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Items: 1 to 20 of 167


Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel.

Haerteis S, Krappitz M, Diakov A, Krappitz A, Rauh R, Korbmacher C.

J Gen Physiol. 2012 Oct;140(4):375-89. Epub 2012 Sep 10.


Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels.

Diakov A, Bera K, Mokrushina M, Krueger B, Korbmacher C.

J Physiol. 2008 Oct 1;586(19):4587-608. doi: 10.1113/jphysiol.2008.154435. Epub 2008 Jul 31.


Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites.

Haerteis S, Krappitz A, Krappitz M, Murphy JE, Bertog M, Krueger B, Nacken R, Chung H, Hollenberg MD, Knecht W, Bunnett NW, Korbmacher C.

J Biol Chem. 2014 Jul 4;289(27):19067-78. doi: 10.1074/jbc.M113.538470. Epub 2014 May 19.


Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S.

Haerteis S, Krappitz M, Bertog M, Krappitz A, Baraznenok V, Henderson I, Lindström E, Murphy JE, Bunnett NW, Korbmacher C.

Pflugers Arch. 2012 Oct;464(4):353-65. Epub 2012 Aug 5.


The delta-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation.

Haerteis S, Krueger B, Korbmacher C, Rauh R.

J Biol Chem. 2009 Oct 16;284(42):29024-40. doi: 10.1074/jbc.M109.018945. Epub 2009 Aug 28.


Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations.

Svenningsen P, Uhrenholt TR, Palarasah Y, Skjødt K, Jensen BL, Skøtt O.

Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1733-41. doi: 10.1152/ajpregu.00321.2009. Epub 2009 Sep 30.


TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site.

Passero CJ, Mueller GM, Myerburg MM, Carattino MD, Hughey RP, Kleyman TR.

Am J Physiol Renal Physiol. 2012 Jan 1;302(1):F1-8. doi: 10.1152/ajprenal.00330.2011. Epub 2011 Oct 12.


Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.

Passero CJ, Mueller GM, Rondon-Berrios H, Tofovic SP, Hughey RP, Kleyman TR.

J Biol Chem. 2008 Dec 26;283(52):36586-91. doi: 10.1074/jbc.M805676200. Epub 2008 Nov 3.


Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation.

Carattino MD, Hughey RP, Kleyman TR.

J Biol Chem. 2008 Sep 12;283(37):25290-5. doi: 10.1074/jbc.M803931200. Epub 2008 Jul 23.


Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second protease.

Carattino MD, Mueller GM, Palmer LG, Frindt G, Rued AC, Hughey RP, Kleyman TR.

Am J Physiol Renal Physiol. 2014 Nov 1;307(9):F1080-7. doi: 10.1152/ajprenal.00157.2014. Epub 2014 Sep 10.


ENaC proteolytic regulation by channel-activating protease 2.

García-Caballero A, Dang Y, He H, Stutts MJ.

J Gen Physiol. 2008 Nov;132(5):521-35. doi: 10.1085/jgp.200810030. Epub 2008 Oct 13.


Preferential assembly of epithelial sodium channel (ENaC) subunits in Xenopus oocytes: role of furin-mediated endogenous proteolysis.

Harris M, Garcia-Caballero A, Stutts MJ, Firsov D, Rossier BC.

J Biol Chem. 2008 Mar 21;283(12):7455-63. doi: 10.1074/jbc.M707399200. Epub 2008 Jan 14.


A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition.

Rauh R, Diakov A, Tzschoppe A, Korbmacher J, Azad AK, Cuppens H, Cassiman JJ, Dötsch J, Sticht H, Korbmacher C.

J Physiol. 2010 Apr 15;588(Pt 8):1211-25. doi: 10.1113/jphysiol.2009.180224. Epub 2010 Mar 1.


Tissue kallikrein activation of the epithelial Na channel.

Patel AB, Chao J, Palmer LG.

Am J Physiol Renal Physiol. 2012 Aug 15;303(4):F540-50. doi: 10.1152/ajprenal.00133.2012. Epub 2012 May 23.


Plasmin in nephrotic urine activates the epithelial sodium channel.

Svenningsen P, Bistrup C, Friis UG, Bertog M, Haerteis S, Krueger B, Stubbe J, Jensen ON, Thiesson HC, Uhrenholt TR, Jespersen B, Jensen BL, Korbmacher C, Skøtt O.

J Am Soc Nephrol. 2009 Feb;20(2):299-310. doi: 10.1681/ASN.2008040364. Epub 2008 Dec 10.


A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect.

Rauh R, Soell D, Haerteis S, Diakov A, Nesterov V, Krueger B, Sticht H, Korbmacher C.

Am J Physiol Lung Cell Mol Physiol. 2013 Jan 1;304(1):L43-55. doi: 10.1152/ajplung.00093.2012. Epub 2012 Oct 19.


Physiological regulation of epithelial sodium channel by proteolysis.

Svenningsen P, Friis UG, Bistrup C, Buhl KB, Jensen BL, Skøtt O.

Curr Opin Nephrol Hypertens. 2011 Sep;20(5):529-33. doi: 10.1097/MNH.0b013e328348bcc7. Review.


Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites.

Ji HL, Zhao R, Komissarov AA, Chang Y, Liu Y, Matthay MA.

J Biol Chem. 2015 Feb 27;290(9):5241-55. doi: 10.1074/jbc.M114.623496. Epub 2015 Jan 2.


Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells.

Andersen H, Friis UG, Hansen PB, Svenningsen P, Henriksen JE, Jensen BL.

Nephrol Dial Transplant. 2015 May;30(5):781-9. doi: 10.1093/ndt/gfu402. Epub 2015 Jan 20.


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