 Apr 28;24(19):3154-65.

PMID:
15735674
5.

Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation.

Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R, Dedhar S.

J Biol Chem. 2003 Jun 20;278(25):22374-8. Epub 2003 Apr 8.

6.
7.

Integrin-linked kinase--essential roles in physiology and cancer biology.

McDonald PC, Fielding AB, Dedhar S.

J Cell Sci. 2008 Oct 1;121(Pt 19):3121-32. doi: 10.1242/jcs.017996. Review.

8.

The role of integrin-linked kinase in liver wound healing.

Shafiei MS, Rockey DC.

J Biol Chem. 2006 Aug 25;281(34):24863-72. Epub 2006 May 24.

9.

The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts.

Chen CC, Mo FE, Lau LF.

J Biol Chem. 2001 Dec 14;276(50):47329-37. Epub 2001 Oct 2.

10.

Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - role of TGFβ1 levels and RhoA activity.

Blumbach K, Zweers MC, Brunner G, Peters AS, Schmitz M, Schulz JN, Schild A, Denton CP, Sakai T, Fässler R, Krieg T, Eckes B.

J Cell Sci. 2010 Nov 15;123(Pt 22):3872-83. doi: 10.1242/jcs.063024. Epub 2010 Oct 27.

11.
12.

Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.

Koul D, Shen R, Bergh S, Lu Y, de Groot JF, Liu TJ, Mills GB, Yung WK.

Mol Cancer Ther. 2005 Nov;4(11):1681-8.

13.

Hepatocyte growth factor stimulates proliferation and migration during wound healing of retinal pigment epithelial cells in vitro.

Miura Y, Yanagihara N, Imamura H, Kaida M, Moriwaki M, Shiraki K, Miki T.

Jpn J Ophthalmol. 2003 May-Jun;47(3):268-75.

PMID:
12782163
14.

Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells.

Wojta J, Kaun C, Breuss JM, Koshelnick Y, Beckmann R, Hattey E, Mildner M, Weninger W, Nakamura T, Tschachler E, Binder BR.

Lab Invest. 1999 Apr;79(4):427-38.

PMID:
10211995
15.

Alternative proteolytic processing of hepatocyte growth factor during wound repair.

Buchstein N, Hoffmann D, Smola H, Lang S, Paulsson M, Niemann C, Krieg T, Eming SA.

Am J Pathol. 2009 Jun;174(6):2116-28. doi: 10.2353/ajpath.2009.080597. Epub 2009 Apr 23.

17.

The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.

D'Amico M, Hulit J, Amanatullah DF, Zafonte BT, Albanese C, Bouzahzah B, Fu M, Augenlicht LH, Donehower LA, Takemaru K, Moon RT, Davis R, Lisanti MP, Shtutman M, Zhurinsky J, Ben-Ze'ev A, Troussard AA, Dedhar S, Pestell RG.

J Biol Chem. 2000 Oct 20;275(42):32649-57.

18.

Integrin-linked kinase: a possible role in scar contracture.

Levinson H, Turner CE, Ehrlich HP.

Ann Plast Surg. 2004 Feb;52(2):204-11.

PMID:
14745274
19.

Integrin-linked kinase (ILK): a "hot" therapeutic target.

Yoganathan TN, Costello P, Chen X, Jabali M, Yan J, Leung D, Zhang Z, Yee A, Dedhar S, Sanghera J.

Biochem Pharmacol. 2000 Oct 15;60(8):1115-9. Review.

PMID:
11007949
20.

Deletion of integrin linked kinase in endothelial cells results in defective RTK signaling caused by caveolin 1 mislocalization.

Malan D, Elischer A, Hesse M, Wickström SA, Fleischmann BK, Bloch W.

Development. 2013 Mar;140(5):987-95. doi: 10.1242/dev.091298.

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