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Items: 1 to 20 of 95

1.

Identification of antitubercular benzothiazinone compounds by ligand-based design.

Karoli T, Becker B, Zuegg J, Möllmann U, Ramu S, Huang JX, Cooper MA.

J Med Chem. 2012 Sep 13;55(17):7940-4. doi: 10.1021/jm3008882.

PMID:
22916795
2.

Synthesis and structure-activity relationships evaluation of benzothiazinone derivatives as potential anti-tubercular agents.

Gao C, Ye TH, Wang NY, Zeng XX, Zhang LD, Xiong Y, You XY, Xia Y, Xu Y, Peng CT, Zuo WQ, Wei Y, Yu LT.

Bioorg Med Chem Lett. 2013 Sep 1;23(17):4919-22. doi: 10.1016/j.bmcl.2013.06.069.

PMID:
23886691
3.

Synthesis and antitubercular evaluation of 4-carbonyl piperazine substituted 1,3-benzothiazin-4-one derivatives.

Peng CT, Gao C, Wang NY, You XY, Zhang LD, Zhu YX, Xv Y, Zuo WQ, Ran K, Deng HX, Lei Q, Xiao KJ, Yu LT.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1373-6. doi: 10.1016/j.bmcl.2015.02.061.

PMID:
25754492
4.

Bridging the gap between a TB drug and its target.

Cook GM, Heikal A.

Sci Transl Med. 2012 Sep 5;4(150):150fs33. doi: 10.1126/scitranslmed.3004816.

PMID:
22956196
5.

[Development of antituberculous drugs: current status and future prospects].

Tomioka H, Namba K.

Kekkaku. 2006 Dec;81(12):753-74. Review. Japanese.

PMID:
17240921
6.

[Prospects for development of new antituberculous drugs].

Tomioka H.

Kekkaku. 2002 Aug;77(8):573-84. Japanese.

PMID:
12235850
7.

[Recent progress in mycobacteriology].

Okada M, Kobayashi K.

Kekkaku. 2007 Oct;82(10):783-99. Japanese.

PMID:
18018602
8.

L-proline-catalysed facile green protocol for the synthesis and antimycobacterial evaluation of [1,4]-thiazines.

Indumathi S, Perumal S, Banerjee D, Yogeeswari P, Sriram D.

Eur J Med Chem. 2009 Dec;44(12):4978-84. doi: 10.1016/j.ejmech.2009.09.001.

PMID:
19781824
9.

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.

Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST.

Science. 2009 May 8;324(5928):801-4. doi: 10.1126/science.1171583.

10.

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance.

Manina G, Bellinzoni M, Pasca MR, Neres J, Milano A, Ribeiro AL, Buroni S, Skovierová H, Dianišková P, Mikušová K, Marák J, Makarov V, Giganti D, Haouz A, Lucarelli AP, Degiacomi G, Piazza A, Chiarelli LR, De Rossi E, Salina E, Cole ST, Alzari PM, Riccardi G.

Mol Microbiol. 2010 Sep;77(5):1172-85. doi: 10.1111/j.1365-2958.2010.07277.x.

11.
12.

Thiolates chemically induce redox activation of BTZ043 and related potent nitroaromatic anti-tuberculosis agents.

Tiwari R, Moraski GC, Krchňák V, Miller PA, Colon-Martinez M, Herrero E, Oliver AG, Miller MJ.

J Am Chem Soc. 2013 Mar 6;135(9):3539-49. doi: 10.1021/ja311058q.

13.

Schiff bases of indoline-2,3-dione (isatin) derivatives and nalidixic acid carbohydrazide, synthesis, antitubercular activity and pharmacophoric model building.

Aboul-Fadl T, Bin-Jubair FA, Aboul-Wafa O.

Eur J Med Chem. 2010 Oct;45(10):4578-86. doi: 10.1016/j.ejmech.2010.07.020.

PMID:
20696500
14.
15.

Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1.

Trefzer C, Škovierová H, Buroni S, Bobovská A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikušová K, Johnsson K.

J Am Chem Soc. 2012 Jan 18;134(2):912-5. doi: 10.1021/ja211042r.

PMID:
22188377
16.

Identification, synthesis, and pharmacological evaluation of tetrahydroindazole based ligands as novel antituberculosis agents.

Guo S, Song Y, Huang Q, Yuan H, Wan B, Wang Y, He R, Beconi MG, Franzblau SG, Kozikowski AP.

J Med Chem. 2010 Jan 28;53(2):649-59. doi: 10.1021/jm901235p.

PMID:
20000470
17.

Design, synthesis, and pharmacological evaluation of mefloquine-based ligands as novel antituberculosis agents.

Mao J, Wang Y, Wan B, Kozikowski AP, Franzblau SG.

ChemMedChem. 2007 Nov;2(11):1624-30.

PMID:
17680579
18.

Structure-activity relationships for a series of quinoline-based compounds active against replicating and nonreplicating Mycobacterium tuberculosis.

Lilienkampf A, Mao J, Wan B, Wang Y, Franzblau SG, Kozikowski AP.

J Med Chem. 2009 Apr 9;52(7):2109-18. doi: 10.1021/jm900003c.

PMID:
19271749
19.

Synthesis of 1,3-thiazine derivatives and their evaluation as potential antimycobacterial agents.

Koketsu M, Tanaka K, Takenaka Y, Kwong CD, Ishihara H.

Eur J Pharm Sci. 2002 Apr;15(3):307-10.

PMID:
11923063
20.

1,4-diarylpiperazines and analogs as anti-tubercular agents: synthesis and biological evaluation.

Forge D, Cappoen D, Laurent J, Stanicki D, Mayence A, Huang TL, Verschaeve L, Huygen K, Vanden Eynde JJ.

Eur J Med Chem. 2012 Mar;49:95-101. doi: 10.1016/j.ejmech.2011.12.035.

PMID:
22301215
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