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Toll-like receptor-4 signaling in mantle cell lymphoma: effects on tumor growth and immune evasion.

Wang L, Zhao Y, Qian J, Sun L, Lu Y, Li H, Li Y, Yang J, Cai Z, Yi Q.

Cancer. 2013 Feb 15;119(4):782-91. doi: 10.1002/cncr.27792. Epub 2012 Aug 22.


Triggering of Toll-like receptor 4 expressed on human head and neck squamous cell carcinoma promotes tumor development and protects the tumor from immune attack.

Szczepanski MJ, Czystowska M, Szajnik M, Harasymczuk M, Boyiadzis M, Kruk-Zagajewska A, Szyfter W, Zeromski J, Whiteside TL.

Cancer Res. 2009 Apr 1;69(7):3105-13. doi: 10.1158/0008-5472.CAN-08-3838. Epub 2009 Mar 24.


Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells.

Li X, Tupper JC, Bannerman DD, Winn RK, Rhodes CJ, Harlan JM.

Infect Immun. 2003 Aug;71(8):4414-20.


Toll-Like Receptor 1/2 and 5 Ligands Enhance the Expression of Cyclin D1 and D3 and Induce Proliferation in Mantle Cell Lymphoma.

Mastorci K, Muraro E, Pasini E, Furlan C, Sigalotti L, Cinco M, Dolcetti R, Fratta E.

PLoS One. 2016 Apr 28;11(4):e0153823. doi: 10.1371/journal.pone.0153823. eCollection 2016.


TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer.

Szajnik M, Szczepanski MJ, Czystowska M, Elishaev E, Mandapathil M, Nowak-Markwitz E, Spaczynski M, Whiteside TL.

Oncogene. 2009 Dec 10;28(49):4353-63. doi: 10.1038/onc.2009.289.


Bacterial lipopolysaccharide induces increased expression of toll-like receptor (TLR) 4 and downstream TLR signaling molecules in bovine mammary epithelial cells.

Ibeagha-Awemu EM, Lee JW, Ibeagha AE, Bannerman DD, Paape MJ, Zhao X.

Vet Res. 2008 Mar-Apr;39(2):11. Epub 2007 Dec 21.


Role of toll-like receptor 4 on the immune escape of human oral squamous cell carcinoma and resistance of cisplatin-induced apoptosis.

Sun Z, Luo Q, Ye D, Chen W, Chen F.

Mol Cancer. 2012 May 14;11:33. doi: 10.1186/1476-4598-11-33.


Functional Toll-like receptor 4 expressed in lactotrophs mediates LPS-induced proliferation in experimental pituitary hyperplasia.

Sabatino ME, Sosa Ldel V, Petiti JP, Mukdsi JH, Mascanfroni ID, Pellizas CG, Gutiérrez S, Torres AI, De Paul AL.

Exp Cell Res. 2013 Nov 15;319(19):3020-34. doi: 10.1016/j.yexcr.2013.08.012. Epub 2013 Aug 20.


Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways.

Gorina R, Font-Nieves M, Márquez-Kisinousky L, Santalucia T, Planas AM.

Glia. 2011 Feb;59(2):242-55. doi: 10.1002/glia.21094.


The scaffold MyD88 acts to couple protein kinase Cepsilon to Toll-like receptors.

Faisal A, Saurin A, Gregory B, Foxwell B, Parker PJ.

J Biol Chem. 2008 Jul 4;283(27):18591-600. doi: 10.1074/jbc.M710330200. Epub 2008 May 5.


Human intrahepatic biliary epithelial cells function in innate immunity by producing IL-6 and IL-8 via the TLR4-NF-kappaB and -MAPK signaling pathways.

Yokoyama T, Komori A, Nakamura M, Takii Y, Kamihira T, Shimoda S, Mori T, Fujiwara S, Koyabu M, Taniguchi K, Fujioka H, Migita K, Yatsuhashi H, Ishibashi H.

Liver Int. 2006 May;26(4):467-76.


Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells.

Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX, Song LH.

J Pineal Res. 2012 Nov;53(4):325-34. doi: 10.1111/j.1600-079X.2012.01002.x. Epub 2012 Apr 27.


Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling.

Bretz NP, Ridinger J, Rupp AK, Rimbach K, Keller S, Rupp C, Marmé F, Umansky L, Umansky V, Eigenbrod T, Sammar M, Altevogt P.

J Biol Chem. 2013 Dec 20;288(51):36691-702. doi: 10.1074/jbc.M113.512806. Epub 2013 Nov 13.


Heterotrimeric Gi/Go proteins modulate endothelial TLR signaling independent of the MyD88-dependent pathway.

Dauphinee SM, Voelcker V, Tebaykina Z, Wong F, Karsan A.

Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2246-53. doi: 10.1152/ajpheart.01194.2010. Epub 2011 Sep 23.


Regulation of Toll-like receptor 4-induced proasthmatic changes in airway smooth muscle function by opposing actions of ERK1/2 and p38 MAPK signaling.

Shan X, Hu A, Veler H, Fatma S, Grunstein JS, Chuang S, Grunstein MM.

Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L324-33. Epub 2006 Mar 31.


Toll-like receptors on tumor cells facilitate evasion of immune surveillance.

Huang B, Zhao J, Li H, He KL, Chen Y, Chen SH, Mayer L, Unkeless JC, Xiong H.

Cancer Res. 2005 Jun 15;65(12):5009-14. Erratum in: Cancer Res. 2005 Oct 1;65(19):9108. Chen, Shu-Hsia [added].


Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage.

Lin S, Yin Q, Zhong Q, Lv FL, Zhou Y, Li JQ, Wang JZ, Su BY, Yang QW.

J Neuroinflammation. 2012 Mar 6;9:46. doi: 10.1186/1742-2094-9-46.


LPS induces IL-8 expression through TLR4, MyD88, NF-kappaB and MAPK pathways in human dental pulp stem cells.

He W, Qu T, Yu Q, Wang Z, Lv H, Zhang J, Zhao X, Wang P.

Int Endod J. 2013 Feb;46(2):128-36. doi: 10.1111/j.1365-2591.2012.02096.x. Epub 2012 Jul 12.


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