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Items: 1 to 20 of 158

1.

Discovery of novel scaffolds for Rho kinase 2 inhibitor through TRFRET-based high throughput screening assay.

Oh KS, Mun J, Cho JE, Lee S, Yi KY, Lim CJ, Lee JS, Park WJ, Lee BH.

Comb Chem High Throughput Screen. 2013 Jan;16(1):37-46.

PMID:
22934984
2.

Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II).

Schröter T, Minond D, Weiser A, Dao C, Habel J, Spicer T, Chase P, Baillargeon P, Scampavia L, Schürer S, Chung C, Mader C, Southern M, Tsinoremas N, LoGrasso P, Hodder P.

J Biomol Screen. 2008 Jan;13(1):17-28. doi: 10.1177/1087057107310806.

PMID:
18227223
3.

Identification of novel scaffolds for IκB kinase beta inhibitor via a high-throughput screening TR-FRET assay.

Oh KS, Lee S, Choi JK, Lee BH.

Comb Chem High Throughput Screen. 2010 Nov;13(9):790-7.

PMID:
20615197
4.

A real-time, fluorescence-based assay for Rho-associated protein kinase activity.

Kelly MI, Bechtel TJ, Reddy DR, Hankore ED, Beck JR, Stains CI.

Anal Chim Acta. 2015 Sep 3;891:284-90. doi: 10.1016/j.aca.2015.07.058. Epub 2015 Aug 12.

PMID:
26388388
5.

Design of novel rho kinase inhibitors using energy based pharmacophore modeling, shape-based screening, in silico virtual screening, and biological evaluation.

Mishra RK, Alokam R, Singhal SM, Srivathsav G, Sriram D, Kaushik-Basu N, Manvar D, Yogeeswari P.

J Chem Inf Model. 2014 Oct 27;54(10):2876-86. doi: 10.1021/ci5004703. Epub 2014 Oct 9.

PMID:
25254429
6.

Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors.

Gong LL, Fang LH, Peng JH, Liu AL, Du GH.

J Biotechnol. 2010 Feb 1;145(3):295-303. doi: 10.1016/j.jbiotec.2009.12.003. Epub 2009 Dec 4.

PMID:
19963024
7.

Development, validation and implementation of immobilized metal affinity for phosphochemicals (IMAP)-based high-throughput screening assays for low-molecular-weight compound libraries.

Sharlow ER, Leimgruber S, Yellow-Duke A, Barrett R, Wang QJ, Lazo JS.

Nat Protoc. 2008;3(8):1350-63. doi: 10.1038/nprot.2008.111.

PMID:
18714303
8.

A Dual Readout Assay Based on Fluorescence Polarization and Time-Resolved Fluorescence Resonance Energy Transfer to Screen for RSK1 Inhibitors.

Jeong EM, Lee MY, Lee JH, Lee BH, Oh KS.

Biol Pharm Bull. 2016;39(4):547-55. doi: 10.1248/bpb.b15-00808.

9.

High-throughput screening against ~6.1 million structurally diverse, lead-like compounds to discover novel ROCK inhibitors for cerebral injury recovery.

Gong H, Yuan Z, Zhan L.

Mol Divers. 2016 May;20(2):537-49. doi: 10.1007/s11030-015-9650-y. Epub 2015 Dec 23.

PMID:
26700101
10.

Stepwise high-throughput virtual screening of Rho kinase inhibitors from natural product library and potential therapeutics for pulmonary hypertension.

Su H, Yan J, Xu J, Fan XZ, Sun XL, Chen KY.

Pharm Biol. 2015 Aug;53(8):1201-6. doi: 10.3109/13880209.2014.970287. Epub 2015 Apr 8.

PMID:
25853972
11.

Time-Resolved Fluorescence Resonance Energy Transfer Assay for Discovery of Small-Molecule Inhibitors of Methyl-CpG Binding Domain Protein 2.

Wyhs N, Walker D, Giovinazzo H, Yegnasubramanian S, Nelson WG.

J Biomol Screen. 2014 Aug;19(7):1060-9. doi: 10.1177/1087057114526433. Epub 2014 Mar 7.

12.

Analysis of Iterative Screening with Stepwise Compound Selection Based on Novartis In-house HTS Data.

Paricharak S, IJzerman AP, Bender A, Nigsch F.

ACS Chem Biol. 2016 May 20;11(5):1255-64. doi: 10.1021/acschembio.6b00029. Epub 2016 Feb 26.

PMID:
26878899
13.

Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase.

Morwick T, Büttner FH, Cywin CL, Dahmann G, Hickey E, Jakes S, Kaplita P, Kashem MA, Kerr S, Kugler S, Mao W, Marshall D, Paw Z, Shih CK, Wu F, Young E.

J Med Chem. 2010 Jan 28;53(2):759-77. doi: 10.1021/jm9014263.

PMID:
20000469
14.

A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.

Sharma LK, Leonardi R, Lin W, Boyd VA, Goktug A, Shelat AA, Chen T, Jackowski S, Rock CO.

J Med Chem. 2015 Feb 12;58(3):1563-8. doi: 10.1021/jm501585q. Epub 2015 Jan 21.

15.

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules.

Andrews PD, Becroft M, Aspegren A, Gilmour J, James MJ, McRae S, Kime R, Allcock RW, Abraham A, Jiang Z, Strehl R, Mountford JC, Milligan G, Houslay MD, Adams DR, Frearson JA.

Biochem J. 2010 Nov 15;432(1):21-33. doi: 10.1042/BJ20101022.

PMID:
20854259
16.

Fluorescence labels in kinases: a high-throughput kinase binding assay for the identification of DFG-out binding ligands.

Simard JR, Rauh D.

Methods Mol Biol. 2012;800:95-117. doi: 10.1007/978-1-61779-349-3_8.

PMID:
21964785
17.

Discovery of Rho-kinase inhibitors by docking-based virtual screening.

Shen M, Yu H, Li Y, Li P, Pan P, Zhou S, Zhang L, Li S, Lee SM, Hou T.

Mol Biosyst. 2013 Jun;9(6):1511-21. doi: 10.1039/c3mb00016h. Epub 2013 Apr 3.

PMID:
23549429
18.

High-throughput virtual screening using quantum mechanical probes: discovery of selective kinase inhibitors.

Zhou T, Caflisch A.

ChemMedChem. 2010 Jul 5;5(7):1007-14. doi: 10.1002/cmdc.201000085.

PMID:
20540063
19.

Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

Ray P, Wright J, Adam J, Bennett J, Boucharens S, Black D, Cook A, Brown AR, Epemolu O, Fletcher D, Haunso A, Huggett M, Jones P, Laats S, Lyons A, Mestres J, de Man J, Morphy R, Rankovic Z, Sherborne B, Sherry L, van Straten N, Westwood P, Zaman GZ.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):97-101. doi: 10.1016/j.bmcl.2010.11.060. Epub 2010 Nov 19.

PMID:
21145740
20.

Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase.

Kast R, Schirok H, Figueroa-Pérez S, Mittendorf J, Gnoth MJ, Apeler H, Lenz J, Franz JK, Knorr A, Hütter J, Lobell M, Zimmermann K, Münter K, Augstein KH, Ehmke H, Stasch JP.

Br J Pharmacol. 2007 Dec;152(7):1070-80. Epub 2007 Oct 15.

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