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Items: 1 to 20 of 155

1.

Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic β-cells.

Alam MR, Groschner LN, Parichatikanond W, Kuo L, Bondarenko AI, Rost R, Waldeck-Weiermair M, Malli R, Graier WF.

J Biol Chem. 2012 Oct 5;287(41):34445-54. doi: 10.1074/jbc.M112.392084. Epub 2012 Aug 17.

2.

Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells.

Quan X, Nguyen TT, Choi SK, Xu S, Das R, Cha SK, Kim N, Han J, Wiederkehr A, Wollheim CB, Park KS.

J Biol Chem. 2015 Feb 13;290(7):4086-96. doi: 10.1074/jbc.M114.632547. Epub 2014 Dec 29.

3.

Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways.

Waldeck-Weiermair M, Jean-Quartier C, Rost R, Khan MJ, Vishnu N, Bondarenko AI, Imamura H, Malli R, Graier WF.

J Biol Chem. 2011 Aug 12;286(32):28444-55. doi: 10.1074/jbc.M111.244517. Epub 2011 May 25.

4.

Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.).

Waldeck-Weiermair M, Malli R, Parichatikanond W, Gottschalk B, Madreiter-Sokolowski CT, Klec C, Rost R, Graier WF.

Sci Rep. 2015 Oct 22;5:15602. doi: 10.1038/srep15602.

5.

MICU1 motifs define mitochondrial calcium uniporter binding and activity.

Hoffman NE, Chandramoorthy HC, Shamugapriya S, Zhang X, Rajan S, Mallilankaraman K, Gandhirajan RK, Vagnozzi RJ, Ferrer LM, Sreekrishnanilayam K, Natarajaseenivasan K, Vallem S, Force T, Choi ET, Cheung JY, Madesh M.

Cell Rep. 2013 Dec 26;5(6):1576-1588. doi: 10.1016/j.celrep.2013.11.026. Epub 2013 Dec 12.

6.

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.

Mallilankaraman K, Cárdenas C, Doonan PJ, Chandramoorthy HC, Irrinki KM, Golenár T, Csordás G, Madireddi P, Yang J, Müller M, Miller R, Kolesar JE, Molgó J, Kaufman B, Hajnóczky G, Foskett JK, Madesh M.

Nat Cell Biol. 2012 Dec;14(12):1336-43. doi: 10.1038/ncb2622. Epub 2012 Nov 25. Erratum in: Nat Cell Biol. 2015 Jul;17(7):953. Nat Cell Biol. 2013 Jan;15(1):123.

7.

Dynamics of mitochondrial Ca2+ uptake in MICU1-knockdown cells.

de la Fuente S, Matesanz-Isabel J, Fonteriz RI, Montero M, Alvarez J.

Biochem J. 2014 Feb 15;458(1):33-40. doi: 10.1042/BJ20131025.

PMID:
24313810
8.

Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival.

Hall DD, Wu Y, Domann FE, Spitz DR, Anderson ME.

PLoS One. 2014 May 6;9(5):e96866. doi: 10.1371/journal.pone.0096866. eCollection 2014.

9.

Impaired expression of the mitochondrial calcium uniporter suppresses mast cell degranulation.

Furuno T, Shinkai N, Inoh Y, Nakanishi M.

Mol Cell Biochem. 2015 Dec;410(1-2):215-21. doi: 10.1007/s11010-015-2554-4. Epub 2015 Sep 8.

PMID:
26350567
10.

Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake.

Matesanz-Isabel J, Arias-del-Val J, Alvarez-Illera P, Fonteriz RI, Montero M, Alvarez J.

Biochim Biophys Acta. 2016 Jun;1858(6):1110-7. doi: 10.1016/j.bbamem.2016.02.022. Epub 2016 Feb 18.

11.

EMRE is an essential component of the mitochondrial calcium uniporter complex.

Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK.

Science. 2013 Dec 13;342(6164):1379-82. doi: 10.1126/science.1242993. Epub 2013 Nov 14.

12.

Mitochondrial function and insulin secretion.

Maechler P.

Mol Cell Endocrinol. 2013 Oct 15;379(1-2):12-8. doi: 10.1016/j.mce.2013.06.019. Epub 2013 Jun 20. Review.

PMID:
23792187
13.

SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death.

Hoffman NE, Chandramoorthy HC, Shanmughapriya S, Zhang XQ, Vallem S, Doonan PJ, Malliankaraman K, Guo S, Rajan S, Elrod JW, Koch WJ, Cheung JY, Madesh M.

Mol Biol Cell. 2014 Mar;25(6):936-47. doi: 10.1091/mbc.E13-08-0502. Epub 2014 Jan 15.

14.

The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake.

Petrungaro C, Zimmermann KM, Küttner V, Fischer M, Dengjel J, Bogeski I, Riemer J.

Cell Metab. 2015 Oct 6;22(4):721-33. doi: 10.1016/j.cmet.2015.08.019. Epub 2015 Sep 17.

15.

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

Mallilankaraman K, Doonan P, Cárdenas C, Chandramoorthy HC, Müller M, Miller R, Hoffman NE, Gandhirajan RK, Molgó J, Birnbaum MJ, Rothberg BS, Mak DO, Foskett JK, Madesh M.

Cell. 2012 Oct 26;151(3):630-44. doi: 10.1016/j.cell.2012.10.011.

16.

EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter.

Vais H, Mallilankaraman K, Mak DO, Hoff H, Payne R, Tanis JE, Foskett JK.

Cell Rep. 2016 Jan 26;14(3):403-10. doi: 10.1016/j.celrep.2015.12.054. Epub 2016 Jan 7.

17.

Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake.

Wang L, Yang X, Li S, Wang Z, Liu Y, Feng J, Zhu Y, Shen Y.

EMBO J. 2014 Mar 18;33(6):594-604. doi: 10.1002/embj.201386523. Epub 2014 Feb 10.

18.

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.

Csordás G, Golenár T, Seifert EL, Kamer KJ, Sancak Y, Perocchi F, Moffat C, Weaver D, de la Fuente Perez S, Bogorad R, Koteliansky V, Adijanto J, Mootha VK, Hajnóczky G.

Cell Metab. 2013 Jun 4;17(6):976-87. doi: 10.1016/j.cmet.2013.04.020.

19.

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.

Kamer KJ, Mootha VK.

EMBO Rep. 2014 Mar;15(3):299-307. doi: 10.1002/embr.201337946. Epub 2014 Feb 6.

20.

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.

Logan CV, Szabadkai G, Sharpe JA, Parry DA, Torelli S, Childs AM, Kriek M, Phadke R, Johnson CA, Roberts NY, Bonthron DT, Pysden KA, Whyte T, Munteanu I, Foley AR, Wheway G, Szymanska K, Natarajan S, Abdelhamed ZA, Morgan JE, Roper H, Santen GW, Niks EH, van der Pol WL, Lindhout D, Raffaello A, De Stefani D, den Dunnen JT, Sun Y, Ginjaar I, Sewry CA, Hurles M, Rizzuto R; UK10K Consortium, Duchen MR, Muntoni F, Sheridan E.

Nat Genet. 2014 Feb;46(2):188-93. doi: 10.1038/ng.2851. Epub 2013 Dec 15.

PMID:
24336167

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