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A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.

Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, Pandolfi PP.

Nat Med. 2012 Sep;18(9):1350-8.


A ROSy future for metabolic regulation of HSC division.

Broxmeyer HE, Mantel C.

Nat Med. 2012 Sep;18(9):1334-6. doi: 10.1038/nm.2917. No abstract available.


A metabolic prosurvival role for PML in breast cancer.

Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP.

J Clin Invest. 2012 Sep;122(9):3088-100. doi: 10.1172/JCI62129. Epub 2012 Aug 13.


The role of PML in hematopoietic and leukemic stem cell maintenance.

Nakahara F, Weiss CN, Ito K.

Int J Hematol. 2014 Jul;100(1):18-26. doi: 10.1007/s12185-014-1518-x. Epub 2014 Feb 1. Review.


Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes.

Robciuc MR, Skrobuk P, Anisimov A, Olkkonen VM, Alitalo K, Eckel RH, Koistinen HA, Jauhiainen M, Ehnholm C.

PLoS One. 2012;7(10):e46212. doi: 10.1371/journal.pone.0046212. Epub 2012 Oct 4.


Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy.

Cheng L, Ding G, Qin Q, Huang Y, Lewis W, He N, Evans RM, Schneider MD, Brako FA, Xiao Y, Chen YE, Yang Q.

Nat Med. 2004 Nov;10(11):1245-50. Epub 2004 Oct 10.


PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function.

Kleiner S, Nguyen-Tran V, Baré O, Huang X, Spiegelman B, Wu Z.

J Biol Chem. 2009 Jul 10;284(28):18624-33. doi: 10.1074/jbc.M109.008797. Epub 2009 May 12.


Peroxisome proliferator-activated receptor-delta agonist enhances vasculogenesis by regulating endothelial progenitor cells through genomic and nongenomic activations of the phosphatidylinositol 3-kinase/Akt pathway.

Han JK, Lee HS, Yang HM, Hur J, Jun SI, Kim JY, Cho CH, Koh GY, Peters JM, Park KW, Cho HJ, Lee HY, Kang HJ, Oh BH, Park YB, Kim HS.

Circulation. 2008 Sep 2;118(10):1021-33. doi: 10.1161/CIRCULATIONAHA.108.777169. Epub 2008 Aug 18.


Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells.

Coll T, Alvarez-Guardia D, Barroso E, Gómez-Foix AM, Palomer X, Laguna JC, Vázquez-Carrera M.

Endocrinology. 2010 Apr;151(4):1560-9. doi: 10.1210/en.2009-1211. Epub 2010 Feb 25.


mTORC1 signaling governs hematopoietic stem cell quiescence.

Gan B, DePinho RA.

Cell Cycle. 2009 Apr 1;8(7):1003-6. Epub 2009 Apr 2.


Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs.

Park SM, Deering RP, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert BL, Hacohen N, Leslie C, Daley GQ, Lengner CJ, Kharas MG.

J Exp Med. 2014 Jan 13;211(1):71-87. doi: 10.1084/jem.20130736. Epub 2014 Jan 6.


High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes.

Li Y, Cheng L, Qin Q, Liu J, Lo WK, Brako LA, Yang Q.

J Mol Cell Cardiol. 2009 Oct;47(4):536-43. doi: 10.1016/j.yjmcc.2009.07.001. Epub 2009 Jul 9.


AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.

Li Q, He Y, Wei L, Wu X, Wu D, Lin S, Wang Z, Ye Z, Lin SC.

Oncogene. 2011 Mar 10;30(10):1194-204. doi: 10.1038/onc.2010.499. Epub 2010 Nov 8.


The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.

Barroso E, Rodríguez-Calvo R, Serrano-Marco L, Astudillo AM, Balsinde J, Palomer X, Vázquez-Carrera M.

Endocrinology. 2011 May;152(5):1848-59. doi: 10.1210/en.2010-1468. Epub 2011 Mar 1.


[PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids].

Yan Y, Wang ZB, Tang CK.

Sheng Li Ke Xue Jin Zhan. 2016 Feb;47(1):1-6. Review. Chinese.


In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats.

Yue TL, Nerurkar SS, Bao W, Jucker BM, Sarov-Blat L, Steplewski K, Ohlstein EH, Willette RN.

J Pharmacol Exp Ther. 2008 May;325(2):466-74. doi: 10.1124/jpet.107.135327. Epub 2008 Feb 20.


Promyelocytic leukemia inhibits adipogenesis, and loss of promyelocytic leukemia results in fat accumulation in mice.

Kim MK, Yang S, Lee KH, Um JH, Liu M, Kang H, Park SJ, Chung JH.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1130-42. doi: 10.1152/ajpendo.00092.2011. Epub 2011 Aug 16.


Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.

Muoio DM, MacLean PS, Lang DB, Li S, Houmard JA, Way JM, Winegar DA, Corton JC, Dohm GL, Kraus WE.

J Biol Chem. 2002 Jul 19;277(29):26089-97. Epub 2002 May 6.


A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARalpha-/- mice possibly through PGC-1 mediated PPARdelta coactivation.

Røst TH, Haugan Moi LL, Berge K, Staels B, Mellgren G, Berge RK.

Biochim Biophys Acta. 2009 Nov;1791(11):1076-83. doi: 10.1016/j.bbalip.2009.06.005. Epub 2009 Jul 3.


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