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22933814,27552848,28661008,29243813,26608980,29324401,27757951,30308427,24630809,25684224,23503548,27841445,16278088,26204241,24245810,27922722,31608438,28395124,20091617,26147937,31627041,16146430,22595362,17903391,30194755,20071075,27756024,24488654,17553118,25470302,20462801,23128439,15820347,8965976,21316267,8006647,27438183,21711253,26675554,21159526,19674045,27452623,26216692,27933615,34246881,7851677,31166022,12651078,20559266,19423296,15642496,26298867,19434440,26088885,23123641,24998415,20502135,23680820,10210035,33006755,22516508,33635777,20517209,8601999,21322824,16437428,17651416,10691121,22683226,8174515,20888266,26716580,20559276,29253909,18182645,9127726,27819746,19317886,17561956,28623754,11952768,17055681,25354543,29369348,30096625,11687121,27889312,15694569,9738674,14745062,16886974,12534314,19054403,32769040,23774199,12027913,15009219,33838758,19821367,17201701,12558570,30500483,26709103,26786929,11879339,27714769,27553940,7823066,32679487,23938015,31574428,31276728,11148232,12535420,17283312,28121917,33452703,21062333,16417534,12073283,30959275,9627208,28931473,12027911,11737159,11051122,14741184,16117145,22258989,30308428,27779771,21531583,10897159,10530677,8112239,26148132,32944934,29428922,14642996,26062590,7781190,28854405,30675751,14636332,12243000,28324910,34896814,21936590,16420982,9153724,8039482,14636317,16227648,24346821,7585685,10908558,31812127,33423017,7913793,23037607,33078729,28235655,28974841,12614309,21263139,28826049,27423106,12651079,29897625,26580100,29197669,10867972,11899842,26182605,14745061,19102836,31493736,32847927,34468899,10999556,32406290,10049961,2111768,15046269,23933673,11737172,17382828,11347330,8013448,27736657,15679515,32885414,12651080,29315457,3142761,1396534,12185762,30682680,10406359,11128246,9764730,16361605,35763982,24311644,31195326,14667959,33838757,29270989,1733749,17432091,25591652,30933252,9003978,9818846,36219797,14630506,2124033,22940281,6816580,28416782,31035244,9578032,10515178,7807738,11952764,2036618,11422339,11105300,30066796,22983242,8784211,26798511,32512368,35429132,11502910,30642405,3928820,31755090,25814391,33957390,14745048,15304598,31111485,12350379,3093212,25255292,14527502,32256625,31828782,29415871,11706106,36352605,16523355,10962216,14639055,17899513,33220583,28745680,29450890,30009654,35594744,24798217,1733751,14669138,32163888,27915489,8039464,26223287,12743236,32179501,20055770,11784375,12752471,16930945,29427834,9952267,10768154,29177594,17948211,32207738,17625106,9262135,9578000,27988477,28814836,22611673,31280704,9276111,29957441,29889310,19076986,30681492,26773675,12220322,7710545,8195585,8174518,36754633,12601094,9627202,28682924,1344777,10851665,12558576,11380576,21107994,15129834,34590547,7988504,20111854,11993529,25359262,16685465,26432008,9008516,28279893,25996875,18684236,29861526,26353448,35985165,25558587,33508749,16060944,20424903,7495189,21395360,35854146,8660147,14533077,10094253,31731108,24324971,8859063,8830063,3134192,29975072,12694683,14510829,8167962,20033304,29453114,12180998,28940083,26594847,11564124,14763951,22613103,10897162,33875373,34438055,28595756,32193854,23921717,11425954,20420832,17382827,19921623,6424398,8000719,8956924,11789435,30326332,9591300,7988505,28282542,11301223,8635429,34670882,31715510,22169571,28401980,32302941,33834715,36281939,22180362,10513696,32841918,17128563,35271996,29607916,6426944,31408897,18702221,9114913,18369598,12132136,29210977,11518627,36184821,8243375,34798461,17006857,11077456,10328256,29360159,29504704,3121291,3127196,22580532,33578439,1888646,12651077,28822307,35339390,19415165,33334546,17979081,30296665,1900790,33992932,32339984,16180937,14610123,34370412,26521756,29758362,27162008,28958730,23888467,8039481,11904240,2289480,3084230,11461801,25513768,7925146,31299852,34175264,33786324,14706729,28976412,2044503,17696575,8504796,21389934,24906211,35240475,8082630,9627200,30884401,10522867,9631375,27854111,2507304,30290325,21761951,29175693,31068480,8608437,33345323,24292995,14741183,11255074,32247529,8603630,16978035,32109858,2444427,14518681,9593230,22994584,30807537,27131914,28070260,11823111,31299525,24783423,2842127,1493787,32068241,35810053,14630505,32790974,36816301,20689955,34296824,12907277,7694990,22591328,30052270,19317105,3137020,12697135,3930105,3130892,22814014,25298593,20644907,27841198,2013529,30010307,33444989,11463516,9827229,8232943,21088977,121870,23676933,8112246,3146223,30487494,34017250,1396434,32817177,2123157,8374915,33314118,8809226,25819874,3144581,9593232,28570963,33378111,24856909,19236179,30908087,30965274,33735464,24437529,12449849,31726425,9003968,1743159,9186252,17607530,29196247,1618179,31743818,35623138,27581218,36054499,15111693,7649133,28575765,31168497,21569539,35676088,3105964,9781552,29648925,30234559,19640350,8044455,12830503,2500138,25282706,30334528,11300327,22464175,10924866,33271444,9579909,24051577,33075673,25443723,9578044,12694690,18728811,30238679,28783998,30725538,3093214,9888492,6810648,29943451,37031583,7495191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Results by year

Year	Number of Results
1979	4
1980	1
1982	5
1983	2
1984	2
1985	4
1986	8
1987	7
1988	13
1989	10
1990	15
1991	10
1992	14
1993	15
1994	25
1995	18
1996	13
1997	16
1998	23
1999	18
2000	24
2001	22
2002	25
2003	40
2004	16
2005	11
2006	12
2007	22
2008	9
2009	15
2010	23
2011	20
2012	21
2013	24
2014	34
2015	37
2016	42
2017	53
2018	65
2019	63
2020	71
2021	68
2022	51
2023	11
2024	0

916 results

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Page 1

KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy.

Trinka E, Marson AG, Van Paesschen W, Kälviäinen R, Marovac J, Duncan B, Buyle S, Hallström Y, Hon P, Muscas GC, Newton M, Meencke HJ, Smith PE, Pohlmann-Eden B; KOMET Study Group. Trinka E, et al. J Neurol Neurosurg Psychiatry. 2013 Oct;84(10):1138-47. doi: 10.1136/jnnp-2011-300376. Epub 2012 Aug 29. J Neurol Neurosurg Psychiatry. 2013. PMID: 22933814 Clinical Trial.

Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study.

Pohlmann-Eden B, Marson AG, Noack-Rink M, Ramirez F, Tofighy A, Werhahn KJ, Wild I, Trinka E. Pohlmann-Eden B, et al. BMC Neurol. 2016 Aug 23;16(1):149. doi: 10.1186/s12883-016-0663-7. BMC Neurol. 2016. PMID: 27552848 Free PMC article. Clinical Trial.

Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.

Nevitt SJ, Sudell M, Weston J, Tudur Smith C, Marson AG. Nevitt SJ, et al. Cochrane Database Syst Rev. 2017 Jun 29;6(6):CD011412. doi: 10.1002/14651858.CD011412.pub2. Cochrane Database Syst Rev. 2017. PMID: 28661008 Free PMC article. Updated. Review.

Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.

Nevitt SJ, Sudell M, Weston J, Tudur Smith C, Marson AG. Nevitt SJ, et al. Cochrane Database Syst Rev. 2017 Dec 15;12(12):CD011412. doi: 10.1002/14651858.CD011412.pub3. Cochrane Database Syst Rev. 2017. PMID: 29243813 Free PMC article. Updated. Review.

Long-term Effectiveness of Antiepileptic Drug Monotherapy in Partial Epileptic Patients: A 7-year Study in an Epilepsy Center in China.

Zhu F, Lang SY, Wang XQ, Shi XB, Ma YF, Zhang X, Chen YN, Zhang JT. Zhu F, et al. Chin Med J (Engl). 2015 Nov 20;128(22):3015-22. doi: 10.4103/0366-6999.168968. Chin Med J (Engl). 2015. PMID: 26608980 Free PMC article.

Unblinded, randomized multicenter trial comparing lamotrigine and valproate combination with controlled-release carbamazepine monotherapy as initial drug regimen in untreated epilepsy.

Lee BI, No SK, Yi SD, Lee HW, Kim OJ, Kim SH, Kim MK, Kim SE, Kim YS, Kim JM, Lee SJ, Shin DJ, Park SP, Kim YI, Heo K, Cho YW, Cho YJ, Kim YN. Lee BI, et al. Seizure. 2018 Feb;55:17-24. doi: 10.1016/j.seizure.2017.12.008. Epub 2017 Dec 29. Seizure. 2018. PMID: 29324401 Free article. Clinical Trial.

Efficacy and tolerability of anti-epileptic drugs-an internet study.

Wieshmann UC, Baker G. Wieshmann UC, et al. Acta Neurol Scand. 2017 May;135(5):533-539. doi: 10.1111/ane.12698. Epub 2016 Oct 18. Acta Neurol Scand. 2017. PMID: 27757951

Efficacy of levetiracetam for reducing rolandic discharges in comparison with carbamazepine and valproate sodium in rolandic epilepsy.

Kanemura H, Sano F, Ohyama T, Aihara M. Kanemura H, et al. Seizure. 2018 Nov;62:79-83. doi: 10.1016/j.seizure.2018.10.002. Epub 2018 Oct 3. Seizure. 2018. PMID: 30308427 Free article.

Measurement of levetiracetam drug levels to assist with seizure control and monitoring of drug interactions with other anti-epileptic medications (AEMs).

Stepanova D, Beran RG. Stepanova D, et al. Seizure. 2014 May;23(5):371-6. doi: 10.1016/j.seizure.2014.02.003. Epub 2014 Feb 17. Seizure. 2014. PMID: 24630809 Free article.

A randomized, double-blind comparison of antiepileptic drug treatment in the elderly with new-onset focal epilepsy.

Werhahn KJ, Trinka E, Dobesberger J, Unterberger I, Baum P, Deckert-Schmitz M, Kniess T, Schmitz B, Bernedo V, Ruckes C, Ehrlich A, Krämer G. Werhahn KJ, et al. Epilepsia. 2015 Mar;56(3):450-9. doi: 10.1111/epi.12926. Epub 2015 Feb 12. Epilepsia. 2015. PMID: 25684224 Free article. Clinical Trial.

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