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Items: 1 to 20 of 169

1.

Novel aminobenzyl-acetamidine derivative modulate the differential regulation of NOSs in LPS induced inflammatory response: role of PI3K/Akt pathway.

Patruno A, Franceschelli S, Pesce M, Maccallini C, Fantacuzzi M, Speranza L, Ferrone A, De Lutiis MA, Ricciotti E, Amoroso R, Felaco M.

Biochim Biophys Acta. 2012 Dec;1820(12):2095-104. doi: 10.1016/j.bbagen.2012.08.014. Epub 2012 Aug 23.

PMID:
22951221
2.

Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways.

Qi S, Xin Y, Guo Y, Diao Y, Kou X, Luo L, Yin Z.

Int Immunopharmacol. 2012 Jan;12(1):278-87. doi: 10.1016/j.intimp.2011.12.001. Epub 2011 Dec 20.

PMID:
22193240
3.

Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways.

Chiou WF, Don MJ, Liao JF, Wei BL.

Eur J Pharmacol. 2011 Jan 10;650(1):102-9. doi: 10.1016/j.ejphar.2010.10.004. Epub 2010 Oct 14.

PMID:
20951127
4.

Isobutyrylshikonin inhibits lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in BV2 microglial cells by suppressing the PI3K/Akt-mediated nuclear transcription factor-κB pathway.

Jayasooriya RG, Lee KT, Kang CH, Dilshara MG, Lee HJ, Choi YH, Choi IW, Kim GY.

Nutr Res. 2014 Dec;34(12):1111-9. doi: 10.1016/j.nutres.2014.10.002. Epub 2014 Oct 7.

PMID:
25454762
5.

Biological Effect of Licochalcone C on the Regulation of PI3K/Akt/eNOS and NF-κB/iNOS/NO Signaling Pathways in H9c2 Cells in Response to LPS Stimulation.

Franceschelli S, Pesce M, Ferrone A, Gatta DM, Patruno A, Lutiis MA, Quiles JL, Grilli A, Felaco M, Speranza L.

Int J Mol Sci. 2017 Mar 23;18(4). pii: E690. doi: 10.3390/ijms18040690.

6.

The E3 ubiquitin ligase TRAF6 inhibits LPS-induced AKT activation in FLT3-ITD-positive MV4-11 AML cells.

Schnetzke U, Fischer M, Kuhn AK, Spies-Weisshart B, Zirm E, Hochhaus A, Müller JP, Scholl S.

J Cancer Res Clin Oncol. 2013 Apr;139(4):605-15. doi: 10.1007/s00432-012-1362-4. Epub 2012 Dec 21.

PMID:
23263202
7.

The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activation.

Kim JH, Na HJ, Kim CK, Kim JY, Ha KS, Lee H, Chung HT, Kwon HJ, Kwon YG, Kim YM.

Free Radic Biol Med. 2008 Sep 15;45(6):885-96. doi: 10.1016/j.freeradbiomed.2008.06.019. Epub 2008 Jun 27.

PMID:
18620044
8.

Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway.

Xu CQ, Liu BJ, Wu JF, Xu YC, Duan XH, Cao YX, Dong JC.

Eur J Pharmacol. 2010 Sep 10;642(1-3):146-53. doi: 10.1016/j.ejphar.2010.05.012. Epub 2010 May 25.

PMID:
20519138
9.

Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/IKKβ/NF-κB signaling.

Hsing CH, Lin MC, Choi PC, Huang WC, Kai JI, Tsai CC, Cheng YL, Hsieh CY, Wang CY, Chang YP, Chen YH, Chen CL, Lin CF.

PLoS One. 2011 Mar 8;6(3):e17598. doi: 10.1371/journal.pone.0017598.

10.

Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells.

Zhong LM, Zong Y, Sun L, Guo JZ, Zhang W, He Y, Song R, Wang WM, Xiao CJ, Lu D.

PLoS One. 2012;7(2):e32195. doi: 10.1371/journal.pone.0032195. Epub 2012 Feb 21.

11.

Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide.

Zhang L, Wu C, Zhao S, Yuan D, Lian G, Wang X, Wang L, Yang J.

Int Immunopharmacol. 2010 Mar;10(3):331-8. doi: 10.1016/j.intimp.2009.12.004. Epub 2009 Dec 16.

PMID:
20018257
12.

Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells.

Endale M, Park SC, Kim S, Kim SH, Yang Y, Cho JY, Rhee MH.

Immunobiology. 2013 Dec;218(12):1452-67. doi: 10.1016/j.imbio.2013.04.019. Epub 2013 May 9.

PMID:
23735482
13.
15.

Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-κB and MAPKs activation via the phosphatidylinositol 3-kinase signaling.

Yang P, Han Y, Gui L, Sun J, Chen YL, Song R, Guo JZ, Xie YN, Lu D, Sun L.

Biochem Pharmacol. 2013 Apr 15;85(8):1124-33. doi: 10.1016/j.bcp.2013.01.020. Epub 2013 Jan 29.

PMID:
23376120
16.

Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-κB activation and ERK phosphorylation.

Kang CH, Jayasooriya RG, Dilshara MG, Choi YH, Jeong YK, Kim ND, Kim GY.

Food Chem Toxicol. 2012 Dec;50(12):4270-6. doi: 10.1016/j.fct.2012.08.041. Epub 2012 Sep 10.

PMID:
22974838
18.

Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells.

Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX, Song LH.

J Pineal Res. 2012 Nov;53(4):325-34. doi: 10.1111/j.1600-079X.2012.01002.x. Epub 2012 Apr 27.

PMID:
22537289
19.

Desmethylanhydroicaritin inhibits NF-kappaB-regulated inflammatory gene expression by modulating the redox-sensitive PI3K/PTEN/Akt pathway.

Kim JH, Lee G, Cho YL, Kim CK, Han S, Lee H, Choi JS, Choe J, Won MH, Kwon YG, Ha KS, Kim YM.

Eur J Pharmacol. 2009 Jan 14;602(2-3):422-31. doi: 10.1016/j.ejphar.2008.10.062. Epub 2008 Nov 9.

PMID:
19027002
20.

Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-κB signaling pathway for gastric cancer metastasis.

Hao NB, Tang B, Wang GZ, Xie R, Hu CJ, Wang SM, Wu YY, Liu E, Xie X, Yang SM.

Cancer Lett. 2015 May 28;361(1):57-66. doi: 10.1016/j.canlet.2015.02.043. Epub 2015 Feb 26.

PMID:
25727320

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