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Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH.

Englert M, Xia S, Okada C, Nakamura A, Tanavde V, Yao M, Eom SH, Konigsberg WH, Söll D, Wang J.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15235-40.


Structures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation.

Desai KK, Bingman CA, Phillips GN Jr, Raines RT.

Biochemistry. 2013 Apr 16;52(15):2518-25. doi: 10.1021/bi4002375.


tRNA ligase catalyzes the GTP-dependent ligation of RNA with 3'-phosphate and 5'-hydroxyl termini.

Desai KK, Raines RT.

Biochemistry. 2012 Feb 21;51(7):1333-5. doi: 10.1021/bi201921a.


A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation.

Desai KK, Cheng CL, Bingman CA, Phillips GN Jr, Raines RT.

Nucleic Acids Res. 2014 Apr;42(6):3931-42. doi: 10.1093/nar/gkt1375.


RNA ligase RtcB splices 3'-phosphate and 5'-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3')pp(5')G intermediates.

Chakravarty AK, Subbotin R, Chait BT, Shuman S.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6072-7. doi: 10.1073/pnas.1201207109.


RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo.

Tanaka N, Meineke B, Shuman S.

J Biol Chem. 2011 Sep 2;286(35):30253-7. doi: 10.1074/jbc.C111.274597.


Novel mechanism of RNA repair by RtcB via sequential 2',3'-cyclic phosphodiesterase and 3'-Phosphate/5'-hydroxyl ligation reactions.

Tanaka N, Chakravarty AK, Maughan B, Shuman S.

J Biol Chem. 2011 Dec 16;286(50):43134-43. doi: 10.1074/jbc.M111.302133.


Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation.

Englert M, Sheppard K, Aslanian A, Yates JR 3rd, Söll D.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1290-5. doi: 10.1073/pnas.1018307108.


Coevolution of RtcB and Archease created a multiple-turnover RNA ligase.

Desai KK, Beltrame AL, Raines RT.

RNA. 2015 Nov;21(11):1866-72. doi: 10.1261/rna.052639.115.


RtcB is the RNA ligase component of an Escherichia coli RNA repair operon.

Tanaka N, Shuman S.

J Biol Chem. 2011 Mar 11;286(10):7727-31. doi: 10.1074/jbc.C111.219022.


Structure of RNA 3'-phosphate cyclase bound to substrate RNA.

Desai KK, Bingman CA, Cheng CL, Phillips GN Jr, Raines RT.

RNA. 2014 Oct;20(10):1560-6. doi: 10.1261/rna.045823.114.


Rewriting the rules for end joining via enzymatic splicing of DNA 3'-PO4 and 5'-OH ends.

Das U, Chakravarty AK, Remus BS, Shuman S.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20437-42. doi: 10.1073/pnas.1314289110.


Genetic and biochemical analysis of the functional domains of yeast tRNA ligase.

Sawaya R, Schwer B, Shuman S.

J Biol Chem. 2003 Nov 7;278(45):43928-38.


The structure of Pyrococcus horikoshii 2'-5' RNA ligase at 1.94 A resolution reveals a possible open form with a wider active-site cleft.

Gao YG, Yao M, Okada A, Tanaka I.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt 12):1196-200.


The structure of Rph, an exoribonuclease from Bacillus anthracis, at 1.7 A resolution.

Rawlings AE, Blagova EV, Levdikov VM, Fogg MJ, Wilson KS, Wilkinson AJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jan 1;65(Pt 1):2-7. doi: 10.1107/S1744309108041511.

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