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Items: 1 to 20 of 85

1.

Rational design of Rho GTPase-targeting inhibitors.

Shang X, Zheng Y.

Methods Mol Biol. 2012;928:29-38. doi: 10.1007/978-1-62703-008-3_3.

PMID:
22956131
2.

Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases.

Shang X, Marchioni F, Sipes N, Evelyn CR, Jerabek-Willemsen M, Duhr S, Seibel W, Wortman M, Zheng Y.

Chem Biol. 2012 Jun 22;19(6):699-710. doi: 10.1016/j.chembiol.2012.05.009.

3.

Structure-function based design of small molecule inhibitors targeting Rho family GTPases.

Nassar N, Cancelas J, Zheng J, Williams DA, Zheng Y.

Curr Top Med Chem. 2006;6(11):1109-16. Review.

PMID:
16842149
4.

Automated NMR fragment based screening identified a novel interface blocker to the LARG/RhoA complex.

Gao J, Ma R, Wang W, Wang N, Sasaki R, Snyderman D, Wu J, Ruan K.

PLoS One. 2014 Feb 5;9(2):e88098. doi: 10.1371/journal.pone.0088098. eCollection 2014.

5.

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors.

Shang X, Marchioni F, Evelyn CR, Sipes N, Zhou X, Seibel W, Wortman M, Zheng Y.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60. doi: 10.1073/pnas.1212324110. Epub 2013 Feb 4.

6.
7.

Targeting rho GTPases by peptidic structures.

Marchioni F, Zheng Y.

Curr Pharm Des. 2009;15(21):2481-7. Review.

PMID:
19601845
8.

Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA.

Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ.

J Biol Chem. 2001 Jul 20;276(29):27145-51. Epub 2001 May 23.

9.

Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.

Debreceni B, Gao Y, Guo F, Zhu K, Jia B, Zheng Y.

J Biol Chem. 2004 Jan 30;279(5):3777-86. Epub 2003 Nov 3.

10.

High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay.

Evelyn CR, Ferng T, Rojas RJ, Larsen MJ, Sondek J, Neubig RR.

J Biomol Screen. 2009 Feb;14(2):161-72. doi: 10.1177/1087057108328761. Epub 2009 Feb 4.

11.

Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors.

Heo J, Thapar R, Campbell SL.

Biochemistry. 2005 May 3;44(17):6573-85.

PMID:
15850391
12.

Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.

Kristelly R, Gao G, Tesmer JJ.

J Biol Chem. 2004 Nov 5;279(45):47352-62. Epub 2004 Aug 25.

13.

Thiol-modifying phenylarsine oxide inhibits guanine nucleotide binding of Rho but not of Rac GTPases.

Gerhard R, John H, Aktories K, Just I.

Mol Pharmacol. 2003 Jun;63(6):1349-55.

14.

Leukemia-associated Rho guanine-nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice.

Williams CM, Harper MT, Goggs R, Walsh TG, Offermanns S, Poole AW.

J Thromb Haemost. 2015 Nov;13(11):2102-7. doi: 10.1111/jth.13129. Epub 2015 Oct 20.

15.

Identification of the first Rho-GEF inhibitor, TRIPalpha, which targets the RhoA-specific GEF domain of Trio.

Schmidt S, Diriong S, Méry J, Fabbrizio E, Debant A.

FEBS Lett. 2002 Jul 17;523(1-3):35-42.

16.

Rho GTPases: promising cellular targets for novel anticancer drugs.

Fritz G, Kaina B.

Curr Cancer Drug Targets. 2006 Feb;6(1):1-14. Review.

PMID:
16475973
17.

cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI.

Tamma G, Klussmann E, Procino G, Svelto M, Rosenthal W, Valenti G.

J Cell Sci. 2003 Apr 15;116(Pt 8):1519-25.

18.

Rational design and applications of a Rac GTPase-specific small molecule inhibitor.

Akbar H, Cancelas J, Williams DA, Zheng J, Zheng Y.

Methods Enzymol. 2006;406:554-65.

PMID:
16472687
20.

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.

Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K.

J Biol Chem. 2002 Nov 8;277(45):42964-72. Epub 2002 Sep 6.

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