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The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma.

Hatzimichael E, Lo Nigro C, Lattanzio L, Syed N, Shah R, Dasoula A, Janczar K, Vivenza D, Monteverde M, Merlano M, Papoudou-Bai A, Bai M, Schmid P, Stebbing J, Bower M, Dyer MJ, Karran LE, ElguetaKarstegl C, Farrell PJ, Thompson A, Briasoulis E, Crook T.

Br J Cancer. 2012 Oct 9;107(8):1423-32. doi: 10.1038/bjc.2012.380. Epub 2012 Sep 6.


Severe Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I.

Aro E, Salo AM, Khatri R, Finnilä M, Miinalainen I, Sormunen R, Pakkanen O, Holster T, Soininen R, Prein C, Clausen-Schaumann H, Aszódi A, Tuukkanen J, Kivirikko KI, Schipani E, Myllyharju J.

J Biol Chem. 2015 Jul 3;290(27):16964-78. doi: 10.1074/jbc.M115.662635. Epub 2015 May 22.


Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity.

Tiainen P, Myllyharju J, Koivunen P.

J Biol Chem. 2005 Jan 14;280(2):1142-8. Epub 2004 Nov 4.


The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia.

Hatzimichael E, Dasoula A, Shah R, Syed N, Papoudou-Bai A, Coley HM, Dranitsaris G, Bourantas KL, Stebbing J, Crook T.

Eur J Haematol. 2010 Jan 1;84(1):47-51. doi: 10.1111/j.1600-0609.2009.01344.x. Epub 2009 Sep 8.


The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer.

Shah R, Smith P, Purdie C, Quinlan P, Baker L, Aman P, Thompson AM, Crook T.

Br J Cancer. 2009 May 19;100(10):1687-96. doi: 10.1038/sj.bjc.6605042.


Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi.

Winter AD, McCormack G, Myllyharju J, Page AP.

J Biol Chem. 2013 Jan 18;288(3):1750-61. doi: 10.1074/jbc.M112.397604. Epub 2012 Dec 6.


Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition.

Xiong G, Deng L, Zhu J, Rychahou PG, Xu R.

BMC Cancer. 2014 Jan 2;14:1. doi: 10.1186/1471-2407-14-1.


Tunable, post-translational hydroxylation of collagen Domains in Escherichia coli.

Pinkas DM, Ding S, Raines RT, Barron AE.

ACS Chem Biol. 2011 Apr 15;6(4):320-4. doi: 10.1021/cb100298r. Epub 2011 Jan 14.


Post-translationally abnormal collagens of prolyl 3-hydroxylase-2 null mice offer a pathobiological mechanism for the high myopia linked to human LEPREL1 mutations.

Hudson DM, Joeng KS, Werther R, Rajagopal A, Weis M, Lee BH, Eyre DR.

J Biol Chem. 2015 Mar 27;290(13):8613-22. doi: 10.1074/jbc.M114.634915. Epub 2015 Feb 2.


Activated proliferation of B-cell lymphomas/leukemias with the SHP1 gene silencing by aberrant CpG methylation.

Koyama M, Oka T, Ouchida M, Nakatani Y, Nishiuchi R, Yoshino T, Hayashi K, Akagi T, Seino Y.

Lab Invest. 2003 Dec;83(12):1849-58.


The peptide-substrate-binding domain of human collagen prolyl 4-hydroxylases. Backbone assignments, secondary structure, and binding of proline-rich peptides.

Hieta R, Kukkola L, Permi P, Pirilä P, Kivirikko KI, Kilpeläinen I, Myllyharju J.

J Biol Chem. 2003 Sep 12;278(37):34966-74. Epub 2003 Jun 24.


An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha.

Koivunen P, Tiainen P, Hyvärinen J, Williams KE, Sormunen R, Klaus SJ, Kivirikko KI, Myllyharju J.

J Biol Chem. 2007 Oct 19;282(42):30544-52. Epub 2007 Aug 27.


Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes.

Vranka JA, Sakai LY, Bächinger HP.

J Biol Chem. 2004 May 28;279(22):23615-21. Epub 2004 Mar 24.


Characterization of a novel Caenorhabditis elegans prolyl 4-hydroxylase with a unique substrate specificity and restricted expression in the pharynx and excretory duct.

Keskiaho K, Kukkola L, Page AP, Winter AD, Vuoristo J, Sormunen R, Nissi R, Riihimaa P, Myllyharju J.

J Biol Chem. 2008 Apr 18;283(16):10679-89. doi: 10.1074/jbc.M800972200. Epub 2008 Feb 13.


Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis.

Myllyharju J.

Matrix Biol. 2003 Mar;22(1):15-24. Review.


Collagen prolyl 3-hydroxylation: a major role for a minor post-translational modification?

Hudson DM, Eyre DR.

Connect Tissue Res. 2013;54(4-5):245-51. doi: 10.3109/03008207.2013.800867. Epub 2013 Jun 21. Review.


Characterization of recombinant human prolyl 3-hydroxylase isoenzyme 2, an enzyme modifying the basement membrane collagen IV.

Tiainen P, Pasanen A, Sormunen R, Myllyharju J.

J Biol Chem. 2008 Jul 11;283(28):19432-9. doi: 10.1074/jbc.M802973200. Epub 2008 May 15.


Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels.

Grimmer C, Balbus N, Lang U, Aigner T, Cramer T, Müller L, Swoboda B, Pfander D.

Am J Pathol. 2006 Aug;169(2):491-502.


CpG methylation of the major Epstein-Barr virus latency promoter in Burkitt's lymphoma and Hodgkin's disease.

Robertson KD, Manns A, Swinnen LJ, Zong JC, Gulley ML, Ambinder RF.

Blood. 1996 Oct 15;88(8):3129-36.

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