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Items: 1 to 20 of 150

1.

Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice.

Anea CB, Cheng B, Sharma S, Kumar S, Caldwell RW, Yao L, Ali MI, Merloiu AM, Stepp DW, Black SM, Fulton DJ, Rudic RD.

Circ Res. 2012 Oct 12;111(9):1157-65. doi: 10.1161/CIRCRESAHA.111.261750. Epub 2012 Aug 20.

2.

Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells.

Sugiyama T, Levy BD, Michel T.

J Biol Chem. 2009 May 8;284(19):12691-700. doi: 10.1074/jbc.M809295200. Epub 2009 Mar 12.

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Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling.

Schmidt K, Kolesnik B, Gorren AC, Werner ER, Mayer B.

Biochem Pharmacol. 2014 Aug 1;90(3):246-53. doi: 10.1016/j.bcp.2014.05.010. Epub 2014 May 24.

5.

CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.

Ali ZA, Bursill CA, Douglas G, McNeill E, Papaspyridonos M, Tatham AL, Bendall JK, Akhtar AM, Alp NJ, Greaves DR, Channon KM.

Circulation. 2008 Sep 30;118(14 Suppl):S71-7. doi: 10.1161/CIRCULATIONAHA.107.753558.

6.

Circadian clock control of Nox4 and reactive oxygen species in the vasculature.

Anea CB, Zhang M, Chen F, Ali MI, Hart CM, Stepp DW, Kovalenkov YO, Merloiu AM, Pati P, Fulton D, Rudic RD.

PLoS One. 2013 Oct 25;8(10):e78626. doi: 10.1371/journal.pone.0078626. eCollection 2013.

7.

Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice.

d'Uscio LV, Smith LA, Katusic ZS.

Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2227-34. doi: 10.1152/ajpheart.00588.2011. Epub 2011 Sep 30.

8.

Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice.

Xia N, Daiber A, Habermeier A, Closs EI, Thum T, Spanier G, Lu Q, Oelze M, Torzewski M, Lackner KJ, Münzel T, Förstermann U, Li H.

J Pharmacol Exp Ther. 2010 Oct;335(1):149-54. doi: 10.1124/jpet.110.168724. Epub 2010 Jul 7.

9.

A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression.

Takaya T, Hirata K, Yamashita T, Shinohara M, Sasaki N, Inoue N, Yada T, Goto M, Fukatsu A, Hayashi T, Alp NJ, Channon KM, Yokoyama M, Kawashima S.

Arterioscler Thromb Vasc Biol. 2007 Jul;27(7):1632-7. Epub 2007 Apr 26.

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11.

Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene.

d'Uscio LV, He T, Santhanam AV, Tai LJ, Evans RM, Katusic ZS.

Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H1001-10. doi: 10.1152/ajpheart.00761.2013. Epub 2014 Jan 31.

12.

eNOS uncoupling and endothelial dysfunction in aged vessels.

Yang YM, Huang A, Kaley G, Sun D.

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1829-36. doi: 10.1152/ajpheart.00230.2009. Epub 2009 Sep 18.

13.

Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus.

Sasaki N, Yamashita T, Takaya T, Shinohara M, Shiraki R, Takeda M, Emoto N, Fukatsu A, Hayashi T, Ikemoto K, Nomura T, Yokoyama M, Hirata K, Kawashima S.

Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1068-76. doi: 10.1161/ATVBAHA.107.160754. Epub 2008 Apr 10.

14.

Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.

d'Uscio LV, Das P, Santhanam AV, He T, Younkin SG, Katusic ZS.

Cardiovasc Res. 2012 Dec 1;96(3):504-12. doi: 10.1093/cvr/cvs266. Epub 2012 Aug 10.

15.

Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice.

Santhanam AV, d'Uscio LV, He T, Das P, Younkin SG, Katusic ZS.

J Neurochem. 2015 Sep;134(6):1129-38. doi: 10.1111/jnc.13205. Epub 2015 Jul 15.

16.
17.

Differential Regulation of BMAL1, CLOCK, and Endothelial Signaling in the Aortic Arch and Ligated Common Carotid Artery.

Shang X, Pati P, Anea CB, Fulton DJ, Rudic RD.

J Vasc Res. 2016;53(5-6):269-278. doi: 10.1159/000452410. Epub 2016 Dec 7.

18.

Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926.

Zhou ZW, Xie XL, Zhou SF, Li CG.

Eur J Pharmacol. 2012 Dec 15;697(1-3):97-105. doi: 10.1016/j.ejphar.2012.09.051. Epub 2012 Oct 11.

PMID:
23063542
19.

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling.

Antoniades C, Bakogiannis C, Leeson P, Guzik TJ, Zhang MH, Tousoulis D, Antonopoulos AS, Demosthenous M, Marinou K, Hale A, Paschalis A, Psarros C, Triantafyllou C, Bendall J, Casadei B, Stefanadis C, Channon KM.

Circulation. 2011 Jul 19;124(3):335-45. doi: 10.1161/CIRCULATIONAHA.110.985150. Epub 2011 Jul 5.

20.

Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin.

Laursen JB, Somers M, Kurz S, McCann L, Warnholtz A, Freeman BA, Tarpey M, Fukai T, Harrison DG.

Circulation. 2001 Mar 6;103(9):1282-8.

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