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Items: 1 to 20 of 138

1.

Human cytomegalovirus induces TLR4 signaling components in monocytes altering TIRAP, TRAM and downstream interferon-beta and TNF-alpha expression.

Yew KH, Carpenter C, Duncan RS, Harrison CJ.

PLoS One. 2012;7(9):e44500. doi: 10.1371/journal.pone.0044500. Epub 2012 Sep 7.

3.

TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.

Ohnishi H, Tochio H, Kato Z, Kawamoto N, Kimura T, Kubota K, Yamamoto T, Funasaka T, Nakano H, Wong RW, Shirakawa M, Kondo N.

PLoS One. 2012;7(6):e38423. doi: 10.1371/journal.pone.0038423. Epub 2012 Jun 7.

4.

Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.

Lysakova-Devine T, Keogh B, Harrington B, Nagpal K, Halle A, Golenbock DT, Monie T, Bowie AG.

J Immunol. 2010 Oct 1;185(7):4261-71. doi: 10.4049/jimmunol.1002013. Epub 2010 Aug 27.

5.

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.

Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S.

Nat Immunol. 2003 Nov;4(11):1144-50. Epub 2003 Oct 12.

7.

TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

Toshchakov V, Jones BW, Perera PY, Thomas K, Cody MJ, Zhang S, Williams BR, Major J, Hamilton TA, Fenton MJ, Vogel SN.

Nat Immunol. 2002 Apr;3(4):392-8. Epub 2002 Mar 18.

PMID:
11896392
8.

Microbial recognition by Toll-like receptors.

Takeda K, Akira S.

J Dermatol Sci. 2004 Apr;34(2):73-82. Review.

PMID:
15033189
9.

Anti-CD14 antibody reduces LPS responsiveness via TLR4 internalization in human monocytes.

Kim D, Kim JY.

Mol Immunol. 2014 Feb;57(2):210-5. doi: 10.1016/j.molimm.2013.09.009. Epub 2013 Oct 26.

PMID:
24172224
10.

MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.

Verstak B, Nagpal K, Bottomley SP, Golenbock DT, Hertzog PJ, Mansell A.

J Biol Chem. 2009 Sep 4;284(36):24192-203. doi: 10.1074/jbc.M109.023044. Epub 2009 Jul 10.

11.

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.

Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S.

J Immunol. 2002 Dec 15;169(12):6668-72.

15.
16.

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.

Horng T, Barton GM, Flavell RA, Medzhitov R.

Nature. 2002 Nov 21;420(6913):329-33.

PMID:
12447442
17.

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.

Tanimura N, Saitoh S, Matsumoto F, Akashi-Takamura S, Miyake K.

Biochem Biophys Res Commun. 2008 Mar 28;368(1):94-9. doi: 10.1016/j.bbrc.2008.01.061. Epub 2008 Jan 28.

PMID:
18222170
18.

TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.

Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T.

J Biol Chem. 2003 Dec 12;278(50):49751-62. Epub 2003 Sep 30.

19.

TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules.

Matsunaga N, Tsuchimori N, Matsumoto T, Ii M.

Mol Pharmacol. 2011 Jan;79(1):34-41. doi: 10.1124/mol.110.068064. Epub 2010 Sep 29.

20.

TRAM is required for TLR2 endosomal signaling to type I IFN induction.

Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG.

J Immunol. 2014 Dec 15;193(12):6090-102. doi: 10.4049/jimmunol.1401605. Epub 2014 Nov 10.

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