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Identification of a novel LXXLL motif in α-actinin 4-spliced isoform that is critical for its interaction with estrogen receptor α and co-activators.

Khurana S, Chakraborty S, Zhao X, Liu Y, Guan D, Lam M, Huang W, Yang S, Kao HY.

J Biol Chem. 2012 Oct 12;287(42):35418-29. doi: 10.1074/jbc.M112.401364. Epub 2012 Aug 20.


The actin-binding protein, actinin alpha 4 (ACTN4), is a nuclear receptor coactivator that promotes proliferation of MCF-7 breast cancer cells.

Khurana S, Chakraborty S, Cheng X, Su YT, Kao HY.

J Biol Chem. 2011 Jan 21;286(3):1850-9. doi: 10.1074/jbc.M110.162107. Epub 2010 Nov 15.


α Actinin 4 (ACTN4) Regulates Glucocorticoid Receptor-mediated Transactivation and Transrepression in Podocytes.

Zhao X, Khurana S, Charkraborty S, Tian Y, Sedor JR, Bruggman LA, Kao HY.

J Biol Chem. 2017 Feb 3;292(5):1637-1647. doi: 10.1074/jbc.M116.755546. Epub 2016 Dec 20.


[Novel splicing isoform of actin-binding protein alpha-actinin 4 in epidermoid carcinoma cells A431].

Aksenova VIu, Khotin MG, Turoverova LV, Iudintseva NM, Magnusson KÉ, Pinaev GP, Tentler DG.

Tsitologiia. 2012;54(1):25-32. Russian.


Binding of the ERα and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen- and dioxin-related transcription.

Endler A, Chen L, Zhang J, Xu GT, Shibasaki F.

J Cell Sci. 2012 Apr 15;125(Pt 8):2004-16. doi: 10.1242/jcs.097246. Epub 2012 Feb 10.


Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors.

Khurana S, Chakraborty S, Lam M, Liu Y, Su YT, Zhao X, Saleem MA, Mathieson PW, Bruggeman LA, Kao HY.

J Biol Chem. 2012 Apr 6;287(15):12027-35. doi: 10.1074/jbc.M112.345421. Epub 2012 Feb 17.


α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function.

Zhao X, Hsu KS, Lim JH, Bruggeman LA, Kao HY.

J Biol Chem. 2015 Jan 2;290(1):338-49. doi: 10.1074/jbc.M114.597260. Epub 2014 Nov 19.


Phosphorylation of alpha-actinin 4 upon epidermal growth factor exposure regulates its interaction with actin.

Shao H, Wu C, Wells A.

J Biol Chem. 2010 Jan 22;285(4):2591-600. doi: 10.1074/jbc.M109.035790. Epub 2009 Nov 17.


Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB.

Aksenova V, Turoverova L, Khotin M, Magnusson KE, Tulchinsky E, Melino G, Pinaev GP, Barlev N, Tentler D.

Oncotarget. 2013 Feb;4(2):362-72.


Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta.

Chang Cy, Norris JD, Grøn H, Paige LA, Hamilton PT, Kenan DJ, Fowlkes D, McDonnell DP.

Mol Cell Biol. 1999 Dec;19(12):8226-39.


Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors.

Klinge CM, Jernigan SC, Mattingly KA, Risinger KE, Zhang J.

J Mol Endocrinol. 2004 Oct;33(2):387-410.


Ligand-independent activation of estrogen receptor alpha by XBP-1.

Ding L, Yan J, Zhu J, Zhong H, Lu Q, Wang Z, Huang C, Ye Q.

Nucleic Acids Res. 2003 Sep 15;31(18):5266-74.


Core LXXLL motif sequences in CREB-binding protein, SRC1, and RIP140 define affinity and selectivity for steroid and retinoid receptors.

Heery DM, Hoare S, Hussain S, Parker MG, Sheppard H.

J Biol Chem. 2001 Mar 2;276(9):6695-702. Epub 2000 Nov 14.


Characterization of steroid receptor coactivator in sea urchin, Strongylocentrotus nudus, and its involvement in embryonic development.

Kim MA, Kim GJ, Maeng S, Jin DH, Sohn YC.

Mol Cell Endocrinol. 2011 Jan 1;331(1):89-101. doi: 10.1016/j.mce.2010.08.013. Epub 2010 Sep 15.


Estrogen receptor-alpha interaction with the CREB binding protein coactivator is regulated by the cellular environment.

Jaber BM, Mukopadhyay R, Smith CL.

J Mol Endocrinol. 2004 Feb;32(1):307-23.


The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.

Nikolopoulos SN, Spengler BA, Kisselbach K, Evans AE, Biedler JL, Ross RA.

Oncogene. 2000 Jan 20;19(3):380-6.


α-actinin-4 is essential for maintaining the spreading, motility and contractility of fibroblasts.

Shao H, Wang JH, Pollak MR, Wells A.

PLoS One. 2010 Nov 11;5(11):e13921. doi: 10.1371/journal.pone.0013921.


The enhancement of nuclear receptor transcriptional activation by a mouse actin-binding protein, alpha actinin 2.

Huang SM, Huang CJ, Wang WM, Kang JC, Hsu WC.

J Mol Endocrinol. 2004 Apr;32(2):481-96.


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