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Items: 1 to 20 of 102

1.

New insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin I.

Henze M, Patrick SE, Hinken A, Scruggs SB, Goldspink P, de Tombe PP, Kobayashi M, Ping P, Kobayashi T, Solaro RJ.

Biochim Biophys Acta. 2013 Apr;1833(4):823-32. doi: 10.1016/j.bbamcr.2012.08.012.

PMID:
22940544
2.

Phosphorylation of cardiac troponin I at protein kinase C site threonine 144 depresses cooperative activation of thin filaments.

Lu QW, Hinken AC, Patrick SE, Solaro RJ, Kobayashi T.

J Biol Chem. 2010 Apr 16;285(16):11810-7. doi: 10.1074/jbc.M109.055657.

PMID:
20164197
3.

N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle.

Rao VS, Korte FS, Razumova MV, Feest ER, Hsu H, Irving TC, Regnier M, Martyn DA.

J Physiol. 2013 Jan 15;591(2):475-90. doi: 10.1113/jphysiol.2012.241604.

PMID:
23129792
4.

Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium.

Pi Y, Zhang D, Kemnitz KR, Wang H, Walker JW.

J Physiol. 2003 Nov 1;552(Pt 3):845-57.

PMID:
12923217
5.

Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.

Wijnker PJ, Sequeira V, Witjas-Paalberends ER, Foster DB, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J.

Arch Biochem Biophys. 2014 Jul 15;554:11-21. doi: 10.1016/j.abb.2014.04.017.

PMID:
24814372
6.
7.

Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity.

Parvatiyar MS, Pinto JR.

Biochim Biophys Acta. 2015 Feb;1850(2):365-72. doi: 10.1016/j.bbagen.2014.09.029.

PMID:
25450489
8.

Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy.

Wang Y, Pinto JR, Solis RS, Dweck D, Liang J, Diaz-Perez Z, Ge Y, Walker JW, Potter JD.

J Biol Chem. 2012 Jan 13;287(3):2156-67. doi: 10.1074/jbc.M111.294306.

PMID:
22086914
9.

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy.

Takahashi-Yanaga F, Morimoto S, Harada K, Minakami R, Shiraishi F, Ohta M, Lu QW, Sasaguri T, Ohtsuki I.

J Mol Cell Cardiol. 2001 Dec;33(12):2095-107.

PMID:
11735257
10.

Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function.

Haworth RS, Cuello F, Herron TJ, Franzen G, Kentish JC, Gautel M, Avkiran M.

Circ Res. 2004 Nov 26;95(11):1091-9.

PMID:
15514163
11.

Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling.

Bardswell SC, Cuello F, Rowland AJ, Sadayappan S, Robbins J, Gautel M, Walker JW, Kentish JC, Avkiran M.

J Biol Chem. 2010 Feb 19;285(8):5674-82. doi: 10.1074/jbc.M109.066456.

PMID:
20018870
12.

Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.

Cheng Y, Rao V, Tu AY, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M.

J Biol Chem. 2015 Nov 13;290(46):27749-66. doi: 10.1074/jbc.M115.683045.

PMID:
26391394
13.

Localization of regions of troponin I important in deactivation of cardiac myofilaments by acidic pH.

Li G, Martin AF, Solaro RJ.

J Mol Cell Cardiol. 2001 Jul;33(7):1309-20.

PMID:
11437537
14.

The unique amino-terminal peptide of cardiac troponin I regulates myofibrillar activity only when it is phosphorylated.

Wattanapermpool J, Guo X, Solaro RJ.

J Mol Cell Cardiol. 1995 Jul;27(7):1383-91.

PMID:
7473784
15.

Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics.

Cheng Y, Lindert S, Kekenes-Huskey P, Rao VS, Solaro RJ, Rosevear PR, Amaro R, McCulloch AD, McCammon JA, Regnier M.

Biophys J. 2014 Oct 7;107(7):1675-85. doi: 10.1016/j.bpj.2014.08.008.

PMID:
25296321
16.

Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity.

Memo M, Leung MC, Ward DG, dos Remedios C, Morimoto S, Zhang L, Ravenscroft G, McNamara E, Nowak KJ, Marston SB, Messer AE.

Cardiovasc Res. 2013 Jul 1;99(1):65-73. doi: 10.1093/cvr/cvt071.

PMID:
23539503
17.

Increased cross-bridge cycling kinetics after exchange of C-terminal truncated troponin I in skinned rat cardiac muscle.

Tachampa K, Kobayashi T, Wang H, Martin AF, Biesiadecki BJ, Solaro RJ, de Tombe PP.

J Biol Chem. 2008 May 30;283(22):15114-21. doi: 10.1074/jbc.M801636200.

PMID:
18378675
18.

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis.

Wijnker PJ, Li Y, Zhang P, Foster DB, dos Remedios C, Van Eyk JE, Stienen GJ, Murphy AM, van der Velden J.

J Mol Cell Cardiol. 2015 May;82:93-103. doi: 10.1016/j.yjmcc.2015.03.006.

PMID:
25771144
19.

Phosphorylation of human cardiac troponin I G203S and K206Q linked to familial hypertrophic cardiomyopathy affects actomyosin interaction in different ways.

Deng Y, Schmidtmann A, Kruse S, Filatov V, Heilmeyer LM Jr, Jaquet K, Thieleczek R.

J Mol Cell Cardiol. 2003 Nov;35(11):1365-74.

PMID:
14596793
20.

The C terminus of cardiac troponin I is essential for full inhibitory activity and Ca2+ sensitivity of rat myofibrils.

Rarick HM, Tu XH, Solaro RJ, Martin AF.

J Biol Chem. 1997 Oct 24;272(43):26887-92.

PMID:
9341121
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