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Items: 1 to 20 of 116

1.

Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and activator of transcription 3 (STAT3).

Millonig G, Ganzleben I, Peccerella T, Casanovas G, Brodziak-Jarosz L, Breitkopf-Heinlein K, Dick TP, Seitz HK, Muckenthaler MU, Mueller S.

J Biol Chem. 2012 Oct 26;287(44):37472-82. doi: 10.1074/jbc.M112.358911. Epub 2012 Aug 29.

2.

STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo.

Pietrangelo A, Dierssen U, Valli L, Garuti C, Rump A, Corradini E, Ernst M, Klein C, Trautwein C.

Gastroenterology. 2007 Jan;132(1):294-300. Epub 2006 Oct 17. Erratum in: Gastroenterology. 2007 Mar;132(3):1208.

PMID:
17241879
3.

Interleukin-6 induces hepcidin expression through STAT3.

Wrighting DM, Andrews NC.

Blood. 2006 Nov 1;108(9):3204-9. Epub 2006 Jul 11.

4.

ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3.

Choi SO, Cho YS, Kim HL, Park JW.

Biochem Biophys Res Commun. 2007 Apr 27;356(1):312-7. Epub 2007 Mar 5.

PMID:
17349976
5.

Hydrogen Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 Secretion and Promoting SIRT1-Mediated STAT3 Deacetylation.

Xin H, Wang M, Tang W, Shen Z, Miao L, Wu W, Li C, Wang X, Xin X, Zhu YZ.

Antioxid Redox Signal. 2016 Jan 10;24(2):70-83. doi: 10.1089/ars.2015.6315. Epub 2015 Sep 3.

6.

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice.

De Domenico I, Zhang TY, Koening CL, Branch RW, London N, Lo E, Daynes RA, Kushner JP, Li D, Ward DM, Kaplan J.

J Clin Invest. 2010 Jul;120(7):2395-405. doi: 10.1172/JCI42011. Epub 2010 Jun 7.

7.

Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling.

Chaston TB, Matak P, Pourvali K, Srai SK, McKie AT, Sharp PA.

Am J Physiol Cell Physiol. 2011 Apr;300(4):C888-95. doi: 10.1152/ajpcell.00121.2010. Epub 2011 Feb 2.

8.

In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2.

Maes K, Nemeth E, Roodman GD, Huston A, Esteve F, Freytes C, Callander N, Katodritou E, Tussing-Humphreys L, Rivera S, Vanderkerken K, Lichtenstein A, Ganz T.

Blood. 2010 Nov 4;116(18):3635-44. doi: 10.1182/blood-2010-03-274571. Epub 2010 Aug 2.

9.

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation.

Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU.

Blood. 2007 Jan 1;109(1):353-8. Epub 2006 Aug 31.

10.

Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli.

Huang H, Constante M, Layoun A, Santos MM.

Blood. 2009 Apr 9;113(15):3593-9. doi: 10.1182/blood-2008-08-173641. Epub 2009 Feb 9.

11.

Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways.

Shin DY, Chung J, Joe Y, Pae HO, Chang KC, Cho GJ, Ryter SW, Chung HT.

Blood. 2012 Mar 15;119(11):2523-32. doi: 10.1182/blood-2011-07-366690. Epub 2012 Jan 19.

12.

STAT3 signaling within hepatocytes is required for anemia of inflammation in vivo.

Sakamori R, Takehara T, Tatsumi T, Shigekawa M, Hikita H, Hiramatsu N, Kanto T, Hayashi N.

J Gastroenterol. 2010 Feb;45(2):244-8. doi: 10.1007/s00535-009-0159-y. Epub 2009 Dec 1.

PMID:
20091060
13.

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells.

Verga Falzacappa MV, Casanovas G, Hentze MW, Muckenthaler MU.

J Mol Med (Berl). 2008 May;86(5):531-40. doi: 10.1007/s00109-008-0313-7. Epub 2008 Apr 18.

PMID:
18421430
14.

Aspirin down Regulates Hepcidin by Inhibiting NF-κB and IL6/JAK2/STAT3 Pathways in BV-2 Microglial Cells Treated with Lipopolysaccharide.

Li WY, Li FM, Zhou YF, Wen ZM, Ma J, Ya K, Qian ZM.

Int J Mol Sci. 2016 Dec 16;17(12). pii: E1921. doi: 10.3390/ijms17121921.

15.

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD.

Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU.

J Mol Med (Berl). 2009 May;87(5):471-80. doi: 10.1007/s00109-009-0447-2. Epub 2009 Feb 20.

PMID:
19229506
16.

Activated macrophages induce hepcidin expression in HuH7 hepatoma cells.

Matak P, Chaston TB, Chung B, Srai SK, McKie AT, Sharp PA.

Haematologica. 2009 Jun;94(6):773-80. doi: 10.3324/haematol.2008.003400. Epub 2009 May 19.

17.

A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.

Foka P, Dimitriadis A, Kyratzopoulou E, Giannimaras DA, Sarno S, Simos G, Georgopoulou U, Mamalaki A.

Cell Mol Life Sci. 2014 Nov;71(21):4243-58. doi: 10.1007/s00018-014-1621-4. Epub 2014 Apr 10.

PMID:
24718935
18.

Ceramide Induces Human Hepcidin Gene Transcription through JAK/STAT3 Pathway.

Lu S, Natarajan SK, Mott JL, Kharbanda KK, Harrison-Findik DD.

PLoS One. 2016 Jan 25;11(1):e0147474. doi: 10.1371/journal.pone.0147474. eCollection 2016.

19.

Iron-regulatory gene expression during liver regeneration.

Mollbrink A, Holmström P, Sjöström M, Hultcrantz R, Eriksson LC, Stål P.

Scand J Gastroenterol. 2012 May;47(5):591-600. doi: 10.3109/00365521.2012.661761. Epub 2012 Feb 27.

PMID:
22364558
20.

Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells.

Chung B, Matak P, McKie AT, Sharp P.

J Nutr. 2007 Nov;137(11):2366-70.

PMID:
17951471

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