Similar articles for PMID: 22949078

Year	Number of Results
2003	1
2005	1
2006	1
2007	1
2008	3
2009	4
2010	6
2011	3
2012	12
2013	6
2014	6
2015	9
2016	12
2017	8
2018	10
2019	7
2020	5
2021	5
2022	6
2024	0

1

Pathogenic mutation of ALK2 inhibits induced pluripotent stem cell reprogramming and maintenance: mechanisms of reprogramming and strategy for drug identification.

Hamasaki M, Hashizume Y, Yamada Y, Katayama T, Hohjoh H, Fusaki N, Nakashima Y, Furuya H, Haga N, Takami Y, Era T. Hamasaki M, et al. Stem Cells. 2012 Nov;30(11):2437-49. doi: 10.1002/stem.1221. Stem Cells. 2012. PMID: 22949078

2

ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation.

van Dinther M, Visser N, de Gorter DJ, Doorn J, Goumans MJ, de Boer J, ten Dijke P. van Dinther M, et al. J Bone Miner Res. 2010 Jun;25(6):1208-15. doi: 10.1359/jbmr.091110. J Bone Miner Res. 2010. PMID: 19929436 Free article.

3

Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva.

Cai J, Orlova VV, Cai X, Eekhoff EMW, Zhang K, Pei D, Pan G, Mummery CL, Ten Dijke P. Cai J, et al. Stem Cell Reports. 2015 Dec 8;5(6):963-970. doi: 10.1016/j.stemcr.2015.10.020. Epub 2015 Nov 26. Stem Cell Reports. 2015. PMID: 26626181 Free PMC article.

4

A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H.

Ohte S, Shin M, Sasanuma H, Yoneyama K, Akita M, Ikebuchi K, Jimi E, Maruki Y, Matsuoka M, Namba A, Tomoda H, Okazaki Y, Ohtake A, Oda H, Owan I, Yoda T, Furuya H, Kamizono J, Kitoh H, Nakashima Y, Susami T, Haga N, Komori T, Katagiri T. Ohte S, et al. Biochem Biophys Res Commun. 2011 Apr 1;407(1):213-8. doi: 10.1016/j.bbrc.2011.03.001. Epub 2011 Mar 4. Biochem Biophys Res Commun. 2011. PMID: 21377447

5

Concurrent progress of reprogramming and gene correction to overcome therapeutic limitation of mutant ALK2-iPSC.

Kim BY, Jeong S, Lee SY, Lee SM, Gweon EJ, Ahn H, Kim J, Chung SK. Kim BY, et al. Exp Mol Med. 2016 Jun 3;48(6):e237. doi: 10.1038/emm.2016.43. Exp Mol Med. 2016. PMID: 27256111 Free PMC article.

6

Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2.

Fujimoto M, Ohte S, Shin M, Yoneyama K, Osawa K, Miyamoto A, Tsukamoto S, Mizuta T, Kokabu S, Machiya A, Okuda A, Suda N, Katagiri T. Fujimoto M, et al. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):347-52. doi: 10.1016/j.bbrc.2014.11.012. Epub 2014 Nov 15. Biochem Biophys Res Commun. 2014. PMID: 25446088

7

AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation.

Lin H, Ying Y, Wang YY, Wang G, Jiang SS, Huang D, Luo L, Chen YG, Gerstenfeld LC, Luo Z. Lin H, et al. Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2369-2377. doi: 10.1016/j.bbamcr.2017.08.009. Epub 2017 Aug 25. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28847510 Free PMC article.

8

Disease-causing allele-specific silencing against the ALK2 mutants, R206H and G356D, in fibrodysplasia ossificans progressiva.

Takahashi M, Katagiri T, Furuya H, Hohjoh H. Takahashi M, et al. Gene Ther. 2012 Jul;19(7):781-5. doi: 10.1038/gt.2011.193. Epub 2011 Dec 1. Gene Ther. 2012. PMID: 22130450

9

A unique mutation of ALK2, G356D, found in a patient with fibrodysplasia ossificans progressiva is a moderately activated BMP type I receptor.

Fukuda T, Kanomata K, Nojima J, Kokabu S, Akita M, Ikebuchi K, Jimi E, Komori T, Maruki Y, Matsuoka M, Miyazono K, Nakayama K, Nanba A, Tomoda H, Okazaki Y, Ohtake A, Oda H, Owan I, Yoda T, Haga N, Furuya H, Katagiri T. Fukuda T, et al. Biochem Biophys Res Commun. 2008 Dec 19;377(3):905-9. doi: 10.1016/j.bbrc.2008.10.093. Epub 2008 Oct 24. Biochem Biophys Res Commun. 2008. PMID: 18952055

10

Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification.

Culbert AL, Chakkalakal SA, Theosmy EG, Brennan TA, Kaplan FS, Shore EM. Culbert AL, et al. Stem Cells. 2014 May;32(5):1289-300. doi: 10.1002/stem.1633. Stem Cells. 2014. PMID: 24449086 Free PMC article.

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