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Items: 1 to 20 of 104

1.

PPARδ activation protects endothelial function in diabetic mice.

Tian XY, Wong WT, Wang N, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SS, Chen ZY, Cooke JP, Yao X, Huang Y.

Diabetes. 2012 Dec;61(12):3285-93. doi: 10.2337/db12-0117. Epub 2012 Aug 28.

2.

Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway.

Cheang WS, Tian XY, Wong WT, Lau CW, Lee SS, Chen ZY, Yao X, Wang N, Huang Y.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):830-6. doi: 10.1161/ATVBAHA.113.301938. Epub 2014 Jan 30.

3.

Peroxisome proliferator-activated receptor δ agonist GW1516 attenuates diet-induced aortic inflammation, insulin resistance, and atherosclerosis in low-density lipoprotein receptor knockout mice.

Bojic LA, Burke AC, Chhoker SS, Telford DE, Sutherland BG, Edwards JY, Sawyez CG, Tirona RG, Yin H, Pickering JG, Huff MW.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):52-60. doi: 10.1161/ATVBAHA.113.301830. Epub 2013 Oct 24.

4.

Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARδ signaling pathway.

Choy KW, Mustafa MR, Lau YS, Liu J, Murugan D, Lau CW, Wang L, Zhao L, Huang Y.

Biochem Pharmacol. 2016 Sep 15;116:51-62. doi: 10.1016/j.bcp.2016.07.013. Epub 2016 Jul 20.

PMID:
27449753
5.

Improved insulin sensitivity and islet function after PPARdelta activation in diabetic db/db mice.

Winzell MS, Wulff EM, Olsen GS, Sauerberg P, Gotfredsen CF, Ahrén B.

Eur J Pharmacol. 2010 Jan 25;626(2-3):297-305. doi: 10.1016/j.ejphar.2009.09.053. Epub 2009 Oct 8.

PMID:
19818749
6.

Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice.

Zhang Y, Liu J, Tian XY, Wong WT, Chen Y, Wang L, Luo J, Cheang WS, Lau CW, Kwan KM, Wang N, Yao X, Huang Y.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):152-9. doi: 10.1161/ATVBAHA.113.302696. Epub 2013 Nov 7.

7.

Uncoupling protein-2 protects endothelial function in diet-induced obese mice.

Tian XY, Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X, Huang Y.

Circ Res. 2012 Apr 27;110(9):1211-6. doi: 10.1161/CIRCRESAHA.111.262170. Epub 2012 Mar 29.

8.

Pharmacological activation of peroxisome proliferator-activated receptor δ improves insulin resistance and hepatic steatosis in high fat diet-induced diabetic mice.

Wu HT, Chen CT, Cheng KC, Li YX, Yeh CH, Cheng JT.

Horm Metab Res. 2011 Aug;43(9):631-5. doi: 10.1055/s-0031-1280781. Epub 2011 Jul 1.

PMID:
21725906
9.

Osteocalcin attenuates high fat diet-induced impairment of endothelium-dependent relaxation through Akt/eNOS-dependent pathway.

Dou J, Li H, Ma X, Zhang M, Fang Q, Nie M, Bao Y, Jia W.

Cardiovasc Diabetol. 2014 Apr 7;13:74. doi: 10.1186/1475-2840-13-74.

10.

Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice.

Cheang WS, Wong WT, Tian XY, Yang Q, Lee HK, He GW, Yao X, Huang Y.

Cardiovasc Res. 2011 Nov 1;92(2):267-75. doi: 10.1093/cvr/cvr233. Epub 2011 Aug 29.

PMID:
21875904
11.

Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity.

Toral M, Gómez-Guzmán M, Jiménez R, Romero M, Zarzuelo MJ, Utrilla MP, Hermenegildo C, Cogolludo Á, Pérez-Vizcaíno F, Gálvez J, Duarte J.

J Hypertens. 2015 Sep;33(9):1831-44. doi: 10.1097/HJH.0000000000000634.

PMID:
26147382
12.

Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice.

Qin X, Xie X, Fan Y, Tian J, Guan Y, Wang X, Zhu Y, Wang N.

Hepatology. 2008 Aug;48(2):432-41. doi: 10.1002/hep.22334.

PMID:
18627005
13.

A nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist reverses endothelial dysfunction in diabetic (db/db-/-) mice.

Howarth AG, Wiehler WB, Pannirselvam M, Jiang Y, Berger JP, Severson D, Anderson TJ, Triggle CR.

J Pharmacol Exp Ther. 2006 Jan;316(1):364-70. Epub 2005 Oct 25.

14.

Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice.

Molnar J, Yu S, Mzhavia N, Pau C, Chereshnev I, Dansky HM.

Circ Res. 2005 Jun 10;96(11):1178-84. Epub 2005 May 5.

15.

Exercise improves the dilatation function of mesenteric arteries in postmyocardial infarction rats via a PI3K/Akt/eNOS pathway-mediated mechanism.

Wang Y, Wang S, Wier WG, Zhang Q, Jiang H, Li Q, Chen S, Tian Z, Li Y, Yu X, Zhao M, Liu J, Yang J, Zhang J, Zang W.

Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H2097-106. doi: 10.1152/ajpheart.00701.2010. Epub 2010 Oct 8.

PMID:
20935150
16.

Activation of peroxisome proliferator-activated receptor delta inhibits streptozotocin-induced diabetic nephropathy through anti-inflammatory mechanisms in mice.

Matsushita Y, Ogawa D, Wada J, Yamamoto N, Shikata K, Sato C, Tachibana H, Toyota N, Makino H.

Diabetes. 2011 Mar;60(3):960-8. doi: 10.2337/db10-1361. Epub 2011 Jan 26.

17.

Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice.

Liu J, Wang L, Tian XY, Liu L, Wong WT, Zhang Y, Han QB, Ho HM, Wang N, Wong SL, Chen ZY, Yu J, Ng CF, Yao X, Huang Y.

Diabetes. 2015 May;64(5):1564-75. doi: 10.2337/db14-1391. Epub 2014 Dec 4.

18.

Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases.

Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD.

J Physiol. 2009 Aug 1;587(Pt 15):3911-20. doi: 10.1113/jphysiol.2009.172916. Epub 2009 Jun 8.

19.

Peroxisome proliferator-activated receptor-delta agonist enhances vasculogenesis by regulating endothelial progenitor cells through genomic and nongenomic activations of the phosphatidylinositol 3-kinase/Akt pathway.

Han JK, Lee HS, Yang HM, Hur J, Jun SI, Kim JY, Cho CH, Koh GY, Peters JM, Park KW, Cho HJ, Lee HY, Kang HJ, Oh BH, Park YB, Kim HS.

Circulation. 2008 Sep 2;118(10):1021-33. doi: 10.1161/CIRCULATIONAHA.108.777169. Epub 2008 Aug 18.

20.

Supplementation of cyanidin-3-O-β-glucoside promotes endothelial repair and prevents enhanced atherogenesis in diabetic apolipoprotein E-deficient mice.

Zhang Y, Wang X, Wang Y, Liu Y, Xia M.

J Nutr. 2013 Aug;143(8):1248-53. doi: 10.3945/jn.113.177451. Epub 2013 Jun 12.

PMID:
23761653

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