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Items: 1 to 20 of 102


Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses.

Dong N, Zhu Y, Lu Q, Hu L, Zheng Y, Shao F.

Cell. 2012 Aug 31;150(5):1029-41. doi: 10.1016/j.cell.2012.06.050.


Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP.

Yu Q, Hu L, Yao Q, Zhu Y, Dong N, Wang DC, Shao F.

Cell Res. 2013 Jun;23(6):775-87. doi: 10.1038/cr.2013.54. Epub 2013 Apr 16.


The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

Newton HJ, Pearson JS, Badea L, Kelly M, Lucas M, Holloway G, Wagstaff KM, Dunstone MA, Sloan J, Whisstock JC, Kaper JB, Robins-Browne RM, Jans DA, Frankel G, Phillips AD, Coulson BS, Hartland EL.

PLoS Pathog. 2010 May 13;6(5):e1000898. doi: 10.1371/journal.ppat.1000898.


EspG, a novel type III system-secreted protein from enteropathogenic Escherichia coli with similarities to VirA of Shigella flexneri.

Elliott SJ, Krejany EO, Mellies JL, Robins-Browne RM, Sasakawa C, Kaper JB.

Infect Immun. 2001 Jun;69(6):4027-33.


Structural and functional studies indicate that the EPEC effector, EspG, directly binds p21-activated kinase.

Germane KL, Spiller BW.

Biochemistry. 2011 Feb 15;50(6):917-9. doi: 10.1021/bi1020138. Epub 2011 Jan 24.


The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.

Selyunin AS, Sutton SE, Weigele BA, Reddick LE, Orchard RC, Bresson SM, Tomchick DR, Alto NM.

Nature. 2011 Jan 6;469(7328):107-11. doi: 10.1038/nature09593. Epub 2010 Dec 19.


Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA.

Campbell-Valois FX, Sachse M, Sansonetti PJ, Parsot C.

MBio. 2015 May 26;6(3):e02567-14. doi: 10.1128/mBio.02567-14.


Structural and functional studies indicate that Shigella VirA is not a protease and does not directly destabilize microtubules.

Germane KL, Ohi R, Goldberg MB, Spiller BW.

Biochemistry. 2008 Sep 30;47(39):10241-3. doi: 10.1021/bi801533k. Epub 2008 Sep 3.


Shigella flexneri regulation of ARF6 activation during bacterial entry via an IpgD-mediated positive feedback loop.

Garza-Mayers AC, Miller KA, Russo BC, Nagda DV, Goldberg MB.

MBio. 2015 Mar 3;6(2):e02584. doi: 10.1128/mBio.02584-14.


Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri.

Davis J, Wang J, Tropea JE, Zhang D, Dauter Z, Waugh DS, Wlodawer A.

Protein Sci. 2008 Dec;17(12):2167-73. doi: 10.1110/ps.037978.108. Epub 2008 Sep 11.


Modulation of host cytoskeleton function by the enteropathogenic Escherichia coli and Citrobacter rodentium effector protein EspG.

Hardwidge PR, Deng W, Vallance BA, Rodriguez-Escudero I, Cid VJ, Molina M, Finlay BB.

Infect Immun. 2005 May;73(5):2586-94.


TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.

Pan X, Eathiraj S, Munson M, Lambright DG.

Nature. 2006 Jul 20;442(7100):303-6.


TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.

Sklan EH, Serrano RL, Einav S, Pfeffer SR, Lambright DG, Glenn JS.

J Biol Chem. 2007 Dec 14;282(50):36354-61. Epub 2007 Sep 27.


EspG of enteropathogenic and enterohemorrhagic E. coli binds the Golgi matrix protein GM130 and disrupts the Golgi structure and function.

Clements A, Smollett K, Lee SF, Hartland EL, Lowe M, Frankel G.

Cell Microbiol. 2011 Sep;13(9):1429-39. doi: 10.1111/j.1462-5822.2011.01631.x. Epub 2011 Jul 11.


The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism.

Ismail SA, Vetter IR, Sot B, Wittinghofer A.

Cell. 2010 May 28;141(5):812-21. doi: 10.1016/j.cell.2010.03.051. Erratum in: Cell. 2010 Dec 23;143(7):1190.


Identification of a Distinct Substrate-binding Domain in the Bacterial Cysteine Methyltransferase Effectors NleE and OspZ.

Zhang Y, Mühlen S, Oates CV, Pearson JS, Hartland EL.

J Biol Chem. 2016 Sep 16;291(38):20149-62. doi: 10.1074/jbc.M116.734079. Epub 2016 Jul 21.


Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ.

Burnaevskiy N, Fox TG, Plymire DA, Ertelt JM, Weigele BA, Selyunin AS, Way SS, Patrie SM, Alto NM.

Nature. 2013 Apr 4;496(7443):106-9. doi: 10.1038/nature12004. Epub 2013 Mar 27.


Characterization of two homologous disulfide bond systems involved in virulence factor biogenesis in uropathogenic Escherichia coli CFT073.

Totsika M, Heras B, Wurpel DJ, Schembri MA.

J Bacteriol. 2009 Jun;191(12):3901-8. doi: 10.1128/JB.00143-09. Epub 2009 Apr 17.


The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism.

Mishra AK, Del Campo CM, Collins RE, Roy CR, Lambright DG.

J Biol Chem. 2013 Aug 16;288(33):24000-11. doi: 10.1074/jbc.M113.470625. Epub 2013 Jul 2.

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