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Items: 1 to 20 of 103

1.

Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus.

Koga T, Ichinose K, Mizui M, Crispín JC, Tsokos GC.

J Immunol. 2012 Oct 1;189(7):3490-6. Epub 2012 Aug 31.

2.

KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice.

Koga T, Mizui M, Yoshida N, Otomo K, Lieberman LA, Crispín JC, Tsokos GC.

Autoimmunity. 2014 Nov;47(7):445-50. doi: 10.3109/08916934.2014.915954. Epub 2014 May 15.

3.

Jieduquyuziyin prescription suppresses IL-17 production and Th17 activity in MRL/lpr mice by inhibiting expression of Ca(2+)/calmodulin-dependent protein kinase-4.

Shui B, Xia W, Wen C, Ding X.

J Nat Med. 2015 Jul;69(3):349-57. doi: 10.1007/s11418-015-0900-1. Epub 2015 Mar 28.

PMID:
25821132
4.

Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV.

Ichinose K, Juang YT, Crispín JC, Kis-Toth K, Tsokos GC.

Arthritis Rheum. 2011 Feb;63(2):523-9. doi: 10.1002/art.30085.

5.

Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.

Ichinose K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri SY, Iwamoto N, Tamai M, Arima K, Nakamura H, Obata Y, Yamamoto K, Origuchi T, Nishino T, Kawakami A, Tsokos GC.

Arthritis Rheumatol. 2016 Apr;68(4):944-52. doi: 10.1002/art.39499.

6.

CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance.

Koga T, Hedrich CM, Mizui M, Yoshida N, Otomo K, Lieberman LA, Rauen T, Crispín JC, Tsokos GC.

J Clin Invest. 2014 May;124(5):2234-45. doi: 10.1172/JCI73411. Epub 2014 Mar 25.

7.

Exacerbation of lupus nephritis by high sodium chloride related to activation of SGK1 pathway.

Yang X, Yao G, Chen W, Tang X, Feng X, Sun L.

Int Immunopharmacol. 2015 Dec;29(2):568-73. doi: 10.1016/j.intimp.2015.09.027. Epub 2015 Oct 23.

PMID:
26474695
8.

Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-Fas lpr mice.

Fujita Y, Fujii T, Mimori T, Sato T, Nakamura T, Iwao H, Nakajima A, Miki M, Sakai T, Kawanami T, Tanaka M, Masaki Y, Fukushima T, Okazaki T, Umehara H.

J Immunol. 2014 Feb 1;192(3):979-84. doi: 10.4049/jimmunol.1301685. Epub 2014 Jan 3.

9.

CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis.

Steinmetz OM, Turner JE, Paust HJ, Lindner M, Peters A, Heiss K, Velden J, Hopfer H, Fehr S, Krieger T, Meyer-Schwesinger C, Meyer TN, Helmchen U, Mittrücker HW, Stahl RA, Panzer U.

J Immunol. 2009 Oct 1;183(7):4693-704. doi: 10.4049/jimmunol.0802626. Epub 2009 Sep 4.

10.

Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus.

Cash H, Relle M, Menke J, Brochhausen C, Jones SA, Topley N, Galle PR, Schwarting A.

J Rheumatol. 2010 Jan;37(1):60-70. doi: 10.3899/jrheum.090194. Epub 2009 Dec 1.

PMID:
19955044
11.

Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis.

Ichinose K, Rauen T, Juang YT, Kis-Toth K, Mizui M, Koga T, Tsokos GC.

J Immunol. 2011 Dec 1;187(11):5500-4. doi: 10.4049/jimmunol.1102357. Epub 2011 Oct 26.

12.

Function of the Th17/interleukin-17A immune response in murine lupus nephritis.

Schmidt T, Paust HJ, Krebs CF, Turner JE, Kaffke A, Bennstein SB, Koyro T, Peters A, Velden J, Hünemörder S, Haag F, Steinmetz OM, Mittrücker HW, Stahl RA, Panzer U.

Arthritis Rheumatol. 2015 Feb;67(2):475-87. doi: 10.1002/art.38955.

13.

IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells.

Mizui M, Koga T, Lieberman LA, Beltran J, Yoshida N, Johnson MC, Tisch R, Tsokos GC.

J Immunol. 2014 Sep 1;193(5):2168-77. doi: 10.4049/jimmunol.1400977. Epub 2014 Jul 25.

14.

Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice.

Otomo K, Koga T, Mizui M, Yoshida N, Kriegel C, Bickerton S, Fahmy TM, Tsokos GC.

J Immunol. 2015 Dec 15;195(12):5533-7. doi: 10.4049/jimmunol.1501603. Epub 2015 Nov 11.

15.

Activated protein C attenuates systemic lupus erythematosus and lupus nephritis in MRL-Fas(lpr) mice.

Lichtnekert J, Rupanagudi KV, Kulkarni OP, Darisipudi MN, Allam R, Anders HJ.

J Immunol. 2011 Sep 15;187(6):3413-21. doi: 10.4049/jimmunol.1101125. Epub 2011 Aug 17.

16.

Effect of nonmyeloablative unrelated fetal and neonatal murine peripheral blood mononuclear cell infusion on MRL/lpr mice.

Chuan W, Wu-qing W, Zhu-wen Y, Zuo L.

Lupus. 2014 Sep;23(10):994-1005. doi: 10.1177/0961203314532561. Epub 2014 Apr 22.

PMID:
24756437
17.
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19.

Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus.

Lech M, Kantner C, Kulkarni OP, Ryu M, Vlasova E, Heesemann J, Anz D, Endres S, Kobayashi KS, Flavell RA, Martin J, Anders HJ.

Ann Rheum Dis. 2011 Dec;70(12):2207-17. doi: 10.1136/ard.2011.155515. Epub 2011 Aug 29.

PMID:
21875872
20.

Piperlongumine alleviates lupus nephritis in MRL-Fas(lpr) mice by regulating the frequency of Th17 and regulatory T cells.

Yao L, Chen HP, Ma Q.

Immunol Lett. 2014 Sep;161(1):76-80. doi: 10.1016/j.imlet.2014.05.001. Epub 2014 May 14.

PMID:
24837470

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