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Items: 1 to 20 of 177

1.

Single-stranded siRNAs activate RNAi in animals.

Lima WF, Prakash TP, Murray HM, Kinberger GA, Li W, Chappell AE, Li CS, Murray SF, Gaus H, Seth PP, Swayze EE, Crooke ST.

Cell. 2012 Aug 31;150(5):883-94. doi: 10.1016/j.cell.2012.08.014.

2.

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes.

Matranga C, Tomari Y, Shin C, Bartel DP, Zamore PD.

Cell. 2005 Nov 18;123(4):607-20. Epub 2005 Nov 3.

3.

5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, Manoharan M, Meyers R, Maier MA, Jadhav V.

Chembiochem. 2016 Jun 2;17(11):985-9. doi: 10.1002/cbic.201600130. Epub 2016 Apr 28.

PMID:
27121751
4.

Competition potency of siRNA is specified by the 5'-half sequence of the guide strand.

Yoo JW, Kim S, Lee DK.

Biochem Biophys Res Commun. 2008 Feb 29;367(1):78-83. doi: 10.1016/j.bbrc.2007.12.099. Epub 2007 Dec 27.

PMID:
18164261
5.

Identification of metabolically stable 5'-phosphate analogs that support single-stranded siRNA activity.

Prakash TP, Lima WF, Murray HM, Li W, Kinberger GA, Chappell AE, Gaus H, Seth PP, Bhat B, Crooke ST, Swayze EE.

Nucleic Acids Res. 2015 Mar 31;43(6):2993-3011. doi: 10.1093/nar/gkv162. Epub 2015 Mar 9.

6.

5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.

Haraszti RA, Roux L, Coles AH, Turanov AA, Alterman JF, Echeverria D, Godinho BMDC, Aronin N, Khvorova A.

Nucleic Acids Res. 2017 Jul 27;45(13):7581-7592. doi: 10.1093/nar/gkx507.

7.

siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L.

Nucleic Acids Res. 2017 Apr 7;45(6):3528-3536. doi: 10.1093/nar/gkw1171.

8.

Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing.

Bartlett DW, Davis ME.

Biotechnol Bioeng. 2007 Jul 1;97(4):909-21.

PMID:
17154307
9.

Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection.

Sano M, Sierant M, Miyagishi M, Nakanishi M, Takagi Y, Sutou S.

Nucleic Acids Res. 2008 Oct;36(18):5812-21. doi: 10.1093/nar/gkn584. Epub 2008 Sep 9.

10.

The design, preparation, and evaluation of asymmetric small interfering RNA for specific gene silencing in mammalian cells.

Chang C, Hong SW, Dua P, Kim S, Lee DK.

Methods Mol Biol. 2013;942:135-52. doi: 10.1007/978-1-62703-119-6_7.

PMID:
23027049
11.

Potent RNAi by short RNA triggers.

Chu CY, Rana TM.

RNA. 2008 Sep;14(9):1714-9. doi: 10.1261/rna.1161908. Epub 2008 Jul 24.

12.

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.

Martinez J, Patkaniowska A, Urlaub H, Lührmann R, Tuschl T.

Cell. 2002 Sep 6;110(5):563-74.

13.

SiRNAs conjugated with aromatic compounds induce RISC-mediated antisense strand selection and strong gene-silencing activity.

Kubo T, Yanagihara K, Takei Y, Mihara K, Sato Y, Seyama T.

Biochem Biophys Res Commun. 2012 Oct 5;426(4):571-7. doi: 10.1016/j.bbrc.2012.08.128. Epub 2012 Sep 7.

PMID:
22982308
14.

Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes.

Kim K, Lee YS, Carthew RW.

RNA. 2007 Jan;13(1):22-9. Epub 2006 Nov 22.

15.

Evaluation of siRNAs that contain internal variable-length spacer linkages.

Efthymiou TC, Peel B, Huynh V, Desaulniers JP.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5590-4. doi: 10.1016/j.bmcl.2012.07.006. Epub 2012 Jul 16.

PMID:
22850216
16.

The 5' binding MID domain of human Argonaute2 tolerates chemically modified nucleotide analogues.

Deleavey GF, Frank F, Hassler M, Wisnovsky S, Nagar B, Damha MJ.

Nucleic Acid Ther. 2013 Feb;23(1):81-7. doi: 10.1089/nat.2012.0393. Epub 2013 Jan 5.

PMID:
23289589
17.

RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells.

Hoshika S, Minakawa N, Kamiya H, Harashima H, Matsuda A.

FEBS Lett. 2005 Jun 6;579(14):3115-8.

18.

The Argonautes.

Joshua-Tor L.

Cold Spring Harb Symp Quant Biol. 2006;71:67-72. Review.

PMID:
17381282
19.

The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC.

Horwich MD, Li C, Matranga C, Vagin V, Farley G, Wang P, Zamore PD.

Curr Biol. 2007 Jul 17;17(14):1265-72. Epub 2007 Jun 28.

20.

Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties.

Wee LM, Flores-Jasso CF, Salomon WE, Zamore PD.

Cell. 2012 Nov 21;151(5):1055-67. doi: 10.1016/j.cell.2012.10.036. Erratum in: Cell. 2013 Jan 17;152(1-2):366.

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