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Items: 1 to 20 of 324

1.

Periostin facilitates skin sclerosis via PI3K/Akt dependent mechanism in a mouse model of scleroderma.

Yang L, Serada S, Fujimoto M, Terao M, Kotobuki Y, Kitaba S, Matsui S, Kudo A, Naka T, Murota H, Katayama I.

PLoS One. 2012;7(7):e41994. doi: 10.1371/journal.pone.0041994.

PMID:
22911870
2.

Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model.

Stegemann A, Sindrilaru A, Eckes B, del Rey A, Heinick A, Schulte JS, Müller FU, Grando SA, Fiebich BL, Scharffetter-Kochanek K, Luger TA, Böhm M.

Arthritis Rheum. 2013 Mar;65(3):792-804. doi: 10.1002/art.37809.

PMID:
23440693
3.

CD109 overexpression ameliorates skin fibrosis in a mouse model of bleomycin-induced scleroderma.

Vorstenbosch J, Al-Ajmi H, Winocour S, Trzeciak A, Lessard L, Philip A.

Arthritis Rheum. 2013 May;65(5):1378-83. doi: 10.1002/art.37907.

PMID:
23436317
4.
5.

UVA irradiation following treatment with topical 8-methoxypsoralen improves bleomycin-induced scleroderma in a mouse model, by reducing the collagen content and collagen gene expression levels in the skin.

Hayashi S, Ikeda M, Kitamura Y, Hamasaki Y, Hatamochi A.

J Dermatol Sci. 2012 Jul;67(1):20-5. doi: 10.1016/j.jdermsci.2012.02.013.

PMID:
22486844
6.

Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis.

Kapoor M, McCann M, Liu S, Huh K, Denton CP, Abraham DJ, Leask A.

Arthritis Rheum. 2009 Sep;60(9):2822-9. doi: 10.1002/art.24761.

PMID:
19714649
7.

A convenient method for producing the bleomycin-induced mouse model of scleroderma by weekly injections using a methylcellulose gel.

Jun JB, Kim JK, Na YI, Jang SM, Paik SS, Kim YH.

Rheumatol Int. 2012 May;32(5):1443-7. doi: 10.1007/s00296-011-1884-0.

PMID:
21448642
8.

Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis.

Reich N, Tomcik M, Zerr P, Lang V, Dees C, Avouac J, Palumbo K, Horn A, Akhmetshina A, Beyer C, Xie W, Bennett BL, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2012 May;71(5):737-45. doi: 10.1136/annrheumdis-2011-200412.

PMID:
22258492
9.

Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor beta.

Bhattacharyya S, Ghosh AK, Pannu J, Mori Y, Takagawa S, Chen G, Trojanowska M, Gilliam AC, Varga J.

Arthritis Rheum. 2005 Apr;52(4):1248-58.

PMID:
15818659
10.

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl GE.

Arthritis Rheum. 2009 Jul;60(7):2142-55. doi: 10.1002/art.24620.

PMID:
19565505
11.

Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model.

Liu S, Kapoor M, Denton CP, Abraham DJ, Leask A.

Arthritis Rheum. 2009 Sep;60(9):2817-21. doi: 10.1002/art.24801.

PMID:
19714619
12.

Serum periostin levels are correlated with progressive skin sclerosis in patients with systemic sclerosis.

Yamaguchi Y, Ono J, Masuoka M, Ohta S, Izuhara K, Ikezawa Z, Aihara M, Takahashi K.

Br J Dermatol. 2013 Apr;168(4):717-25. doi: 10.1111/bjd.12117.

PMID:
23110679
13.

Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.

Avouac J, Palumbo K, Tomcik M, Zerr P, Dees C, Horn A, Maurer B, Akhmetshina A, Beyer C, Sadowski A, Schneider H, Shiozawa S, Distler O, Schett G, Allanore Y, Distler JH.

Arthritis Rheum. 2012 May;64(5):1642-52. doi: 10.1002/art.33501.

PMID:
22139817
14.

Sequential analysis of myofibroblast differentiation and transforming growth factor-β1/Smad pathway activation in murine pulmonary fibrosis.

Usuki J, Matsuda K, Azuma A, Kudoh S, Gemma A.

J Nippon Med Sch. 2012;79(1):46-59.

PMID:
22398790
15.

Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors.

Kawaguchi Y, Takagi K, Hara M, Fukasawa C, Sugiura T, Nishimagi E, Harigai M, Kamatani N.

Arthritis Rheum. 2004 Jan;50(1):216-26.

PMID:
14730619
16.

Disruption of tumor necrosis factor receptor p55 impairs collagen turnover in experimentally induced sclerodermic skin fibroblasts.

Murota H, Hamasaki Y, Nakashima T, Yamamoto K, Katayama I, Matsuyama T.

Arthritis Rheum. 2003 Apr;48(4):1117-25.

PMID:
12687556
17.

Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis.

Huber LC, Distler JH, Moritz F, Hemmatazad H, Hauser T, Michel BA, Gay RE, Matucci-Cerinic M, Gay S, Distler O, Jüngel A.

Arthritis Rheum. 2007 Aug;56(8):2755-64.

PMID:
17665426
18.

Plasminogen activator inhibitor-1 is elevated, but not essential, in the development of bleomycin-induced murine scleroderma.

Matsushita M, Yamamoto T, Nishioka K.

Clin Exp Immunol. 2005 Mar;139(3):429-38.

PMID:
15730388
19.

Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis.

Yoshizaki A, Yanaba K, Yoshizaki A, Iwata Y, Komura K, Ogawa F, Takenaka M, Shimizu K, Asano Y, Hasegawa M, Fujimoto M, Sato S.

Arthritis Rheum. 2010 Aug;62(8):2476-87. doi: 10.1002/art.27498.

PMID:
20506342
20.

Vertical inhibition of PI3K/Akt/mTOR signaling demonstrates in vitro and in vivo anti-fibrotic activity.

Liang M, Lv J, Chu H, Wang J, Chen X, Zhu X, Xue Y, Guan M, Zou H.

J Dermatol Sci. 2014 Nov;76(2):104-11. doi: 10.1016/j.jdermsci.2014.08.002.

PMID:
25258031
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