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Items: 1 to 20 of 93

1.

Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice.

Møllersen L, Rowe AD, Illuzzi JL, Hildrestrand GA, Gerhold KJ, Tveterås L, Bjølgerud A, Wilson DM 3rd, Bjørås M, Klungland A.

Hum Mol Genet. 2012 Nov 15;21(22):4939-47. doi: 10.1093/hmg/dds337. Epub 2012 Aug 21.

2.

Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.

Goula AV, Berquist BR, Wilson DM 3rd, Wheeler VC, Trottier Y, Merienne K.

PLoS Genet. 2009 Dec;5(12):e1000749. doi: 10.1371/journal.pgen.1000749. Epub 2009 Dec 4.

3.

Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice.

Larson E, Fyfe I, Morton AJ, Monckton DG.

Neurobiol Dis. 2015 Apr;76:98-111. doi: 10.1016/j.nbd.2015.01.004. Epub 2015 Feb 3.

PMID:
25662336
4.

Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice.

Møllersen L, Moldestad O, Rowe AD, Bjølgerud A, Holm I, Tveterås L, Klungland A, Retterstøl L.

PLoS Curr. 2016 Jul 5;8. pii: ecurrents.hd.58d04209ab6d5de0844db7ef5628ff67. doi: 10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67.

5.

Transcription elongation and tissue-specific somatic CAG instability.

Goula AV, Stys A, Chan JP, Trottier Y, Festenstein R, Merienne K.

PLoS Genet. 2012;8(11):e1003051. doi: 10.1371/journal.pgen.1003051. Epub 2012 Nov 29.

6.

MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice.

Tomé S, Manley K, Simard JP, Clark GW, Slean MM, Swami M, Shelbourne PF, Tillier ER, Monckton DG, Messer A, Pearson CE.

PLoS Genet. 2013;9(2):e1003280. doi: 10.1371/journal.pgen.1003280. Epub 2013 Feb 28.

7.

Continuous and periodic expansion of CAG repeats in Huntington's disease R6/1 mice.

Møllersen L, Rowe AD, Larsen E, Rognes T, Klungland A.

PLoS Genet. 2010 Dec 9;6(12):e1001242. doi: 10.1371/journal.pgen.1001242.

8.

Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.

Pinto RM, Dragileva E, Kirby A, Lloret A, Lopez E, St Claire J, Panigrahi GB, Hou C, Holloway K, Gillis T, Guide JR, Cohen PE, Li GM, Pearson CE, Daly MJ, Wheeler VC.

PLoS Genet. 2013 Oct;9(10):e1003930. doi: 10.1371/journal.pgen.1003930. Epub 2013 Oct 31.

9.

Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability.

Cilli P, Ventura I, Minoprio A, Meccia E, Martire A, Wilson SH, Bignami M, Mazzei F.

Nucleic Acids Res. 2016 Jun 20;44(11):5190-203. doi: 10.1093/nar/gkw170. Epub 2016 Mar 14.

10.

Cockayne syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo.

Kovtun IV, Johnson KO, McMurray CT.

Aging (Albany NY). 2011 May;3(5):509-14.

11.

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.

Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, McMurray CT.

Nature. 2007 May 24;447(7143):447-52. Epub 2007 Apr 22.

12.

Verification of somatic CAG repeat expansion by pre-PCR fractionation.

Hunter JM, Crouse AB, Lesort M, Johnson GV, Detloff PJ.

J Neurosci Methods. 2005 May 15;144(1):11-7. Epub 2004 Nov 28.

PMID:
15848234
13.

Nucleotide excision repair and the 26S proteasome function together to promote trinucleotide repeat expansions.

Concannon C, Lahue RS.

DNA Repair (Amst). 2014 Jan;13:42-9. doi: 10.1016/j.dnarep.2013.11.004. Epub 2013 Dec 17.

PMID:
24359926
14.

Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset.

Vatsavayai SC, Dallérac GM, Milnerwood AJ, Cummings DM, Rezaie P, Murphy KP, Hirst MC.

Brain Res Bull. 2007 Apr 30;72(2-3):98-102. Epub 2006 Nov 13.

PMID:
17352932
15.

Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease.

Budworth H, Harris FR, Williams P, Lee DY, Holt A, Pahnke J, Szczesny B, Acevedo-Torres K, Ayala-Peña S, McMurray CT.

PLoS Genet. 2015 Aug 6;11(8):e1005267. doi: 10.1371/journal.pgen.1005267. eCollection 2015 Aug.

16.

Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.

Hubert L Jr, Lin Y, Dion V, Wilson JH.

Hum Mol Genet. 2011 Dec 15;20(24):4822-30. doi: 10.1093/hmg/ddr421. Epub 2011 Sep 15.

17.

Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset.

Swami M, Hendricks AE, Gillis T, Massood T, Mysore J, Myers RH, Wheeler VC.

Hum Mol Genet. 2009 Aug 15;18(16):3039-47. doi: 10.1093/hmg/ddp242. Epub 2009 May 23.

18.

Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington's disease gene.

Ishiguro H, Yamada K, Sawada H, Nishii K, Ichino N, Sawada M, Kurosawa Y, Matsushita N, Kobayashi K, Goto J, Hashida H, Masuda N, Kanazawa I, Nagatsu T.

J Neurosci Res. 2001 Aug 15;65(4):289-97.

PMID:
11494364
19.

Gender of the embryo contributes to CAG instability in transgenic mice containing a Huntington's disease gene.

Kovtun IV, Therneau TM, McMurray CT.

Hum Mol Genet. 2000 Nov 1;9(18):2767-75.

PMID:
11063736
20.

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice.

Manley K, Shirley TL, Flaherty L, Messer A.

Nat Genet. 1999 Dec;23(4):471-3.

PMID:
10581038

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