Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 262

1.

Genome-wide analysis of pain-, nerve- and neurotrophin -related gene expression in the degenerating human annulus.

Gruber HE, Hoelscher GL, Ingram JA, Hanley EN Jr.

Mol Pain. 2012 Sep 10;8:63. doi: 10.1186/1744-8069-8-63.

2.

Mitochondrial gene expression in the human annulus: in vivo data from annulus cells and selectively harvested senescent annulus cells.

Gruber HE, Watts JA, Hoelscher GL, Bethea SF, Ingram JA, Zinchenko NS, Hanley EN Jr.

Spine J. 2011 Aug;11(8):782-91. doi: 10.1016/j.spinee.2011.06.012. Epub 2011 Jul 23.

PMID:
21784712
3.

Matrix metalloproteinase 28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discs.

Gruber HE, Ingram JA, Hoelscher GL, Zinchenko N, Norton HJ, Hanley EN Jr.

Arthritis Res Ther. 2009;11(6):R184. doi: 10.1186/ar2876. Epub 2009 Dec 9.

4.

Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs.

Gruber HE, Hoelscher GL, Hanley EN Jr.

Spine J. 2010 Aug;10(8):721-7. doi: 10.1016/j.spinee.2010.05.014.

PMID:
20650410
5.

Variations in aggrecan localization and gene expression patterns characterize increasing stages of human intervertebral disk degeneration.

Gruber HE, Hoelscher GL, Ingram JA, Bethea S, Zinchenko N, Hanley EN Jr.

Exp Mol Pathol. 2011 Oct;91(2):534-9. doi: 10.1016/j.yexmp.2011.06.001. Epub 2011 Jun 12.

PMID:
21689646
6.

Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration.

Binch AL, Cole AA, Breakwell LM, Michael AL, Chiverton N, Cross AK, Le Maitre CL.

Arthritis Res Ther. 2014 Aug 20;16(5):416. doi: 10.1186/s13075-014-0416-1.

7.
8.

High-mobility group box-1 gene, a potent proinflammatory mediators, is upregulated in more degenerated human discs in vivo and its receptor upregulated by TNF-α exposure in vitro.

Gruber HE, Hoelscher GL, Bethea S, Ingram J, Cox M, Hanley EN Jr.

Exp Mol Pathol. 2015 Jun;98(3):427-30. doi: 10.1016/j.yexmp.2015.03.001. Epub 2015 Mar 4.

PMID:
25746662
9.

Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand.

Gruber HE, Ingram JA, Hoelscher GL, Zinchenko N, Norton HJ, Hanley EN Jr.

Arthritis Res Ther. 2011 Aug 31;13(4):R140. doi: 10.1186/ar3454.

10.

Comparative expression of matrix-associated genes and inflammatory cytokines-associated genes according to disc degeneration: analysis of living human nucleus pulposus.

Park JY, Kuh SU, Park HS, Kim KS.

J Spinal Disord Tech. 2011 Aug;24(6):352-7. doi: 10.1097/BSD.0b013e3181fee4df.

PMID:
21150669
11.

Expression and relationship of proinflammatory chemokine RANTES/CCL5 and cytokine IL-1β in painful human intervertebral discs.

Kepler CK, Markova DZ, Dibra F, Yadla S, Vaccaro AR, Risbud MV, Albert TJ, Anderson DG.

Spine (Phila Pa 1976). 2013 May 15;38(11):873-80. doi: 10.1097/BRS.0b013e318285ae08.

PMID:
23660804
12.

Mitochondrial bioenergetics, mass, and morphology are altered in cells of the degenerating human annulus.

Gruber HE, Watts JA, Riley FE, Fulkerson MB, Norton HJ, Hanley EN Jr.

J Orthop Res. 2013 Aug;31(8):1270-5. doi: 10.1002/jor.22361. Epub 2013 Apr 10.

13.

Matrix metalloproteinase-26, a novel MMP, is constitutively expressed in the human intervertebral disc in vivo and in vitro.

Gruber HE, Hoelscher GL, Ingram JA, Hanley EN Jr.

Exp Mol Pathol. 2012 Feb;92(1):59-63. doi: 10.1016/j.yexmp.2011.09.008. Epub 2011 Sep 14.

PMID:
21945733
14.

Increased cell senescence is associated with decreased cell proliferation in vivo in the degenerating human annulus.

Gruber HE, Ingram JA, Davis DE, Hanley EN Jr.

Spine J. 2009 Mar;9(3):210-5. doi: 10.1016/j.spinee.2008.01.012. Epub 2008 Apr 25.

PMID:
18440281
15.

Mitochondrial Membrane Potential and Nuclear and Gene Expression Changes During Human Disc Cell Apoptosis: In Vitro and In Vivo Annulus Findings.

Gruber HE, Hoelscher GL, Bethea S, Hanley EN Jr.

Spine (Phila Pa 1976). 2015 Jun 15;40(12):876-82. doi: 10.1097/BRS.0000000000000936.

PMID:
25909354
16.

Increased IL-17 expression in degenerated human discs and increased production in cultured annulus cells exposed to IL-1ß and TNF-α.

Gruber HE, Hoelscher GL, Ingram JA, Norton HJ, Hanley EN Jr.

Biotech Histochem. 2013 Aug;88(6):302-10. doi: 10.3109/10520295.2013.783235. Epub 2013 Apr 30.

PMID:
23627571
17.

Pharmacological enhancement of disc diffusion and differentiation of healthy, ageing and degenerated discs : Results from in-vivo serial post-contrast MRI studies in 365 human lumbar discs.

Rajasekaran S, Venkatadass K, Naresh Babu J, Ganesh K, Shetty AP.

Eur Spine J. 2008 May;17(5):626-43. doi: 10.1007/s00586-008-0645-6. Epub 2008 Mar 21.

18.

Ex vivo observation of human intervertebral disc tissue and cells isolated from degenerated intervertebral discs.

Ciapetti G, Granchi D, Devescovi V, Leonardi E, Greggi T, Di Silvestre M, Baldini N.

Eur Spine J. 2012 May;21 Suppl 1:S10-9. doi: 10.1007/s00586-012-2234-y. Epub 2012 Mar 7.

19.

Growth and differentiation factor-5 (GDF-5) in the human intervertebral annulus cells and its modulation by IL-1ß and TNF-α in vitro.

Gruber HE, Hoelscher GL, Ingram JA, Bethea S, Hanley EN Jr.

Exp Mol Pathol. 2014 Apr;96(2):225-9. doi: 10.1016/j.yexmp.2014.02.005. Epub 2014 Feb 25.

PMID:
24582800
20.

Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis.

Zhang Z, Kakutani K, Maeno K, Takada T, Yurube T, Doita M, Kurosaka M, Nishida K.

Arthritis Res Ther. 2011;13(6):R200. doi: 10.1186/ar3533. Epub 2011 Dec 8.

Supplemental Content

Support Center