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Fusion activation by a headless parainfluenza virus 5 hemagglutinin-neuraminidase stalk suggests a modular mechanism for triggering.

Bose S, Zokarkar A, Welch BD, Leser GP, Jardetzky TS, Lamb RA.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2625-34. Epub 2012 Sep 4.


Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells.

Bose S, Song AS, Jardetzky TS, Lamb RA.

J Virol. 2014 Apr;88(8):3925-41. doi: 10.1128/JVI.03741-13. Epub 2014 Jan 22.


Mutagenesis of Paramyxovirus Hemagglutinin-Neuraminidase Membrane-Proximal Stalk Region Influences Stability, Receptor Binding, and Neuraminidase Activity.

Adu-Gyamfi E, Kim LS, Jardetzky TS, Lamb RA.

J Virol. 2016 Aug 12;90(17):7778-88. doi: 10.1128/JVI.00896-16. Print 2016 Sep 1.


Structure and mutagenesis of the parainfluenza virus 5 hemagglutinin-neuraminidase stalk domain reveals a four-helix bundle and the role of the stalk in fusion promotion.

Bose S, Welch BD, Kors CA, Yuan P, Jardetzky TS, Lamb RA.

J Virol. 2011 Dec;85(24):12855-66. doi: 10.1128/JVI.06350-11. Epub 2011 Oct 12.


The Fusion Protein Specificity of the Parainfluenza Virus Hemagglutinin-Neuraminidase Protein Is Not Solely Defined by the Primary Structure of Its Stalk Domain.

Tsurudome M, Ito M, Ohtsuka J, Hara K, Komada H, Nishio M, Nosaka T.

J Virol. 2015 Dec;89(24):12374-87. doi: 10.1128/JVI.01448-15. Epub 2015 Sep 30.


The second receptor binding site of the globular head of the Newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion.

Porotto M, Salah Z, DeVito I, Talekar A, Palmer SG, Xu R, Wilson IA, Moscona A.

J Virol. 2012 May;86(10):5730-41. doi: 10.1128/JVI.06793-11. Epub 2012 Mar 21.


Flexibility of the Head-Stalk Linker Domain of Paramyxovirus HN Glycoprotein Is Essential for Triggering Virus Fusion.

Adu-Gyamfi E, Kim LS, Jardetzky TS, Lamb RA.

J Virol. 2016 Sep 29;90(20):9172-81. doi: 10.1128/JVI.01187-16. Print 2016 Oct 15.


Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) ectodomain.

Welch BD, Yuan P, Bose S, Kors CA, Lamb RA, Jardetzky TS.

PLoS Pathog. 2013;9(8):e1003534. doi: 10.1371/journal.ppat.1003534. Epub 2013 Aug 8.


Interaction between the hemagglutinin-neuraminidase and fusion glycoproteins of human parainfluenza virus type III regulates viral growth in vivo.

Xu R, Palmer SG, Porotto M, Palermo LM, Niewiesk S, Wilson IA, Moscona A.

MBio. 2013 Oct 22;4(5):e00803-13. doi: 10.1128/mBio.00803-13.


Roles of the highly conserved amino acids in the globular head and stalk region of the Newcastle disease virus HN protein in the membrane fusion process.

Sun C, Wen H, Chen Y, Chu F, Lin B, Ren G, Song Y, Wang Z.

Biosci Trends. 2015 Feb;9(1):56-64. doi: 10.5582/bst.2014.01140.


Measles virus fusion machinery activated by sialic acid binding globular domain.

Talekar A, Moscona A, Porotto M.

J Virol. 2013 Dec;87(24):13619-27. doi: 10.1128/JVI.02256-13. Epub 2013 Oct 9.


Mutations in the parainfluenza virus 5 fusion protein reveal domains important for fusion triggering and metastability.

Bose S, Heath CM, Shah PA, Alayyoubi M, Jardetzky TS, Lamb RA.

J Virol. 2013 Dec;87(24):13520-31. doi: 10.1128/JVI.02123-13. Epub 2013 Oct 2.


Adaptation of human parainfluenza virus to airway epithelium reveals fusion properties required for growth in host tissue.

Palmer SG, Porotto M, Palermo LM, Cunha LF, Greengard O, Moscona A.

MBio. 2012 Jun 5;3(3). pii: e00137-12. doi: 10.1128/mBio.00137-12. Print 2012.


Full conversion of the hemagglutinin-neuraminidase specificity of the parainfluenza virus 5 fusion protein by replacement of 21 amino acids in its head region with those of the simian virus 41 fusion protein.

Tsurudome M, Nakahashi M, Matsushima Y, Ito M, Nishio M, Kawano M, Komada H, Nosaka T.

J Virol. 2013 Aug;87(15):8342-50. doi: 10.1128/JVI.03549-12. Epub 2013 May 22.


Bimolecular complementation of paramyxovirus fusion and hemagglutinin-neuraminidase proteins enhances fusion: implications for the mechanism of fusion triggering.

Connolly SA, Leser GP, Jardetzky TS, Lamb RA.

J Virol. 2009 Nov;83(21):10857-68. doi: 10.1128/JVI.01191-09. Epub 2009 Aug 26.


Identification of regions on the hemagglutinin-neuraminidase protein of human parainfluenza virus type 2 important for promoting cell fusion.

Tsurudome M, Kawano M, Yuasa T, Tabata N, Nishio M, Komada H, Ito Y.

Virology. 1995 Oct 20;213(1):190-203.


Functional chimeric HN glycoproteins derived from Newcastle disease virus and human parainfluenza virus-3.

Deng R, Mirza AM, Mahon PJ, Iorio RM.

Arch Virol Suppl. 1997;13:115-30.


Roles of the fusion and hemagglutinin-neuraminidase proteins in replication, tropism, and pathogenicity of avian paramyxoviruses.

Kim SH, Subbiah M, Samuel AS, Collins PL, Samal SK.

J Virol. 2011 Sep;85(17):8582-96. doi: 10.1128/JVI.00652-11. Epub 2011 Jun 15.


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