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Crystal structure of human aurora B in complex with INCENP and VX-680.

Elkins JM, Santaguida S, Musacchio A, Knapp S.

J Med Chem. 2012 Sep 13;55(17):7841-8. doi: 10.1021/jm3008954. Epub 2012 Sep 4.


Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation.

Bolton MA, Lan W, Powers SE, McCleland ML, Kuang J, Stukenberg PT.

Mol Biol Cell. 2002 Sep;13(9):3064-77.


Mechanism of Aurora B activation by INCENP and inhibition by hesperadin.

Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A.

Mol Cell. 2005 Apr 29;18(3):379-91.


Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.

Wheatley SP, Henzing AJ, Dodson H, Khaled W, Earnshaw WC.

J Biol Chem. 2004 Feb 13;279(7):5655-60. Epub 2003 Nov 10.


Structure of Aurora B-INCENP in complex with barasertib reveals a potential transinhibitory mechanism.

Sessa F, Villa F.

Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):294-8. doi: 10.1107/S2053230X14002118. Epub 2014 Feb 19.


INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow.

Adams RR, Wheatley SP, Gouldsworthy AM, Kandels-Lewis SE, Carmena M, Smythe C, Gerloff DL, Earnshaw WC.

Curr Biol. 2000 Sep 7;10(17):1075-8.


Structural basis for binding of aurora-AG198N- INCENP complex: MD simulations and free energy calculations.

Tanneeru K, Guruprasad L.

Protein Pept Lett. 2013 Nov;20(11):1246-56.


Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B.

Hans F, Skoufias DA, Dimitrov S, Margolis RL.

Mol Biol Cell. 2009 Aug;20(15):3491-502. doi: 10.1091/mbc.E09-05-0370. Epub 2009 Jun 3.


Biochemical characterization of GSK1070916, a potent and selective inhibitor of Aurora B and Aurora C kinases with an extremely long residence time1.

Anderson K, Lai Z, McDonald OB, Stuart JD, Nartey EN, Hardwicke MA, Newlander K, Dhanak D, Adams J, Patrick D, Copeland RA, Tummino PJ, Yang J.

Biochem J. 2009 May 13;420(2):259-65. doi: 10.1042/BJ20090121.


INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.

Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC.

Curr Biol. 2001 Jun 5;11(11):886-90.


Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells.

Adams RR, Eckley DM, Vagnarelli P, Wheatley SP, Gerloff DL, Mackay AM, Svingen PA, Kaufmann SH, Earnshaw WC.

Chromosoma. 2001 May;110(2):65-74.


Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex.

Sasai K, Katayama H, Hawke DH, Sen S.

PLoS One. 2016 Jun 22;11(6):e0157305. doi: 10.1371/journal.pone.0157305. eCollection 2016.


Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.

Li X, Sakashita G, Matsuzaki H, Sugimoto K, Kimura K, Hanaoka F, Taniguchi H, Furukawa K, Urano T.

J Biol Chem. 2004 Nov 5;279(45):47201-11. Epub 2004 Aug 16.


The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis.

Samejima K, Platani M, Wolny M, Ogawa H, Vargiu G, Knight PJ, Peckham M, Earnshaw WC.

J Biol Chem. 2015 Aug 28;290(35):21460-72. doi: 10.1074/jbc.M115.645317. Epub 2015 Jul 14.


Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.

Honda R, Körner R, Nigg EA.

Mol Biol Cell. 2003 Aug;14(8):3325-41. Epub 2003 May 29.


INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization.

Xu Z, Ogawa H, Vagnarelli P, Bergmann JH, Hudson DF, Ruchaud S, Fukagawa T, Earnshaw WC, Samejima K.

J Cell Biol. 2009 Nov 30;187(5):637-53. doi: 10.1083/jcb.200906053. Erratum in: J Cell Biol. 2010 Feb 22;188(4):611.


Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis.

Xu Z, Vagnarelli P, Ogawa H, Samejima K, Earnshaw WC.

J Biol Chem. 2010 Dec 17;285(51):40163-70. doi: 10.1074/jbc.M110.181545. Epub 2010 Oct 18.


VX-680 inhibits Aurora A and Aurora B kinase activity in human cells.

Tyler RK, Shpiro N, Marquez R, Eyers PA.

Cell Cycle. 2007 Nov 15;6(22):2846-54. Epub 2007 Aug 27.


The chromosomal passenger complex: one for all and all for one.

Ruchaud S, Carmena M, Earnshaw WC.

Cell. 2007 Oct 19;131(2):230-1.

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