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Lipopolysaccharide potentiates polychlorinated biphenyl-induced disruption of the blood-brain barrier via TLR4/IRF-3 signaling.

Choi JJ, Choi YJ, Chen L, Zhang B, Eum SY, Abreu MT, Toborek M.

Toxicology. 2012 Dec 16;302(2-3):212-20. doi: 10.1016/j.tox.2012.08.001. Epub 2012 Aug 13.


Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression.

Choi YJ, Seelbach MJ, Pu H, Eum SY, Chen L, Zhang B, Hennig B, Toborek M.

Environ Health Perspect. 2010 Jul;118(7):976-81. doi: 10.1289/ehp.0901751. Epub 2010 Mar 18.


Polychlorinated biphenyls disrupt blood-brain barrier integrity and promote brain metastasis formation.

Seelbach M, Chen L, Powell A, Choi YJ, Zhang B, Hennig B, Toborek M.

Environ Health Perspect. 2010 Apr;118(4):479-84. doi: 10.1289/ehp.0901334. Epub 2009 Oct 28.


TLR4 signaling is involved in brain vascular toxicity of PCB153 bound to nanoparticles.

Zhang B, Choi JJ, Eum SY, Daunert S, Toborek M.

PLoS One. 2013 May 14;8(5):e63159. doi: 10.1371/journal.pone.0063159. Print 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/e34adc2a-f73a-4055-8519-fa2deb2e852f.


Cerebrovascular toxicity of PCB153 is enhanced by binding to silica nanoparticles.

Zhang B, Chen L, Choi JJ, Hennig B, Toborek M.

J Neuroimmune Pharmacol. 2012 Dec;7(4):991-1001. doi: 10.1007/s11481-012-9403-y. Epub 2012 Oct 19.


Lipid rafts regulate PCB153-induced disruption of occludin and brain endothelial barrier function through protein phosphatase 2A and matrix metalloproteinase-2.

Eum SY, Jaraki D, András IE, Toborek M.

Toxicol Appl Pharmacol. 2015 Sep 15;287(3):258-66. doi: 10.1016/j.taap.2015.06.011. Epub 2015 Jun 14.


Proinflammatory adhesion molecules facilitate polychlorinated biphenyl-mediated enhancement of brain metastasis formation.

Sipos E, Chen L, András IE, Wrobel J, Zhang B, Pu H, Park M, Eum SY, Toborek M.

Toxicol Sci. 2012 Apr;126(2):362-71. doi: 10.1093/toxsci/kfr349. Epub 2012 Jan 12.


Polychlorinated Biphenyls (PCB 101, 153, and 180) Impair Murine Macrophage Responsiveness to Lipopolysaccharide: Involvement of NF-κB Pathway.

Santoro A, Ferrante MC, Di Guida F, Pirozzi C, Lama A, Simeoli R, Clausi MT, Monnolo A, Mollica MP, Mattace Raso G, Meli R.

Toxicol Sci. 2015 Sep;147(1):255-69. doi: 10.1093/toxsci/kfv127. Epub 2015 Jul 3.


LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury.

Vartanian KB, Stevens SL, Marsh BJ, Williams-Karnesky R, Lessov NS, Stenzel-Poore MP.

J Neuroinflammation. 2011 Oct 14;8:140. doi: 10.1186/1742-2094-8-140.


Modulation of cytokine gene expression by cathelicidin BMAP-28 in LPS-stimulated and -unstimulated macrophages.

D'Este F, Tomasinsig L, Skerlavaj B, Zanetti M.

Immunobiology. 2012 Oct;217(10):962-71. doi: 10.1016/j.imbio.2012.01.010. Epub 2012 Jan 13.


Lrg participates in lipopolysaccharide preconditioning-induced brain ischemia injury via TLR4 signaling pathway.

Gong G, Bai S, Wu W, Hu L, Liu Y, Niu J, Dai X, Yin L, Wang X.

J Mol Neurosci. 2014 Sep;54(1):20-6. doi: 10.1007/s12031-014-0240-8. Epub 2014 Feb 15.


Intracellular expression of toll-like receptor 4 in neuroblastoma cells and their unresponsiveness to lipopolysaccharide.

Hassan F, Islam S, Tumurkhuu G, Naiki Y, Koide N, Mori I, Yoshida T, Yokochi T.

BMC Cancer. 2006 Dec 8;6:281.


Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.

Piao W, Song C, Chen H, Diaz MA, Wahl LM, Fitzgerald KA, Li L, Medvedev AE.

J Leukoc Biol. 2009 Oct;86(4):863-75. doi: 10.1189/jlb.0309189. Epub 2009 Aug 5.


The Fab Fragment of a Humanized Anti-Toll Like Receptor 4 (TLR4) Monoclonal Antibody Reduces the Lipopolysaccharide Response via TLR4 in Mouse Macrophage.

Cai B, Wang M, Zhu X, Xu J, Zheng W, Zhang Y, Zheng F, Feng Z, Zhu J.

Int J Mol Sci. 2015 Oct 23;16(10):25502-15. doi: 10.3390/ijms161025502.


[Unfractionated heparin inhibits lipopolysaccharide-induced expression of granulocyte colony-stimulating factor in human endothelial cells through Toll-like receptor 4 signaling pathway].

Li X, Liu Y, Ma X.

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Feb;27(2):81-5. doi: 10.3760/cma.j.issn.2095-4352.2015.02.001. Chinese.


Sevoflurane inhibits nuclear factor-κB activation in lipopolysaccharide-induced acute inflammatory lung injury via toll-like receptor 4 signaling.

Sun XJ, Li XQ, Wang XL, Tan WF, Wang JK.

PLoS One. 2015 Apr 14;10(4):e0122752. doi: 10.1371/journal.pone.0122752. eCollection 2015.


Polychlorinated biphenyl-induced VCAM-1 expression is attenuated in aortic endothelial cells isolated from caveolin-1 deficient mice.

Han SG, Eum SY, Toborek M, Smart E, Hennig B.

Toxicol Appl Pharmacol. 2010 Jul;246(1-2):74-82. doi: 10.1016/j.taap.2010.04.009. Epub 2010 Apr 18.


Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway.

Harari OA, Alcaide P, Ahl D, Luscinskas FW, Liao JK.

Circ Res. 2006 May 12;98(9):1134-40. Epub 2006 Mar 30.


Somatostatin preserved blood brain barrier against cytokine induced alterations: possible role in multiple sclerosis.

Basivireddy J, Somvanshi RK, Romero IA, Weksler BB, Couraud PO, Oger J, Kumar U.

Biochem Pharmacol. 2013 Aug 15;86(4):497-507. doi: 10.1016/j.bcp.2013.06.001. Epub 2013 Jun 13.


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