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TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection.

Wang Z, Fayngerts S, Wang P, Sun H, Johnson DS, Ruan Q, Guo W, Chen YH.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15413-8. Epub 2012 Sep 4.


TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway.

Sun H, Zhuang G, Chai L, Wang Z, Johnson D, Ma Y, Chen YH.

J Immunol. 2012 Sep 15;189(6):2768-73. doi: 10.4049/jimmunol.1103477. Epub 2012 Aug 17.


TIPE2, a negative regulator of TLR signaling, regulates p27 through IRF4-induced signaling.

Peng Y, Zhao Q, Zhang H, Han B, Liu S, Han M, Liu S.

Oncol Rep. 2016 Apr;35(4):2480-6. doi: 10.3892/or.2016.4562. Epub 2016 Jan 14.


Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation.

Yang CS, Lee JS, Rodgers M, Min CK, Lee JY, Kim HJ, Lee KH, Kim CJ, Oh B, Zandi E, Yue Z, Kramnik I, Liang C, Jung JU.

Cell Host Microbe. 2012 Mar 15;11(3):264-76. doi: 10.1016/j.chom.2012.01.018.


Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages.

Shen Y, Kawamura I, Nomura T, Tsuchiya K, Hara H, Dewamitta SR, Sakai S, Qu H, Daim S, Yamamoto T, Mitsuyama M.

Infect Immun. 2010 Jun;78(6):2857-67. doi: 10.1128/IAI.01138-09. Epub 2010 Apr 5.


Tissue-specific expression of TIPE2 provides insights into its function.

Zhang G, Hao C, Lou Y, Xi W, Wang X, Wang Y, Qu Z, Guo C, Chen Y, Zhang Y, Liu S.

Mol Immunol. 2010 Sep;47(15):2435-42. doi: 10.1016/j.molimm.2010.06.016. Epub 2010 Jul 21.


TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis.

Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J, Kong L, Xu L, Hilliard B, Hu S, Shen H, Yang X, Chen YH.

Cell. 2008 May 2;133(3):415-26. doi: 10.1016/j.cell.2008.03.026.


MAP1S Protein Regulates the Phagocytosis of Bacteria and Toll-like Receptor (TLR) Signaling.

Shi M, Zhang Y, Liu L, Zhang T, Han F, Cleveland J, Wang F, McKeehan WL, Li Y, Zhang D.

J Biol Chem. 2016 Jan 15;291(3):1243-50. doi: 10.1074/jbc.M115.687376. Epub 2015 Nov 12.


Innate immunity and arthritis: neutrophil Rac and toll-like receptor 4 expression define outcomes in infection-triggered arthritis.

Zhang X, Glogauer M, Zhu F, Kim TH, Chiu B, Inman RD.

Arthritis Rheum. 2005 Apr;52(4):1297-304.


Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2.

Fayngerts SA, Wang Z, Zamani A, Sun H, Boggs AE, Porturas TP, Xie W, Lin M, Cathopoulis T, Goldsmith JR, Vourekas A, Chen YH.

Nat Immunol. 2017 Dec;18(12):1353-1360. doi: 10.1038/ni.3866. Epub 2017 Oct 23.


Dissociation of recruitment and activation of the small G-protein Rac during Fcgamma receptor-mediated phagocytosis.

Cougoule C, Hoshino S, Dart A, Lim J, Caron E.

J Biol Chem. 2006 Mar 31;281(13):8756-64. Epub 2006 Jan 23.


MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2.

Ruan Q, Wang P, Wang T, Qi J, Wei M, Wang S, Fan T, Johnson D, Wan X, Shi W, Sun H, Chen YH.

Cell Death Dis. 2014 Feb 27;5:e1095. doi: 10.1038/cddis.2014.47.


TIPE2 deficiency accelerates neointima formation by downregulating smooth muscle cell differentiation.

Zhang G, Zhang W, Lou Y, Xi W, Cui J, Geng M, Zhu F, Chen YH, Liu S.

Cell Cycle. 2013 Feb 1;12(3):501-10. doi: 10.4161/cc.23325. Epub 2013 Jan 16.


TIPE2 protein prevents injury-induced restenosis in mice.

Zhang G, Zhao L, Wang Y, Shao J, Cui J, Lou Y, Geng M, Zhang N, Chen YH, Liu S.

Biochim Biophys Acta. 2015 Aug;1852(8):1574-84. doi: 10.1016/j.bbadis.2015.04.018. Epub 2015 Apr 22.


Enhanced atherosclerosis in TIPE2-deficient mice is associated with increased macrophage responses to oxidized low-density lipoprotein.

Lou Y, Liu S, Zhang C, Zhang G, Li J, Ni M, An G, Dong M, Liu X, Zhu F, Zhang W, Gao F, Chen YH, Zhang Y.

J Immunol. 2013 Nov 1;191(9):4849-57. doi: 10.4049/jimmunol.1300053. Epub 2013 Sep 30.


TIPE2 negatively regulates inflammation by switching arginine metabolism from nitric oxide synthase to arginase.

Lou Y, Zhang G, Geng M, Zhang W, Cui J, Liu S.

PLoS One. 2014 May 7;9(5):e96508. doi: 10.1371/journal.pone.0096508. eCollection 2014.


Differential requirement for classic and novel PKC isoforms in respiratory burst and phagocytosis in RAW 264.7 cells.

Larsen EC, DiGennaro JA, Saito N, Mehta S, Loegering DJ, Mazurkiewicz JE, Lennartz MR.

J Immunol. 2000 Sep 1;165(5):2809-17.


Expression of tumor necrosis factor-α induced protein 8 like-2 contributes to the immunosuppressive property of CD4(+)CD25(+) regulatory T cells in mice.

Luan YY, Yao YM, Zhang L, Dong N, Zhang QH, Yu Y, Sheng ZY.

Mol Immunol. 2011 Oct;49(1-2):219-26. doi: 10.1016/j.molimm.2011.08.016. Epub 2011 Oct 2.


The unique expression profile of human TIPE2 suggests new functions beyond its role in immune regulation.

Zhang L, Shi Y, Wang Y, Zhu F, Wang Q, Ma C, Chen YH, Zhang L.

Mol Immunol. 2011 May;48(9-10):1209-15. doi: 10.1016/j.molimm.2011.03.001. Epub 2011 Apr 3.


Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages.

Cho YJ, Cunnick JM, Yi SJ, Kaartinen V, Groffen J, Heisterkamp N.

Mol Cell Biol. 2007 Feb;27(3):899-911. Epub 2006 Nov 20.

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