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Cardiac-specific overexpression of catalase attenuates lipopolysaccharide-induced myocardial contractile dysfunction: role of autophagy.

Turdi S, Han X, Huff AF, Roe ND, Hu N, Gao F, Ren J.

Free Radic Biol Med. 2012 Sep 15;53(6):1327-38. doi: 10.1016/j.freeradbiomed.2012.07.084.


Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis.

Ceylan-Isik AF, Zhao P, Zhang B, Xiao X, Su G, Ren J.

J Mol Cell Cardiol. 2010 Feb;48(2):367-78. doi: 10.1016/j.yjmcc.2009.11.003.


Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stress.

Dong M, Hu N, Hua Y, Xu X, Kandadi MR, Guo R, Jiang S, Nair S, Hu D, Ren J.

Biochim Biophys Acta. 2013 Jun;1832(6):848-63. doi: 10.1016/j.bbadis.2013.02.023.


Oxidative activation of Ca(2+)/calmodulin-activated kinase II mediates ER stress-induced cardiac dysfunction and apoptosis.

Roe ND, Ren J.

Am J Physiol Heart Circ Physiol. 2013 Mar 15;304(6):H828-39. doi: 10.1152/ajpheart.00752.2012.


Cardiac-specific overexpression of catalase attenuates paraquat-induced myocardial geometric and contractile alteration: role of ER stress.

Ge W, Zhang Y, Han X, Ren J.

Free Radic Biol Med. 2010 Dec 15;49(12):2068-77. doi: 10.1016/j.freeradbiomed.2010.10.686. Erratum in: Free Radic Biol Med. 2011 Jan 1;50(1):217. Ge, We [corrected to Ge, Wei].


Ablation of Akt2 protects against lipopolysaccharide-induced cardiac dysfunction: role of Akt ubiquitination E3 ligase TRAF6.

Zhang Y, Xu X, Ceylan-Isik AF, Dong M, Pei Z, Li Y, Ren J.

J Mol Cell Cardiol. 2014 Sep;74:76-87. doi: 10.1016/j.yjmcc.2014.04.020.


[Cardiac metallothionein overexpression improves cardiac contractile function and attenuates oxidative stress in lipopolysaccharide-treated mice].

Zhao P, Zhang J, Chu X, Yuan HT, Cui LQ, Zhu XL.

Zhonghua Xin Xue Guan Bing Za Zhi. 2011 Aug;39(8):711-6. Chinese.


Antioxidant catalase rescues against high fat diet-induced cardiac dysfunction via an IKKβ-AMPK-dependent regulation of autophagy.

Liang L, Shou XL, Zhao HK, Ren GQ, Wang JB, Wang XH, Ai WT, Maris JR, Hueckstaedt LK, Ma AQ, Zhang Y.

Biochim Biophys Acta. 2015 Feb;1852(2):343-52. doi: 10.1016/j.bbadis.2014.06.027.


Cardiac-specific overexpression of metallothionein rescues against cigarette smoking exposure-induced myocardial contractile and mitochondrial damage.

Hu N, Han X, Lane EK, Gao F, Zhang Y, Ren J.

PLoS One. 2013;8(2):e57151. doi: 10.1371/journal.pone.0057151.


Distinct effects of Nampt inhibition on mild and severe models of lipopolysaccharide-induced myocardial impairment.

Liu L, Wang P, Liang C, He D, Yu Y, Liu X.

Int Immunopharmacol. 2013 Oct;17(2):342-9. doi: 10.1016/j.intimp.2013.06.017.


Heavy metal scavenger metallothionein attenuates ER stress-induced myocardial contractile anomalies: role of autophagy.

Yang L, Hu N, Jiang S, Zou Y, Yang J, Xiong L, Ren J.

Toxicol Lett. 2014 Mar 21;225(3):333-41. doi: 10.1016/j.toxlet.2013.12.024.


Rac1 mediates sex difference in cardiac tumor necrosis factor-alpha expression via NADPH oxidase-ERK1/2/p38 MAPK pathway in endotoxemia.

Zhu H, Shan L, Peng T.

J Mol Cell Cardiol. 2009 Aug;47(2):264-74. doi: 10.1016/j.yjmcc.2009.05.002.


Cardiac-specific overexpression of metallothionein attenuates myocardial remodeling and contractile dysfunction in l-NAME-induced experimental hypertension: Role of autophagy regulation.

Yang L, Gao JY, Ma J, Xu X, Wang Q, Xiong L, Yang J, Ren J.

Toxicol Lett. 2015 Sep 2;237(2):121-32. doi: 10.1016/j.toxlet.2015.06.005.


LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection.

Yuan H, Perry CN, Huang C, Iwai-Kanai E, Carreira RS, Glembotski CC, Gottlieb RA.

Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H470-9. doi: 10.1152/ajpheart.01051.2008.

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