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Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain.

Landry RP, Martinez E, DeLeo JA, Romero-Sandoval EA.

J Pain. 2012 Sep;13(9):836-48. doi: 10.1016/j.jpain.2012.05.013. Epub 2012 Aug 14.


Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury.

Romero-Sandoval A, Nutile-McMenemy N, DeLeo JA.

Anesthesiology. 2008 Apr;108(4):722-34. doi: 10.1097/ALN.0b013e318167af74.


Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain.

Saha M, Skopelja S, Martinez E, Alvarez DL, Liponis BS, Romero-Sandoval EA.

J Neurosci. 2013 Oct 23;33(43):17182-7. doi: 10.1523/JNEUROSCI.5605-12.2013.


Intrathecal injection of JWH015 attenuates remifentanil-induced postoperative hyperalgesia by inhibiting activation of spinal glia in a rat model.

Sun Y, Zhang W, Liu Y, Liu X, Ma Z, Gu X.

Anesth Analg. 2014 Apr;118(4):841-53. doi: 10.1213/ANE.0000000000000146.


Triptolide prevents and attenuates neuropathic pain via inhibiting central immune response.

Wang W, Mei XP, Chen L, Tang J, Li JL, Wu SX, Xu LX, Li YQ.

Pain Physician. 2012 Nov-Dec;15(6):E995-1006.


Intrathecal administration of the cannabinoid 2 receptor agonist JWH015 can attenuate cancer pain and decrease mRNA expression of the 2B subunit of N-methyl-D-aspartic acid.

Gu X, Mei F, Liu Y, Zhang R, Zhang J, Ma Z.

Anesth Analg. 2011 Aug;113(2):405-11. doi: 10.1213/ANE.0b013e31821d1062. Epub 2011 Apr 25.


Clonidine, an alpha-2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin-induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension.

Yeo JH, Yoon SY, Kim SJ, Oh SB, Lee JH, Beitz AJ, Roh DH.

Int J Cancer. 2016 May 15;138(10):2466-76. doi: 10.1002/ijc.29980. Epub 2016 Jan 11.


Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury.

Brownjohn PW, Ashton JC.

Neuroscience. 2012 Feb 17;203:180-93. doi: 10.1016/j.neuroscience.2011.12.028. Epub 2011 Dec 22.


RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain.

Tatsumi E, Yamanaka H, Kobayashi K, Yagi H, Sakagami M, Noguchi K.

Glia. 2015 Feb;63(2):216-28. doi: 10.1002/glia.22745. Epub 2014 Aug 14.


Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression.

Fan H, Li TF, Gong N, Wang YX.

Neuropharmacology. 2016 Feb;101:98-109. doi: 10.1016/j.neuropharm.2015.09.010. Epub 2015 Sep 9.


Ketamine depresses toll-like receptor 3 signaling in spinal microglia in a rat model of neuropathic pain.

Mei XP, Zhou Y, Wang W, Tang J, Wang W, Zhang H, Xu LX, Li YQ.

Neurosignals. 2011;19(1):44-53. doi: 10.1159/000324293. Epub 2011 Mar 9.


Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery.

Rahn EJ, Deng L, Thakur GA, Vemuri K, Zvonok AM, Lai YY, Makriyannis A, Hohmann AG.

Mol Pain. 2014 Apr 18;10:27. doi: 10.1186/1744-8069-10-27.


CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection.

Srivastava N, Sudan R, Saha B.

J Immunol. 2011 May 15;186(10):5863-72. doi: 10.4049/jimmunol.1003957. Epub 2011 Apr 6.


Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.

Obata K, Yamanaka H, Kobayashi K, Dai Y, Mizushima T, Katsura H, Fukuoka T, Tokunaga A, Noguchi K.

J Neurosci. 2004 Nov 10;24(45):10211-22.


Sigma-1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of mechanical allodynia in mice and neuropathic rats.

Moon JY, Roh DH, Yoon SY, Kang SY, Choi SR, Kwon SG, Choi HS, Han HJ, Beitz AJ, Lee JH.

Exp Neurol. 2013 Sep;247:383-91. doi: 10.1016/j.expneurol.2013.01.004. Epub 2013 Jan 15.


Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain.

Alkaitis MS, Solorzano C, Landry RP, Piomelli D, DeLeo JA, Romero-Sandoval EA.

PLoS One. 2010 May 28;5(5):e10891. doi: 10.1371/journal.pone.0010891.

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