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Items: 1 to 20 of 117

1.

Proteinase 3 activity in sputum from subjects with alpha-1-antitrypsin deficiency and COPD.

Sinden NJ, Stockley RA.

Eur Respir J. 2013 May;41(5):1042-50. doi: 10.1183/09031936.00089712. Epub 2012 Aug 30.

2.

Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD.

Ungurs MJ, Sinden NJ, Stockley RA.

Am J Physiol Lung Cell Mol Physiol. 2014 Jan 1;306(1):L80-7. doi: 10.1152/ajplung.00221.2013. Epub 2013 Nov 1.

PMID:
24186875
3.

Proteinase 3, a potent secretagogue in airways, is present in cystic fibrosis sputum.

Witko-Sarsat V, Halbwachs-Mecarelli L, Schuster A, Nusbaum P, Ueki I, Canteloup S, Lenoir G, Descamps-Latscha B, Nadel JA.

Am J Respir Cell Mol Biol. 1999 Apr;20(4):729-36.

PMID:
10101005
4.
5.

The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo.

Carter RI, Mumford RA, Treonze KM, Finke PE, Davies P, Si Q, Humes JL, Dirksen A, Piitulainen E, Ahmad A, Stockley RA.

Thorax. 2011 Aug;66(8):686-91. doi: 10.1136/thx.2010.154690. Epub 2011 May 26.

PMID:
21617168
6.

Variability of sputum inflammatory mediators in COPD and α1-antitrypsin deficiency.

Stone H, McNab G, Wood AM, Stockley RA, Sapey E.

Eur Respir J. 2012 Sep;40(3):561-9. doi: 10.1183/09031936.00162811. Epub 2012 Jun 14.

8.

The interrelationship of sputum inflammatory markers in patients with chronic bronchitis.

Hill AT, Bayley D, Stockley RA.

Am J Respir Crit Care Med. 1999 Sep;160(3):893-8.

PMID:
10471615
10.

Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.

Geraghty P, Rogan MP, Greene CM, Brantly ML, O'Neill SJ, Taggart CC, McElvaney NG.

Thorax. 2008 Jul;63(7):621-6. doi: 10.1136/thx.2007.088559. Epub 2008 Feb 4.

PMID:
18250185
11.

Elevated soluble HLA II protein levels in patients with alpha-1 antitrypsin deficiency with or without COPD.

Li L, Kueppers F, Hildebrand W, Buchli R, Gaughan J.

Exp Lung Res. 2012 Aug;38(6):302-6. doi: 10.3109/01902148.2012.691944. Epub 2012 Jun 11.

PMID:
22686467
12.

Transient elevation of neutrophil proteinases in induced sputum during COPD exacerbation.

Ilumets H, Rytilä PH, Sovijärvi AR, Tervahartiala T, Myllärniemi M, Sorsa TA, Kinnula VL.

Scand J Clin Lab Invest. 2008;68(7):618-23. doi: 10.1080/00365510801983773.

PMID:
19378434
13.

Airways inflammation in chronic bronchitis: the effects of smoking and alpha1-antitrypsin deficiency.

Hill AT, Bayley DL, Campbell EJ, Hill SL, Stockley RA.

Eur Respir J. 2000 May;15(5):886-90.

14.
15.

α-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease.

Sinden NJ, Baker MJ, Smith DJ, Kreft JU, Dafforn TR, Stockley RA.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L179-90.

16.

Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis.

Hill AT, Campbell EJ, Hill SL, Bayley DL, Stockley RA.

Am J Med. 2000 Sep;109(4):288-95.

PMID:
10996579
17.

Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency.

Gompertz S, Hill AT, Bayley DL, Stockley RA.

Respir Med. 2006 Jun;100(6):1094-9. Epub 2005 Oct 27.

18.

A selective reversible azapeptide inhibitor of human neutrophil proteinase 3 derived from a high affinity FRET substrate.

Epinette C, Croix C, Jaquillard L, Marchand-Adam S, Kellenberger C, Lalmanach G, Cadene M, Viaud-Massuard MC, Gauthier F, Korkmaz B.

Biochem Pharmacol. 2012 Mar 15;83(6):788-96. doi: 10.1016/j.bcp.2011.12.023. Epub 2011 Dec 24.

PMID:
22209715
19.

Glucocorticosteroids differentially regulate MMP-9 and neutrophil elastase in COPD.

Vlahos R, Wark PA, Anderson GP, Bozinovski S.

PLoS One. 2012;7(3):e33277. doi: 10.1371/journal.pone.0033277. Epub 2012 Mar 7.

20.

Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and BAL in COPD.

Lapperre TS, Willems LN, Timens W, Rabe KF, Hiemstra PS, Postma DS, Sterk PJ.

Chest. 2007 Jan;131(1):53-9.

PMID:
17218556

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