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The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer.

Kuner R, Fälth M, Pressinotti NC, Brase JC, Puig SB, Metzger J, Gade S, Schäfer G, Bartsch G, Steiner E, Klocker H, Sültmann H.

J Mol Med (Berl). 2013 Feb;91(2):237-48. doi: 10.1007/s00109-012-0949-1. Epub 2012 Sep 4.


Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers.

Gray D, Jubb AM, Hogue D, Dowd P, Kljavin N, Yi S, Bai W, Frantz G, Zhang Z, Koeppen H, de Sauvage FJ, Davis DP.

Cancer Res. 2005 Nov 1;65(21):9751-61.


Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.

Pickard MR, Green AR, Ellis IO, Caldas C, Hedge VL, Mourtada-Maarabouni M, Williams GT.

Breast Cancer Res. 2009;11(4):R60. doi: 10.1186/bcr2350. Epub 2009 Aug 11.


Maternal embryonic leucine zipper kinase (MELK): a novel regulator in cell cycle control, embryonic development, and cancer.

Jiang P, Zhang D.

Int J Mol Sci. 2013 Oct 31;14(11):21551-60. doi: 10.3390/ijms141121551. Review.


Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway.

Nakano I, Joshi K, Visnyei K, Hu B, Watanabe M, Lam D, Wexler E, Saigusa K, Nakamura Y, Laks DR, Mischel PS, Viapiano M, Kornblum HI.

Neuro Oncol. 2011 Jun;13(6):622-34. doi: 10.1093/neuonc/nor023. Epub 2011 May 9.


Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades.

Weichert W, Schmidt M, Gekeler V, Denkert C, Stephan C, Jung K, Loening S, Dietel M, Kristiansen G.

Prostate. 2004 Aug 1;60(3):240-5.


Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression.

Choi S, Ku JL.

Biochem Biophys Res Commun. 2011 Aug 26;412(2):207-13. doi: 10.1016/j.bbrc.2011.07.060. Epub 2011 Jul 22.


Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas.

Marie SK, Okamoto OK, Uno M, Hasegawa AP, Oba-Shinjo SM, Cohen T, Camargo AA, Kosoy A, Carlotti CG Jr, Toledo S, Moreira-Filho CA, Zago MA, Simpson AJ, Caballero OL.

Int J Cancer. 2008 Feb 15;122(4):807-15.


MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells.

Beke L, Kig C, Linders JT, Boens S, Boeckx A, van Heerde E, Parade M, De Bondt A, Van den Wyngaert I, Bashir T, Ogata S, Meerpoel L, Van Eynde A, Johnson CN, Beullens M, Brehmer D, Bollen M.

Biosci Rep. 2015 Oct 2;35(6). pii: e00267. doi: 10.1042/BSR20150194.


Heat shock protein expression independently predicts clinical outcome in prostate cancer.

Cornford PA, Dodson AR, Parsons KF, Desmond AD, Woolfenden A, Fordham M, Neoptolemos JP, Ke Y, Foster CS.

Cancer Res. 2000 Dec 15;60(24):7099-105.


Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells.

Weiss-Messer E, Merom O, Adi A, Karry R, Bidosee M, Ber R, Kaploun A, Stein A, Barkey RJ.

Mol Cell Endocrinol. 2004 May 31;220(1-2):109-23.


Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit.

Badouel C, Chartrain I, Blot J, Tassan JP.

Exp Cell Res. 2010 Aug 1;316(13):2166-73. doi: 10.1016/j.yexcr.2010.04.019. Epub 2010 Apr 24.


Comprehensive gene expression microarray analysis of Ets-1 blockade in PC3 prostate cancer cells and correlations with prostate cancer tissues: Insights into genes involved in the metastatic cascade.

Shaikhibrahim Z, Lindstrot A, Langer B, Buettner R, Wernert N.

Int J Mol Med. 2011 Jun;27(6):811-9. doi: 10.3892/ijmm.2011.652. Epub 2011 Mar 21.


Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2.

Chen J, Deng F, Singh SV, Wang QJ.

Cancer Res. 2008 May 15;68(10):3844-53. doi: 10.1158/0008-5472.CAN-07-5156.


Structural insight into maternal embryonic leucine zipper kinase (MELK) conformation and inhibition toward structure-based drug design.

Canevari G, Re Depaolini S, Cucchi U, Bertrand JA, Casale E, Perrera C, Forte B, Carpinelli P, Felder ER.

Biochemistry. 2013 Sep 17;52(37):6380-7. doi: 10.1021/bi4005864. Epub 2013 Sep 4.


Epigenetics-related genes in prostate cancer: expression profile in prostate cancer tissues, androgen-sensitive and -insensitive cell lines.

Shaikhibrahim Z, Lindstrot A, Ochsenfahrt J, Fuchs K, Wernert N.

Int J Mol Med. 2013 Jan;31(1):21-5. doi: 10.3892/ijmm.2012.1173. Epub 2012 Nov 6.


Fibroblast growth factor 17 is over-expressed in human prostate cancer.

Heer R, Douglas D, Mathers ME, Robson CN, Leung HY.

J Pathol. 2004 Dec;204(5):578-86.


Overexpression of high mobility group box 1 with poor prognosis in patients after radical prostatectomy.

Li T, Gui Y, Yuan T, Liao G, Bian C, Jiang Q, Huang S, Liu B, Wu D.

BJU Int. 2012 Dec;110(11 Pt C):E1125-30. doi: 10.1111/j.1464-410X.2012.11277.x. Epub 2012 Jun 6.


High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence.

Ayala G, Thompson T, Yang G, Frolov A, Li R, Scardino P, Ohori M, Wheeler T, Harper W.

Clin Cancer Res. 2004 Oct 1;10(19):6572-8. Erratum in: Clin Cancer Res. 2005 Jul 15;11(14):5330.

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