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Items: 1 to 20 of 161

1.

Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development.

Aref D, Moffatt CJ, Agnihotri S, Ramaswamy V, Dubuc AM, Northcott PA, Taylor MD, Perry A, Olson JM, Eberhart CG, Croul SE.

Brain Pathol. 2013 Mar;23(2):178-91. doi: 10.1111/j.1750-3639.2012.00631.x.

PMID:
22966790
2.

Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression.

Milla LA, Arros A, Espinoza N, Remke M, Kool M, Taylor MD, Pfister SM, Wainwright BJ, Palma V.

Int J Cancer. 2014 Jan 1;134(1):21-31. doi: 10.1002/ijc.28330.

3.

Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice.

Rao G, Pedone CA, Del Valle L, Reiss K, Holland EC, Fults DW.

Oncogene. 2004 Aug 12;23(36):6156-62.

PMID:
15195141
4.

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

Faria CC, Golbourn BJ, Dubuc AM, Remke M, Diaz RJ, Agnihotri S, Luck A, Sabha N, Olsen S, Wu X, Garzia L, Ramaswamy V, Mack SC, Wang X, Leadley M, Reynaud D, Ermini L, Post M, Northcott PA, Pfister SM, Croul SE, Kool M, Korshunov A, Smith CA, Taylor MD, Rutka JT.

Cancer Res. 2015 Jan 1;75(1):134-46. doi: 10.1158/0008-5472.CAN-13-3629.

5.

The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors.

Northcott PA, Fernandez-L A, Hagan JP, Ellison DW, Grajkowska W, Gillespie Y, Grundy R, Van Meter T, Rutka JT, Croce CM, Kenney AM, Taylor MD.

Cancer Res. 2009 Apr 15;69(8):3249-55. doi: 10.1158/0008-5472.CAN-08-4710.

6.

MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma.

Bai AH, Milde T, Remke M, Rolli CG, Hielscher T, Cho YJ, Kool M, Northcott PA, Jugold M, Bazhin AV, Eichmüller SB, Kulozik AE, Pscherer A, Benner A, Taylor MD, Pomeroy SL, Kemkemer R, Witt O, Korshunov A, Lichter P, Pfister SM.

Acta Neuropathol. 2012 Apr;123(4):529-38. doi: 10.1007/s00401-011-0924-x.

PMID:
22134538
7.

A novel role of cyclinD1 and p16 in clinical pathology and prognosis of childhood medulloblastoma.

Zhao X, Song T, He Z, Tang L, Zhu Y.

Med Oncol. 2010 Sep;27(3):985-91. doi: 10.1007/s12032-009-9320-y.

PMID:
19806481
8.

WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma.

Doucette TA, Yang Y, Pedone C, Kim JY, Dubuc A, Northcott PD, Taylor MD, Fults DW, Rao G.

Neurosurgery. 2012 Apr;70(4):1003-10; discussion 1010. doi: 10.1227/NEU.0b013e31823e5332.

9.

Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma.

Al-Halabi H, Nantel A, Klekner A, Guiot MC, Albrecht S, Hauser P, Garami M, Bognar L, Kavan P, Gerges N, Shirinian M, Roberge D, Muanza T, Jabado N.

Acta Neuropathol. 2011 Feb;121(2):229-39. doi: 10.1007/s00401-010-0780-0.

PMID:
21107850
10.

Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth.

Binning MJ, Niazi T, Pedone CA, Lal B, Eberhart CG, Kim KJ, Laterra J, Fults DW.

Cancer Res. 2008 Oct 1;68(19):7838-45. doi: 10.1158/0008-5472.CAN-08-1899.

11.

Sox2 requirement in sonic hedgehog-associated medulloblastoma.

Ahlfeld J, Favaro R, Pagella P, Kretzschmar HA, Nicolis S, Schüller U.

Cancer Res. 2013 Jun 15;73(12):3796-807. doi: 10.1158/0008-5472.CAN-13-0238.

12.

Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells.

Hartmann W, Koch A, Brune H, Waha A, Schüller U, Dani I, Denkhaus D, Langmann W, Bode U, Wiestler OD, Schilling K, Pietsch T.

Am J Pathol. 2005 Apr;166(4):1153-62.

13.

Neurotrophin receptors and heparanase: a functional axis in human medulloblastoma invasion.

Marchetti D, Mrak RE, Paulsen DD, Sinnappah-Kang ND.

J Exp Clin Cancer Res. 2007 Mar;26(1):5-23.

PMID:
17550129
14.

β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma.

Zinke J, Schneider FT, Harter PN, Thom S, Ziegler N, Toftgård R, Plate KH, Liebner S.

Mol Cancer. 2015 Feb 3;14:17. doi: 10.1186/s12943-015-0294-4.

15.

Paired box gene 8 (PAX8) expression is associated with sonic hedgehog (SHH)/wingless int (WNT) subtypes, desmoplastic histology and patient survival in human medulloblastomas.

Harter PN, Baumgarten P, Zinke J, Schilling K, Baader S, Hartmetz AK, Schittenhelm J, Beschorner R, Liebner S, Schulte D, Plate KH, Gutwein P, Korshunov A, Pfister SM, Jones DT, Doberstein K, Mittelbronn M.

Neuropathol Appl Neurobiol. 2015 Feb;41(2):165-79. doi: 10.1111/nan.12186.

PMID:
25287489
16.

Wnt/β-catenin signaling inhibits the Shh pathway and impairs tumor growth in Shh-dependent medulloblastoma.

Pöschl J, Bartels M, Ohli J, Bianchi E, Kuteykin-Teplyakov K, Grammel D, Ahlfeld J, Schüller U.

Acta Neuropathol. 2014 Apr;127(4):605-7. doi: 10.1007/s00401-014-1258-2. No abstract available.

PMID:
24531885
17.
18.

The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas.

Hallahan AR, Pritchard JI, Hansen S, Benson M, Stoeck J, Hatton BA, Russell TL, Ellenbogen RG, Bernstein ID, Beachy PA, Olson JM.

Cancer Res. 2004 Nov 1;64(21):7794-800.

19.

Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.

Parathath SR, Mainwaring LA, Fernandez-L A, Campbell DO, Kenney AM.

Development. 2008 Oct;135(19):3291-300. doi: 10.1242/dev.022871.

20.

Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration.

Yuan L, Zhang H, Liu J, Rubin JB, Cho YJ, Shu HK, Schniederjan M, MacDonald TJ.

Mol Cancer. 2013 Mar 5;12:18. doi: 10.1186/1476-4598-12-18.

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