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Items: 1 to 20 of 91

1.

A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor.

Craik CS, Shahian T.

Methods Mol Biol. 2012;928:119-31. doi: 10.1007/978-1-62703-008-3_9.

2.

Inhibition of a viral enzyme by a small-molecule dimer disruptor.

Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS.

Nat Chem Biol. 2009 Sep;5(9):640-6. doi: 10.1038/nchembio.192.

3.

Broad-spectrum allosteric inhibition of herpesvirus proteases.

Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS.

Biochemistry. 2014 Jul 22;53(28):4648-60. doi: 10.1021/bi5003234.

4.

Herpesvirus protease inhibition by dimer disruption.

Shimba N, Nomura AM, Marnett AB, Craik CS.

J Virol. 2004 Jun;78(12):6657-65.

5.
6.

Enzyme inhibition by allosteric capture of an inactive conformation.

Lee GM, Shahian T, Baharuddin A, Gable JE, Craik CS.

J Mol Biol. 2011 Sep 2;411(5):999-1016. doi: 10.1016/j.jmb.2011.06.032.

7.

Conformational change coupling the dimerization and activation of KSHV protease.

Pray TR, Reiling KK, Demirjian BG, Craik CS.

Biochemistry. 2002 Feb 5;41(5):1474-82.

PMID:
11814340
8.

Auto-inactivation by cleavage within the dimer interface of Kaposi's sarcoma-associated herpesvirus protease.

Pray TR, Nomura AM, Pennington MW, Craik CS.

J Mol Biol. 1999 Jun 4;289(2):197-203.

PMID:
10366498
9.

Protease dimer formation disrupted.

Chmielewski J.

Nat Chem Biol. 2009 Sep;5(9):607-8. doi: 10.1038/nchembio0909-607.

PMID:
19690531
10.

Discovery libraries targeting the major enzyme classes: the serine hydrolases.

Otrubova K, Srinivasan V, Boger DL.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3807-13. doi: 10.1016/j.bmcl.2014.06.063.

11.

In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound.

Bouillon A, Giganti D, Benedet C, Gorgette O, Pêtres S, Crublet E, Girard-Blanc C, Witkowski B, Ménard D, Nilges M, Mercereau-Puijalon O, Stoven V, Barale JC.

J Biol Chem. 2013 Jun 21;288(25):18561-73. doi: 10.1074/jbc.M113.456764.

12.

Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor.

Marnett AB, Nomura AM, Shimba N, Ortiz de Montellano PR, Craik CS.

Proc Natl Acad Sci U S A. 2004 May 4;101(18):6870-5.

13.

One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease.

Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS.

Biochemistry. 2006 Mar 21;45(11):3572-9.

PMID:
16533039
14.

Ahp cyclodepsipeptides: the impact of the Ahp residue on the "canonical inhibition" of S1 serine proteases.

Stolze SC, Meltzer M, Ehrmann M, Kaiser M.

Chembiochem. 2013 Jul 22;14(11):1301-8. doi: 10.1002/cbic.201300180.

PMID:
23794257
15.

The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8).

Unal A, Pray TR, Lagunoff M, Pennington MW, Ganem D, Craik CS.

J Virol. 1997 Sep;71(9):7030-8.

16.

Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease.

Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS.

ChemMedChem. 2016 Apr 19;11(8):862-9. doi: 10.1002/cmdc.201500526.

PMID:
26822284
17.

Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease.

Zühlsdorf M, Werten S, Klupp BG, Palm GJ, Mettenleiter TC, Hinrichs W.

PLoS Pathog. 2015 Jul 10;11(7):e1005045. doi: 10.1371/journal.ppat.1005045. Erratum in: PLoS Pathog. 2016 Mar;12(3):e1005506.

18.

Structural and mechanistic insight into how antibodies inhibit serine proteases.

Ganesan R, Eigenbrot C, Kirchhofer D.

Biochem J. 2010 Sep 1;430(2):179-89. doi: 10.1042/BJ20100634. Review.

PMID:
20704569
19.

Kaposi's Sarcoma (KS)-associated herpesvirus and its role in KS.

Chang Y, Moore PS.

Infect Agents Dis. 1996 Oct;5(4):215-22. Review.

PMID:
8884366
20.

α-Amino-α'-halomethylketones: synthetic methodologies and pharmaceutical applications as serine and cysteine protease inhibitors.

Pace V, Castoldi L, Pregnolato M.

Mini Rev Med Chem. 2013 Jun;13(7):988-96. Review.

PMID:
22931530
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