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Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system.

Otsubo Y, Satoh Y, Kodama M, Araki Y, Satomoto M, Sakamoto E, Pagès G, Pouysségur J, Endo S, Kazama T.

Pain. 2012 Nov;153(11):2241-52. doi: 10.1016/j.pain.2012.07.020.


Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models.

Alter BJ, Zhao C, Karim F, Landreth GE, Gereau RW 4th.

J Neurosci. 2010 Aug 25;30(34):11537-47. doi: 10.1523/JNEUROSCI.6103-09.2010.


ERK2 contributes to the control of social behaviors in mice.

Satoh Y, Endo S, Nakata T, Kobayashi Y, Yamada K, Ikeda T, Takeuchi A, Hiramoto T, Watanabe Y, Kazama T.

J Neurosci. 2011 Aug 17;31(33):11953-67. doi: 10.1523/JNEUROSCI.2349-11.2011.


ERK2 Alone Drives Inflammatory Pain But Cooperates with ERK1 in Sensory Neuron Survival.

O'Brien DE, Alter BJ, Satomoto M, Morgan CD, Davidson S, Vogt SK, Norman ME, Gereau GB, Demaro JA 3rd, Landreth GE, Golden JP, Gereau RW 4th.

J Neurosci. 2015 Jun 24;35(25):9491-507. doi: 10.1523/JNEUROSCI.4404-14.2015.


Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freund's adjuvant-induced pain hypersensitivity.

Xu Q, Garraway SM, Weyerbacher AR, Shin SJ, Inturrisi CE.

J Neurosci. 2008 Dec 24;28(52):14087-96. doi: 10.1523/JNEUROSCI.2406-08.2008.


Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation.

Voisin L, Saba-El-Leil MK, Julien C, Frémin C, Meloche S.

Mol Cell Biol. 2010 Jun;30(12):2918-32. doi: 10.1128/MCB.00131-10.


Region- or state-related differences in expression and activation of extracellular signal-regulated kinases (ERKs) in naïve and pain-experiencing rats.

Guo SW, Liu MG, Long YL, Ren LY, Lu ZM, Yu HY, Hou JF, Li H, Gao CY, Cui XY, An YY, Li J, Zhao LF, Chen J.

BMC Neurosci. 2007 Jul 24;8:53.


Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice.

Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S.

Anesth Analg. 2009 Oct;109(4):1305-11. doi: 10.1213/ane.0b013e3181b1dca2.


Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain.

Saha M, Skopelja S, Martinez E, Alvarez DL, Liponis BS, Romero-Sandoval EA.

J Neurosci. 2013 Oct 23;33(43):17182-7. doi: 10.1523/JNEUROSCI.5605-12.2013.


Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.

Obata K, Yamanaka H, Kobayashi K, Dai Y, Mizushima T, Katsura H, Fukuoka T, Tokunaga A, Noguchi K.

J Neurosci. 2004 Nov 10;24(45):10211-22.


Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor.

Hung VK, Tai LW, Qiu Q, Luo X, Wong KL, Chung SK, Cheung CW.

Mol Cell Neurosci. 2014 May;60:26-35. doi: 10.1016/j.mcn.2014.02.007.


ERK1/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination.

Ishii A, Fyffe-Maricich SL, Furusho M, Miller RH, Bansal R.

J Neurosci. 2012 Jun 27;32(26):8855-64. doi: 10.1523/JNEUROSCI.0137-12.2012.


Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice.

Staniland AA, Clark AK, Wodarski R, Sasso O, Maione F, D'Acquisto F, Malcangio M.

J Neurochem. 2010 Aug;114(4):1143-57. doi: 10.1111/j.1471-4159.2010.06837.x.


Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory.

Satoh Y, Endo S, Ikeda T, Yamada K, Ito M, Kuroki M, Hiramoto T, Imamura O, Kobayashi Y, Watanabe Y, Itohara S, Takishima K.

J Neurosci. 2007 Oct 3;27(40):10765-76.


Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice.

Hasue F, Kuwaki T, Kisanuki YY, Yanagisawa M, Moriya H, Fukuda Y, Shimoyama M.

Neuroscience. 2005;130(2):349-58.


Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2.

Frémin C, Bessard A, Ezan F, Gailhouste L, Régeard M, Le Seyec J, Gilot D, Pagès G, Pouysségur J, Langouët S, Baffet G.

Hepatology. 2009 Mar;49(3):930-9. doi: 10.1002/hep.22730.


Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation.

Yao Y, Li W, Wu J, Germann UA, Su MS, Kuida K, Boucher DM.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12759-64.


Extracellular signaling-regulated kinase-1 and -2 (ERK 1/2) mediate referred hyperalgesia in a murine model of visceral pain.

Galan A, Cervero F, Laird JM.

Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):126-34.


The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition.

Meloche S, Pouysségur J.

Oncogene. 2007 May 14;26(22):3227-39. Review.


Selective prevention of mechanical hyperalgesia after incision by spinal ERK1/2 inhibition.

van den Heuvel I, Reichl S, Segelcke D, Zahn PK, Pogatzki-Zahn EM.

Eur J Pain. 2015 Feb;19(2):225-35. doi: 10.1002/ejp.540.

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