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Items: 1 to 20 of 107

1.

Tailored amino acid diversity for the evolution of antibody affinity.

González-Muñoz A, Bokma E, O'Shea D, Minton K, Strain M, Vousden K, Rossant C, Jermutus L, Minter R.

MAbs. 2012 Nov-Dec;4(6):664-72. doi: 10.4161/mabs.21728. Epub 2012 Aug 27.

3.

Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations.

Chen C, Roberts VA, Stevens S, Brown M, Stenzel-Poore MP, Rittenberg MB.

EMBO J. 1995 Jun 15;14(12):2784-94.

4.

Reducing epitope spread during affinity maturation of an anti-ganglioside GD2 antibody.

Hu J, Huang X, Ling CC, Bundle DR, Cheung NK.

J Immunol. 2009 Nov 1;183(9):5748-55. doi: 10.4049/jimmunol.0901409. Epub 2009 Oct 7.

5.
6.

Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site.

Schier R, McCall A, Adams GP, Marshall KW, Merritt H, Yim M, Crawford RS, Weiner LM, Marks C, Marks JD.

J Mol Biol. 1996 Nov 8;263(4):551-67.

PMID:
8918938
7.

Synthetic single-framework antibody library integrated with rapid affinity maturation by VL shuffling.

Brockmann EC, Akter S, Savukoski T, Huovinen T, Lehmusvuori A, Leivo J, Saavalainen O, Azhayev A, Lövgren T, Hellman J, Lamminmäki U.

Protein Eng Des Sel. 2011 Sep;24(9):691-700. doi: 10.1093/protein/gzr023. Epub 2011 Jun 16.

PMID:
21680620
8.

Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues.

Wu H, Nie Y, Huse WD, Watkins JD.

J Mol Biol. 1999 Nov 19;294(1):151-62.

PMID:
10556035
9.

Structure, function and properties of antibody binding sites.

Mian IS, Bradwell AR, Olson AJ.

J Mol Biol. 1991 Jan 5;217(1):133-51. Review.

PMID:
1988675
10.

Directed evolution for the development of conformation-specific affinity reagents using yeast display.

Weaver-Feldhaus JM, Miller KD, Feldhaus MJ, Siegel RW.

Protein Eng Des Sel. 2005 Nov;18(11):527-36. Epub 2005 Sep 26.

PMID:
16186140
11.

Tyrosine plays a dominant functional role in the paratope of a synthetic antibody derived from a four amino acid code.

Fellouse FA, Barthelemy PA, Kelley RF, Sidhu SS.

J Mol Biol. 2006 Mar 17;357(1):100-14. Epub 2005 Dec 19.

PMID:
16413576
12.

An integrated approach to extreme thermostabilization and affinity maturation of an antibody.

McConnell AD, Spasojevich V, Macomber JL, Krapf IP, Chen A, Sheffer JC, Berkebile A, Horlick RA, Neben S, King DJ, Bowers PM.

Protein Eng Des Sel. 2013 Feb;26(2):151-64. doi: 10.1093/protein/gzs090. Epub 2012 Nov 19.

PMID:
23173178
13.

Enhancement of scFv fragment reactivity with target antigens in binding assays following mixing with anti-tag monoclonal antibodies.

Wang X, Campoli M, Ko E, Luo W, Ferrone S.

J Immunol Methods. 2004 Nov;294(1-2):23-35.

PMID:
15604013
14.

Improving antibody affinity by mimicking somatic hypermutation in vitro.

Chowdhury PS, Pastan I.

Nat Biotechnol. 1999 Jun;17(6):568-72.

PMID:
10385321
15.

Humanization of a highly stable single-chain antibody by structure-based antigen-binding site grafting.

Villani ME, Morea V, Consalvi V, Chiaraluce R, Desiderio A, Benvenuto E, Donini M.

Mol Immunol. 2008 May;45(9):2474-85. doi: 10.1016/j.molimm.2008.01.016. Epub 2008 Mar 3.

PMID:
18313757
16.

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides.

Knappik A, Ge L, Honegger A, Pack P, Fischer M, Wellnhofer G, Hoess A, Wölle J, Plückthun A, Virnekäs B.

J Mol Biol. 2000 Feb 11;296(1):57-86.

PMID:
10656818
17.

Affinity maturation by semi-rational approaches.

Barderas R, Desmet J, Alard P, Casal JI.

Methods Mol Biol. 2012;907:463-86. doi: 10.1007/978-1-61779-974-7_27.

PMID:
22907369
18.

In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin.

Ho M, Kreitman RJ, Onda M, Pastan I.

J Biol Chem. 2005 Jan 7;280(1):607-17. Epub 2004 Oct 18.

19.

Expanding the conformational diversity by random insertions to CDRH2 results in improved anti-estradiol antibodies.

Lamminmäki U, Paupério S, Westerlund-Karlsson A, Karvinen J, Virtanen PL, Lövgren T, Saviranta P.

J Mol Biol. 1999 Aug 20;291(3):589-602.

PMID:
10448039
20.

Exploiting bias in a non-immune human antibody library to predict antigenicity.

Ackerman ME, Lai JI, Pastan I, Wittrup KD.

Protein Eng Des Sel. 2011 Nov;24(11):845-53. doi: 10.1093/protein/gzr046. Epub 2011 Sep 9.

PMID:
21908549

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