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Items: 1 to 20 of 75

1.

Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses.

Procaccini C, De Rosa V, Galgani M, Carbone F, Cassano S, Greco D, Qian K, Auvinen P, Calì G, Stallone G, Formisano L, La Cava A, Matarese G.

J Immunol. 2012 Sep 15;189(6):2941-53. doi: 10.4049/jimmunol.1200935. Epub 2012 Aug 17.

2.

Interplay between mTOR and STAT5 signaling modulates the balance between regulatory and effective T cells.

Shan J, Feng L, Sun G, Chen P, Zhou Y, Xia M, Li H, Li Y.

Immunobiology. 2015 Apr;220(4):510-7. doi: 10.1016/j.imbio.2014.10.020. Epub 2014 Oct 31.

PMID:
25468562
3.

An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness.

Procaccini C, De Rosa V, Galgani M, Abanni L, Calì G, Porcellini A, Carbone F, Fontana S, Horvath TL, La Cava A, Matarese G.

Immunity. 2010 Dec 14;33(6):929-41. doi: 10.1016/j.immuni.2010.11.024. Epub 2010 Dec 9.

4.

Campylobacter jejuni induces colitis through activation of mammalian target of rapamycin signaling.

Sun X, Threadgill D, Jobin C.

Gastroenterology. 2012 Jan;142(1):86-95.e5. doi: 10.1053/j.gastro.2011.09.042. Epub 2011 Oct 1.

5.

Rapamycin-sensitive signals control TCR/CD28-driven Ifng, Il4 and Foxp3 transcription and promoter region methylation.

Tomasoni R, Basso V, Pilipow K, Sitia G, Saccani S, Agresti A, Mietton F, Natoli G, Colombetti S, Mondino A.

Eur J Immunol. 2011 Jul;41(7):2086-96. doi: 10.1002/eji.201041130.

6.

Leptin modulates autophagy in human CD4+CD25- conventional T cells.

Cassano S, Pucino V, La Rocca C, Procaccini C, De Rosa V, Marone G, Matarese G.

Metabolism. 2014 Oct;63(10):1272-9. doi: 10.1016/j.metabol.2014.06.010. Epub 2014 Jun 19.

7.
8.

mTOR-dependent modulation of gastric nesfatin-1/NUCB2.

Li Z, Xu G, Li Y, Zhao J, Mulholland MW, Zhang W.

Cell Physiol Biochem. 2012;29(3-4):493-500. doi: 10.1159/000338503. Epub 2012 Apr 3.

9.

Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation.

Salmond RJ, Brownlie RJ, Meyuhas O, Zamoyska R.

J Immunol. 2015 Nov 15;195(10):4615-22. doi: 10.4049/jimmunol.1501473. Epub 2015 Oct 9.

10.

Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells.

Wang C, Yi T, Qin L, Maldonado RA, von Andrian UH, Kulkarni S, Tellides G, Pober JS.

J Clin Invest. 2013 Apr;123(4):1677-93. doi: 10.1172/JCI66204. Epub 2013 Mar 8.

11.

Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo.

Yurchenko E, Shio MT, Huang TC, Da Silva Martins M, Szyf M, Levings MK, Olivier M, Piccirillo CA.

PLoS One. 2012;7(4):e35572. doi: 10.1371/journal.pone.0035572. Epub 2012 Apr 24.

12.

Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway.

Galgani M, Procaccini C, De Rosa V, Carbone F, Chieffi P, La Cava A, Matarese G.

J Immunol. 2010 Dec 15;185(12):7474-9. doi: 10.4049/jimmunol.1001674. Epub 2010 Nov 15.

13.

Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle.

Eghtesad S, Jhunjhunwala S, Little SR, Clemens PR.

Mol Med. 2011 Sep-Oct;17(9-10):917-24. doi: 10.2119/molmed.2010.00256. Epub 2011 May 20.

14.

Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.

Efimova O, Szankasi P, Kelley TW.

PLoS One. 2011 Jan 6;6(1):e16013. doi: 10.1371/journal.pone.0016013.

15.

mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.

Ito D, Nojima S, Nishide M, Okuno T, Takamatsu H, Kang S, Kimura T, Yoshida Y, Morimoto K, Maeda Y, Hosokawa T, Toyofuku T, Ohshima J, Kamimura D, Yamamoto M, Murakami M, Morii E, Rakugi H, Isaka Y, Kumanogoh A.

J Immunol. 2015 Aug 1;195(3):934-43. doi: 10.4049/jimmunol.1403038. Epub 2015 Jun 26.

16.

Selective capacity of metreleptin administration to reconstitute CD4+ T-cell number in females with acquired hypoleptinemia.

Matarese G, La Rocca C, Moon HS, Huh JY, Brinkoetter MT, Chou S, Perna F, Greco D, Kilim HP, Gao C, Arampatzi K, Wang Z, Mantzoros CS.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E818-27. doi: 10.1073/pnas.1214554110. Epub 2013 Feb 4.

17.

Involvement of mTOR in CXCL12 mediated T cell signaling and migration.

Munk R, Ghosh P, Ghosh MC, Saito T, Xu M, Carter A, Indig F, Taub DD, Longo DL.

PLoS One. 2011;6(9):e24667. doi: 10.1371/journal.pone.0024667. Epub 2011 Sep 12.

18.

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells.

Haxhinasto S, Mathis D, Benoist C.

J Exp Med. 2008 Mar 17;205(3):565-74. doi: 10.1084/jem.20071477. Epub 2008 Feb 18.

19.

Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes.

Delgoffe GM, Powell JD.

Methods Mol Biol. 2012;821:317-27. doi: 10.1007/978-1-61779-430-8_20.

20.

Leucine promotes leptin receptor expression in mouse C2C12 myotubes through the mTOR pathway.

Mao X, Zeng X, Wang J, Qiao S.

Mol Biol Rep. 2011 Jun;38(5):3201-6. doi: 10.1007/s11033-010-9992-6. Epub 2010 Feb 12.

PMID:
20151325

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