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[¹⁸F]FE@SNAP-A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): microfluidic and vessel-based approaches.

Philippe C, Ungersboeck J, Schirmer E, Zdravkovic M, Nics L, Zeilinger M, Shanab K, Lanzenberger R, Karanikas G, Spreitzer H, Viernstein H, Mitterhauser M, Wadsak W.

Bioorg Med Chem. 2012 Oct 1;20(19):5936-40. doi: 10.1016/j.bmc.2012.07.051. Epub 2012 Aug 7.


Radiosynthesis of [11C]SNAP-7941--the first PET-tracer for the melanin concentrating hormone receptor 1 (MCHR1).

Philippe C, Schirmer E, Mitterhauser M, Shanab K, Lanzenberger R, Karanikas G, Spreitzer H, Viernstein H, Wadsak W.

Appl Radiat Isot. 2012 Oct;70(10):2287-94. doi: 10.1016/j.apradiso.2012.07.010. Epub 2012 Jul 20.


Preclinical in vitro &in vivo evaluation of [(11)C]SNAP-7941 - the first PET tracer for the melanin concentrating hormone receptor 1.

Philippe C, Nics L, Zeilinger M, Kuntner C, Wanek T, Mairinger S, Shanab K, Spreitzer H, Viernstein H, Wadsak W, Mitterhauser M.

Nucl Med Biol. 2013 Oct;40(7):919-25. doi: 10.1016/j.nucmedbio.2013.05.010. Epub 2013 Jul 3.


Syntheses of precursors and reference compounds of the melanin-concentrating hormone receptor 1 (MCHR1) tracers [¹¹C]SNAP-7941 and [¹⁸F]FE@SNAP for positron emission tomography.

Schirmer E, Shanab K, Datterl B, Neudorfer C, Mitterhauser M, Wadsak W, Philippe C, Spreitzer H.

Molecules. 2013 Sep 30;18(10):12119-43. doi: 10.3390/molecules181012119.


Comparative autoradiographic in vitro investigation of melanin concentrating hormone receptor 1 ligands in the central nervous system.

Philippe C, Haeusler D, Fuchshuber F, Spreitzer H, Viernstein H, Hacker M, Wadsak W, Mitterhauser M.

Eur J Pharmacol. 2014 Jul 15;735:177-83. doi: 10.1016/j.ejphar.2014.04.020. Epub 2014 Apr 26.


Preparation and First Preclinical Evaluation of [(18)F]FE@SNAP: A Potential PET Tracer for the Melanin-Concentrating Hormone Receptor-1 (MCHR1).

Philippe C, Nics L, Zeilinger M, Schirmer E, Spreitzer H, Karanikas G, Lanzenberger R, Viernstein H, Wadsak W, Mitterhauser M.

Sci Pharm. 2013 Jul 1;81(3):625-39. doi: 10.3797/scipharm.1306-02. Print 2013 Jul-Sep.


[(18)F]FE@SNAP-a specific PET tracer for melanin-concentrating hormone receptor 1 imaging?

Philippe C, Haeusler D, Scherer T, Fürnsinn C, Zeilinger M, Wadsak W, Shanab K, Spreitzer H, Hacker M, Mitterhauser M.

EJNMMI Res. 2016 Dec;6(1):31. doi: 10.1186/s13550-016-0186-7. Epub 2016 Apr 1.


In vivo evaluation of radiotracers targeting the melanin-concentrating hormone receptor 1: [11C]SNAP-7941 and [18F]FE@SNAP reveal specific uptake in the ventricular system.

Zeilinger M, Dumanic M, Pichler F, Budinsky L, Wadsak W, Pallitsch K, Spreitzer H, Lanzenberger R, Hacker M, Mitterhauser M, Philippe C.

Sci Rep. 2017 Aug 14;7(1):8054. doi: 10.1038/s41598-017-08684-6.


First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography.

Schottelius M, Poethko T, Herz M, Reubi JC, Kessler H, Schwaiger M, Wester HJ.

Clin Cancer Res. 2004 Jun 1;10(11):3593-606.


Melanin concentrating hormone receptor 1 (MCHR1) antagonists-Still a viable approach for obesity treatment?

Högberg T, Frimurer TM, Sasmal PK.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6039-47. doi: 10.1016/j.bmcl.2012.08.025. Epub 2012 Aug 19.


Concise and high-yield synthesis of T808 and T808P for radiosynthesis of [(18)F]-T808, a PET tau tracer for Alzheimer's disease.

Gao M, Wang M, Zheng QH.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):254-7. doi: 10.1016/j.bmcl.2013.11.025. Epub 2013 Nov 20.


Fluorine-18 click radiosynthesis and preclinical evaluation of a new 18F-labeled folic acid derivative.

Ross TL, Honer M, Lam PY, Mindt TL, Groehn V, Schibli R, Schubiger PA, Ametamey SM.

Bioconjug Chem. 2008 Dec;19(12):2462-70. doi: 10.1021/bc800356r.


Radiosynthesis and preclinical evaluation of 18F-F13714 as a fluorinated 5-HT1A receptor agonist radioligand for PET neuroimaging.

Lemoine L, Becker G, Vacher B, Billard T, Lancelot S, Newman-Tancredi A, Zimmer L.

J Nucl Med. 2012 Jun;53(6):969-76. doi: 10.2967/jnumed.111.101212. Epub 2012 May 10.


Organomediated Enantioselective (18)F Fluorination for PET Applications.

Buckingham F, Kirjavainen AK, Forsback S, Krzyczmonik A, Keller T, Newington IM, Glaser M, Luthra SK, Solin O, Gouverneur V.

Angew Chem Int Ed Engl. 2015 Nov 2;54(45):13366-9. doi: 10.1002/anie.201506035. Epub 2015 Sep 11.


Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling.

Goldstein C, Schroeder JC, Fortin JP, Goss JM, Schaus SE, Beinborn M, Kopin AS.

J Pharmacol Exp Ther. 2010 Dec;335(3):799-806. doi: 10.1124/jpet.110.174029. Epub 2010 Sep 10.


Radiolabelling diverse positron emission tomography (PET) tracers using a single digital microfluidic reactor chip.

Chen S, Javed MR, Kim HK, Lei J, Lazari M, Shah GJ, van Dam RM, Keng PY, Kim CJ.

Lab Chip. 2014 Mar 7;14(5):902-10. doi: 10.1039/c3lc51195b.


Synthesis and in vitro evaluation of (18)F-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET.

Robins EG, Zhao Y, Khan I, Wilson A, Luthra SK, Rstad E.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1749-51. doi: 10.1016/j.bmcl.2010.01.052. Epub 2010 Jan 20.


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