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IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas.

Greisman HA, Lu Z, Tsai AG, Greiner TC, Yi HS, Lieber MR.

Blood. 2012 Oct 4;120(14):2864-7. doi: 10.1182/blood-2012-02-412791. Epub 2012 Aug 20.


Identification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t(8;14) translocations in sporadic Burkitt-lymphoma.

Busch K, Keller T, Fuchs U, Yeh RF, Harbott J, Klose I, Wiemels J, Novosel A, Reiter A, Borkhardt A.

Leukemia. 2007 Aug;21(8):1739-51. Epub 2007 May 31.


BCL6 breaks occur at different AID sequence motifs in Ig-BCL6 and non-Ig-BCL6 rearrangements.

Lu Z, Tsai AG, Akasaka T, Ohno H, Jiang Y, Melnick AM, Greisman HA, Lieber MR.

Blood. 2013 May 30;121(22):4551-4. doi: 10.1182/blood-2012-10-464958. Epub 2013 Mar 8.


The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma.

Murga Penas EM, Callet-Bauchu E, Ye H, Gazzo S, Berger F, Schilling G, Albert-Konetzny N, Vettorazzi E, Salles G, Wlodarska I, Du MQ, Bokemeyer C, Dierlamm J.

Blood. 2010 Mar 18;115(11):2214-9. doi: 10.1182/blood-2009-08-236265. Epub 2009 Nov 25.


Variable breakpoints in Burkitt lymphoma cells with chromosomal t(8;14) translocation separate c-myc and the IgH locus up to several hundred kb.

Joos S, Falk MH, Lichter P, Haluska FG, Henglein B, Lenoir GM, Bornkamm GW.

Hum Mol Genet. 1992 Nov;1(8):625-32.


Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice.

Park SS, Kim JS, Tessarollo L, Owens JD, Peng L, Han SS, Tae Chung S, Torrey TA, Cheung WC, Polakiewicz RD, McNeil N, Ried T, Mushinski JF, Morse HC 3rd, Janz S.

Cancer Res. 2005 Feb 15;65(4):1306-15.


Templated nucleotide addition and immunoglobulin JH-gene utilization in t(11;14) junctions: implications for the mechanism of translocation and the origin of mantle cell lymphoma.

Welzel N, Le T, Marculescu R, Mitterbauer G, Chott A, Pott C, Kneba M, Du MQ, Kusec R, Drach J, Raderer M, Mannhalter C, Lechner K, Nadel B, Jaeger U.

Cancer Res. 2001 Feb 15;61(4):1629-36.


Mature B-cell leukemias with more than 55% prolymphocytes: report of 2 cases with Burkitt lymphoma-type chromosomal translocations involving c-myc.

Merchant S, Schlette E, Sanger W, Lai R, Medeiros LJ.

Arch Pathol Lab Med. 2003 Mar;127(3):305-9. Review.


Mantle cell lymphoma with 8q24 chromosomal abnormalities: a report of 5 cases with blastoid features.

Hao S, Sanger W, Onciu M, Lai R, Schlette EJ, Medeiros LJ.

Mod Pathol. 2002 Dec;15(12):1266-72. Review.


AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.

Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC.

Cell. 2008 Dec 12;135(6):1028-38. doi: 10.1016/j.cell.2008.09.062.


Derivative (14)t(11;14)(q13;q32)t(11;14)(p11.2;p11.2): a novel unbalanced variant of the t(11;14)(q13;q32) translocation in mantle cell lymphoma.

Sathanoori M, Shekhter-Levin S, Marks SM, Swerdlow SH.

Cancer Genet Cytogenet. 2007 Jan 15;172(2):158-64.


Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells.

Walker BA, Wardell CP, Johnson DC, Kaiser MF, Begum DB, Dahir NB, Ross FM, Davies FE, Gonzalez D, Morgan GJ.

Blood. 2013 Apr 25;121(17):3413-9. doi: 10.1182/blood-2012-12-471888. Epub 2013 Feb 22.


Role of the translocation partner in protection against AID-dependent chromosomal translocations.

Jankovic M, Robbiani DF, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, Nussenzweig A, Nussenzweig MC.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):187-92. doi: 10.1073/pnas.0908946107. Epub 2009 Dec 4.


Erroneous class switching and false VDJ recombination: molecular dissection of t(8;14)/MYC-IGH translocations in Burkitt-type lymphoblastic leukemia/B-cell lymphoma.

Burmeister T, Molkentin M, Schwartz S, Gökbuget N, Hoelzer D, Thiel E, Reinhardt R.

Mol Oncol. 2013 Aug;7(4):850-8. doi: 10.1016/j.molonc.2013.04.006. Epub 2013 Apr 25.


Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.

Hu J, Tepsuporn S, Meyers RM, Gostissa M, Alt FW.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10269-74. doi: 10.1073/pnas.1410112111. Epub 2014 Jun 30.


Mechanisms promoting translocations in editing and switching peripheral B cells.

Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW.

Nature. 2009 Jul 9;460(7252):231-6. doi: 10.1038/nature08159.


Molecular analysis of bcl-1/IgH junctional sequences in mantle cell lymphoma: potential mechanism of the t(11;14) chromosomal translocation.

Stamatopoulos K, Kosmas C, Belessi C, Kyriazopoulos P, Papadaki T, Anagnostou D, Loukopoulos D.

Br J Haematol. 1999 Apr;105(1):190-7.


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