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Items: 1 to 20 of 463

1.

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.

Colombo A, Wang H, Kuhn PH, Page R, Kremmer E, Dempsey PJ, Crawford HC, Lichtenthaler SF.

Neurobiol Dis. 2013 Jan;49:137-47. doi: 10.1016/j.nbd.2012.08.011. Epub 2012 Aug 24.

2.

Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.

Hogl S, Kuhn PH, Colombo A, Lichtenthaler SF.

PLoS One. 2011;6(6):e21337. doi: 10.1371/journal.pone.0021337. Epub 2011 Jun 17.

3.

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.

Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Rossner S, Lichtenthaler SF.

EMBO J. 2010 Sep 1;29(17):3020-32. doi: 10.1038/emboj.2010.167. Epub 2010 Jul 30.

4.

Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells.

Panmanee J, Nopparat C, Chavanich N, Shukla M, Mukda S, Song W, Vincent B, Govitrapong P.

J Pineal Res. 2015 Oct;59(3):308-20. doi: 10.1111/jpi.12260. Epub 2015 Jul 18.

PMID:
26123100
5.

η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C.

Nature. 2015 Oct 15;526(7573):443-7. doi: 10.1038/nature14864. Epub 2015 Aug 31.

PMID:
26322584
6.

Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP.

Corbett GT, Gonzalez FJ, Pahan K.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8445-50. doi: 10.1073/pnas.1504890112. Epub 2015 Jun 15.

7.

Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein.

Mamada N, Tanokashira D, Ishii K, Tamaoka A, Araki W.

Biochem Biophys Res Commun. 2017 Apr 29;486(2):321-328. doi: 10.1016/j.bbrc.2017.03.035. Epub 2017 Mar 14.

PMID:
28302486
8.

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.

Eur J Neurosci. 2013 Jun;37(12):1962-9. doi: 10.1111/ejn.12235.

PMID:
23773065
9.

Effects of Folic Acid on Secretases Involved in Aβ Deposition in APP/PS1 Mice.

Tian T, Bai D, Li W, Huang GW, Liu H.

Nutrients. 2016 Sep 9;8(9). pii: E556. doi: 10.3390/nu8090556.

10.

Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.

Harris B, Pereira I, Parkin E.

Brain Res. 2009 Nov 3;1296:203-15. doi: 10.1016/j.brainres.2009.07.105. Epub 2009 Aug 11.

PMID:
19679113
11.
12.

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.

J Pharmacol Exp Ther. 2008 Mar;324(3):957-69. Epub 2007 Dec 21.

13.

Auraptene increases the production of amyloid-β via c-Jun N-terminal kinase-dependent activation of γ-secretase.

Jung CG, Uhm KO, Horike H, Kim MJ, Misumi S, Ishida A, Ueda Y, Choi EK, Kim YS, Michikawa M, Hida H.

J Alzheimers Dis. 2015;43(4):1215-28. doi: 10.3233/JAD-141692.

PMID:
25147119
14.

Cryptotanshinione upregulates alpha-secretase by activation PI3K pathway in cortical neurons.

Mei Z, Situ B, Tan X, Zheng S, Zhang F, Yan P, Liu P.

Brain Res. 2010 Aug 12;1348:165-73. doi: 10.1016/j.brainres.2010.05.083. Epub 2010 Jun 2.

PMID:
20595051
15.

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

Buggia-Prevot V, Sevalle J, Rossner S, Checler F.

J Biol Chem. 2008 Apr 11;283(15):10037-47. doi: 10.1074/jbc.M706579200. Epub 2008 Feb 8.

16.

C6 Glioma-Secreted NGF and FGF2 Regulate Neuronal APP Processing Through Up-Regulation of ADAM10 and Down-Regulation of BACE1, Respectively.

Xie H, Xiao Z, Huang J.

J Mol Neurosci. 2016 Jul;59(3):334-42. doi: 10.1007/s12031-015-0690-7. Epub 2015 Nov 27.

PMID:
26614345
17.

CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase.

Singh AK, Pati U.

Aging Cell. 2015 Aug;14(4):595-604. doi: 10.1111/acel.12335. Epub 2015 Mar 13.

18.

The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein.

Delarasse C, Auger R, Gonnord P, Fontaine B, Kanellopoulos JM.

J Biol Chem. 2011 Jan 28;286(4):2596-606. doi: 10.1074/jbc.M110.200618. Epub 2010 Nov 16.

19.

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.

Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3922-7.

20.

Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production.

Tian Y, Crump CJ, Li YM.

J Biol Chem. 2010 Oct 15;285(42):32549-56. doi: 10.1074/jbc.M110.128439. Epub 2010 Jul 30.

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