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Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation.

Kim TS, Lee DH, Kim SK, Shin SY, Seo EJ, Lim DS.

Cancer Res. 2012 Oct 15;72(20):5386-95. doi: 10.1158/0008-5472.CAN-11-3956. Epub 2012 Aug 27.


MST1 limits the kinase activity of aurora B to promote stable kinetochore-microtubule attachment.

Oh HJ, Kim MJ, Song SJ, Kim T, Lee D, Kwon SH, Choi EJ, Lim DS.

Curr Biol. 2010 Mar 9;20(5):416-22. doi: 10.1016/j.cub.2009.12.054. Epub 2010 Feb 18.


Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases.

Avruch J, Praskova M, Ortiz-Vega S, Liu M, Zhang XF.

Methods Enzymol. 2006;407:290-310.


Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse.

Oh S, Lee D, Kim T, Kim TS, Oh HJ, Hwang CY, Kong YY, Kwon KS, Lim DS.

Mol Cell Biol. 2009 Dec;29(23):6309-20. doi: 10.1128/MCB.00551-09. Epub 2009 Sep 28.


Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer.

Hu W, Kavanagh JJ, Deaver M, Johnston DA, Freedman RS, Verschraegen CF, Sen S.

Oncol Res. 2005;15(1):49-57.


Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.

Graves JD, Draves KE, Gotoh Y, Krebs EG, Clark EA.

J Biol Chem. 2001 May 4;276(18):14909-15. Epub 2001 Feb 13.


Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis.

Morinaka A, Funato Y, Uesugi K, Miki H.

Oncogene. 2011 Oct 6;30(40):4208-18. doi: 10.1038/onc.2011.139. Epub 2011 Apr 25.


The Aurora kinases: role in cell transformation and tumorigenesis.

Katayama H, Brinkley WR, Sen S.

Cancer Metastasis Rev. 2003 Dec;22(4):451-64. Review.


Lymphoma development in Bax transgenic mice is inhibited by Bcl-2 and associated with chromosomal instability.

Luke JJ, Van De Wetering CI, Knudson CM.

Cell Death Differ. 2003 Jun;10(6):740-8.


The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylation.

Hergovich A, Kohler RS, Schmitz D, Vichalkovski A, Cornils H, Hemmings BA.

Curr Biol. 2009 Nov 3;19(20):1692-702. doi: 10.1016/j.cub.2009.09.020.


Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.

Foijer F, Xie SZ, Simon JE, Bakker PL, Conte N, Davis SH, Kregel E, Jonkers J, Bradley A, Sorger PK.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13427-32. doi: 10.1073/pnas.1400892111. Epub 2014 Sep 2.


p53 deficiency and misexpression of protein kinase CK2alpha collaborate in the development of thymic lymphomas in mice.

Landesman-Bollag E, Channavajhala PL, Cardiff RD, Seldin DC.

Oncogene. 1998 Jun 11;16(23):2965-74.


Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer.

Minoo P, Zlobec I, Baker K, Tornillo L, Terracciano L, Jass JR, Lugli A.

Mod Pathol. 2007 Mar;20(3):331-8. Epub 2007 Feb 2.


NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis.

Vichalkovski A, Gresko E, Cornils H, Hergovich A, Schmitz D, Hemmings BA.

Curr Biol. 2008 Dec 9;18(23):1889-95. doi: 10.1016/j.cub.2008.10.060.


The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility.

Tang F, Gill J, Ficht X, Barthlott T, Cornils H, Schmitz-Rohmer D, Hynx D, Zhou D, Zhang L, Xue G, Grzmil M, Yang Z, Hergovich A, Hollaender GA, Stein JV, Hemmings BA, Matthias P.

Sci Signal. 2015 Oct 6;8(397):ra100. doi: 10.1126/scisignal.aab2425.


Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis.

Lin Y, Khokhlatchev A, Figeys D, Avruch J.

J Biol Chem. 2002 Dec 13;277(50):47991-8001. Epub 2002 Oct 15.


hBUB1 defects in leukemia and lymphoma cells.

Ru HY, Chen RL, Lu WC, Chen JH.

Oncogene. 2002 Jul 11;21(30):4673-9.


Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity.

Song H, Oh S, Oh HJ, Lim DS.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):969-73. doi: 10.1016/j.bbrc.2009.11.175. Epub 2009 Dec 4.


Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation.

Ura S, Masuyama N, Graves JD, Gotoh Y.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10148-53. Epub 2001 Aug 21.

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