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Items: 1 to 20 of 120

1.

Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.

Linsky TW, Fast W.

Bioorg Med Chem. 2012 Sep 15;20(18):5550-8. doi: 10.1016/j.bmc.2012.07.022. Epub 2012 Aug 3.

2.

Development of a dimethylarginine dimethylaminohydrolase (DDAH) assay for high-throughput chemical screening.

Ghebremariam YT, Erlanson DA, Yamada K, Cooke JP.

J Biomol Screen. 2012 Jun;17(5):651-61. doi: 10.1177/1087057112441521. Epub 2012 Mar 29.

3.
4.

A continuous, fluorescent, high-throughput assay for human dimethylarginine dimethylaminohydrolase-1.

Linsky T, Fast W.

J Biomol Screen. 2011 Oct;16(9):1089-97. doi: 10.1177/1087057111417712. Epub 2011 Sep 15.

5.

Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis.

Hartzoulakis B, Rossiter S, Gill H, O'Hara B, Steinke E, Gane PJ, Hurtado-Guerrero R, Leiper JM, Vallance P, Rust JM, Selwood DL.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):3953-6. Epub 2007 May 3.

PMID:
17543521
6.

Discovery of halopyridines as quiescent affinity labels: inactivation of dimethylarginine dimethylaminohydrolase.

Johnson CM, Linsky TW, Yoon DW, Person MD, Fast W.

J Am Chem Soc. 2011 Feb 9;133(5):1553-62. doi: 10.1021/ja109207m. Epub 2011 Jan 11.

7.

Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development.

Murphy RB, Tommasi S, Lewis BC, Mangoni AA.

Molecules. 2016 May 11;21(5). pii: E615. doi: 10.3390/molecules21050615. Review.

8.

Developing an irreversible inhibitor of human DDAH-1, an enzyme upregulated in melanoma.

Wang Y, Hu S, Gabisi AM Jr, Er JA, Pope A, Burstein G, Schardon CL, Cardounel AJ, Ekmekcioglu S, Fast W.

ChemMedChem. 2014 Apr;9(4):792-7. doi: 10.1002/cmdc.201300557. Epub 2014 Feb 26.

9.

Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.

Wang Y, Monzingo AF, Hu S, Schaller TH, Robertus JD, Fast W.

Biochemistry. 2009 Sep 15;48(36):8624-35. doi: 10.1021/bi9007098.

10.

Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1.

Tommasi S, Zanato C, Lewis BC, Nair PC, Dall'Angelo S, Zanda M, Mangoni AA.

Org Biomol Chem. 2015 Dec 14;13(46):11315-30. doi: 10.1039/c5ob01843a. Epub 2015 Sep 30.

PMID:
26420019
11.

On the mechanism of dimethylarginine dimethylaminohydrolase inactivation by 4-halopyridines.

Johnson CM, Monzingo AF, Ke Z, Yoon DW, Linsky TW, Guo H, Robertus JD, Fast W.

J Am Chem Soc. 2011 Jul 20;133(28):10951-9. doi: 10.1021/ja2033684. Epub 2011 Jun 23.

12.

Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase.

Kotthaus J, Schade D, Kotthaus J, Clement B.

J Enzyme Inhib Med Chem. 2012 Feb;27(1):24-8. doi: 10.3109/14756366.2011.573480. Epub 2011 Jul 8.

PMID:
21740101
13.

Substrate-assisted cysteine deprotonation in the mechanism of dimethylargininase (DDAH) from Pseudomonas aeruginosa.

Stone EM, Costello AL, Tierney DL, Fast W.

Biochemistry. 2006 May 2;45(17):5618-30.

PMID:
16634643
14.
15.

Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking.

Zhao H, Gartenmann L, Dong J, Spiliotopoulos D, Caflisch A.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2493-6. doi: 10.1016/j.bmcl.2014.04.017. Epub 2014 Apr 13.

PMID:
24767840
16.

Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.

Kotthaus J, Schade D, Muschick N, Beitz E, Clement B.

Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. doi: 10.1016/j.bmc.2008.10.058. Epub 2008 Oct 29.

PMID:
19013076
17.

Structural characterization and high-throughput screening of inhibitors of PvdQ, an NTN hydrolase involved in pyoverdine synthesis.

Drake EJ, Gulick AM.

ACS Chem Biol. 2011 Nov 18;6(11):1277-86. doi: 10.1021/cb2002973. Epub 2011 Sep 15.

18.

Efficient search of chemical space: navigating from fragments to structurally diverse chemotypes.

Wassermann AM, Kutchukian PS, Lounkine E, Luethi T, Hamon J, Bocker MT, Malik HA, Cowan-Jacob SW, Glick M.

J Med Chem. 2013 Nov 14;56(21):8879-91. doi: 10.1021/jm401309q. Epub 2013 Oct 31.

PMID:
24117015
19.

GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in humans.

Chobanyan K, Thum T, Suchy MT, Zhu B, Mitschke A, Gutzki FM, Beckmann B, Stichtenoth DO, Tsikas D.

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 15;858(1-2):32-41. Epub 2007 Aug 7.

PMID:
17825631
20.

Characterization and manipulation of the Pseudomonas aeruginosa dimethylarginine dimethylaminohydrolase monomer--dimer equilibrium.

Plevin MJ, Magalhães BS, Harris R, Sankar A, Perkins SJ, Driscoll PC.

J Mol Biol. 2004 Jul 30;341(1):171-84.

PMID:
15312771

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